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Advanced Biomolecular NMR and Structural Biology

University of Patras

Dr. Spyroulias is a leading expert in biomolecular NMR and structural biology, with extensive experience in the solution structure, dynamics, and interaction of biomolecules using advanced NMR and computational modeling techniques. His research focuses on protein engineering, biophysical characterization, and NMR-driven drug discovery, including virtual screening, pharmacophore modeling, and lead optimization for novel therapeutics. Dr. Spyroulias is also recognized for his work in NMR-based metabolomics, enabling metabolite profiling and biomarker discovery in biological fluids. He has directed structured training programs and mentored fellows in advanced NMR methodologies, protein expression, purification, and biophysical analysis, and has contributed significantly to research and innovation in structural biology and drug design.

Main Areas of Interest

Biomolecular NMR and Structural Biology: Solution structure, dynamics, and interaction of biomolecules using advanced NMR and modeling techniques.
Protein Engineering and Biophysical Characterization: Recombinant protein expression, purification, labeling, and biophysical analysis with CD, SEC-MALS, MST, and ITC.
NMR-Driven Drug Discovery and Design: Virtual screening, pharmacophore modeling, and lead optimization for drug candidates.
NMR-Based Metabolomics: Metabolite profiling and fingerprinting in biological fluids using NMR.

Specialties

Biochemistry

Techniques You Will Learn

Biomolecular NMR and Structural Analysis: Protein expression, purification, labeling, and advanced NMR for structure and interaction studies.
Protein Engineering and Biophysical Characterization: Training in recombinant protein production, isotope labeling, CD, SEC-MALS, MST, and ITC.
Molecular Modeling and Drug Design: Molecular dynamics, docking, virtual screening, and lead optimization.
NMR-Based Metabolomics: Practical skills in NMR metabolomics for biomarker discovery and metabolic analysis.
Advanced Instrumentation and Data Analysis: Operation of NMR and CD spectrometers, and computational data analysis platforms.

Curriculum

Foundations in Biomolecular NMR and Structural Biology
Orientation to laboratory workflow, safety, and experimental planning.
Introduction to protein expression, purification, and labeling for NMR studies.
Hands-on training in basic NMR data acquisition and spectral analysis.
Overview of molecular modeling and docking simulations.
Advanced Biophysical Characterization
Training in circular dichroism (CD) for protein conformation and stability.
Practical sessions with SEC-MALS for protein oligomerization analysis.
Introduction to microscale thermophoresis (MST) and isothermal titration calorimetry (ITC).
Case discussions on interpreting biophysical data and interaction thermodynamics.
NMR-Driven Drug Discovery
Hands-on virtual screening and pharmacophore modeling.
Docking simulations and lead optimization using computational platforms.
Analysis of protein-ligand and protein-protein interaction data.
Participation in research meetings and journal clubs.
NMR-Based Metabolomics and Multidisciplinary Integration
Introduction to NMR metabolomics: metabolic profiling and fingerprinting.
Data processing and interpretation of metabolomics experiments.
Participation in multidisciplinary research discussions and final feedback session.
Certification of completion and review of learning outcomes.

Accommodation

Try airbnb.com

Fees and Program Logistics

This program has the following durations available:

Duration	Fee
2 weeks	$1,063.00
6 weeks	$1,594.00
8 weeks	$2,750.00

Who Can Apply

Biochemistry professionals

Host Details

Host Name: Georgios A.Spyroulias

Affiliation: University of Patras

Address: University of Patras, Department of Pharmacy, Patras, GREECE.

Website URL:

Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.

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