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Research Grant Awards

St. Baldrick's Foundation

These grants are for specific two-year research projects which are hypothesis driven and may be either laboratory, clinical, or epidemiological in nature. Please submit a realistic budget for the project. Grants will be $100,000/year or less, for two years.

esearch Grants are one of many funding categories offered by the St. Baldrick’s Foundation; it is possible for a program/institution to receive funding in more than one category. With the exception noted immediately below, each program/institution may submit one (1) LOI/application in all open St. Baldrick’s funding categories.

AI Based Application Success Predictor

1. Clear, Direct Focus on Childhood Cancer

The top predictor is that the project specifically benefits pediatric/AYA cancer patients, including:

Leukemias (ALL, AML)

Brain & CNS tumors (medulloblastoma, glioma, DIPG/DMG)

Neuroblastoma

Sarcomas (osteosarcoma, Ewing, RMS)

Lymphoma

Rare pediatric malignancies (histiocytic disorders, germ cell tumors)

High-priority themes:

Relapsed/refractory disease

Drug resistance mechanisms

Targeted and immunotherapies

Minimal residual disease detection

Novel biomarkers

Treatment toxicity reduction & survivorship

Neurocognitive, endocrine, psychosocial outcomes

❗ Adult oncology projects with children as a subpopulation do not score well.

2. Mechanism Alignment With Career Stage & Project Scope

Perfect match matters:

Mechanism	Best For	Critical Criteria
St. Baldrick’s Fellows	Pediatric oncology trainees	Mentorship + training environment
Early Career / Scholar Awards	Junior faculty	Trajectory → independent funding
Translational/Consortium	Established investigators & multi-site teams	Patient access + clinical impact
Supportive Care Grants	Clinicians & outcomes researchers	QoL, toxicity mitigation, disparities

Predictor: Fit PI career stage, project maturity, and patient access to the exact call.

3. Strong Preliminary Data

Even pilot grants show:

Feasibility proven in models or early trials

Early biomarker signals

Evidence that required assays, recruitment, and collaborations are established

Target expression or mechanistic rationale validated in pediatric tumors

Predictor: Feasibility and strong rationale → major scoring factor.

4. Pediatric-Relevant Models and Patient Access

Winning proposals leverage:

Patient-derived xenografts (PDX) from children

Pediatric tumor cell lines or organoids

Multi-omics data from pediatric tumors

Access to biobanks, Children’s Oncology Group (COG), pediatric trial groups

Defined cohort recruitment strategy for clinical studies

Predictor: Authentic pediatric relevance is essential.

5. Translational or Clinical Trial Pathway

St. Baldrick’s wants to change outcomes, not only understand disease.

Funded proposals show:

Clear route to trials within 3–5 years

IND-enabling milestones if drug-focused

Biomarker validation toward clinical utility

Defined endpoints to prove patient benefit

Predictor: Promising pathway to clinical impact increases enthusiasm.

6. Strong Investigator Track Record

Reviewers reward:

Publications in pediatric oncology

Prior success in grant delivery

Unique expertise aligned to the project

Clear development into a leader in childhood cancer research

Predictor: PI quality is heavily weighted, especially for Scholar/Faculty awards.

7. Excellence in Mentorship & Environment (for Trainees/Early-Career)

Critical criteria:

Well-funded primary mentor with pediatric oncology leadership

Protected time for research

Robust institutional infrastructure (cores, patients, imaging, GMP if needed)

Co-mentors for complementary skillsets

Predictor: Mentor strength influences reviewer confidence.

8. Well-Defined, Milestone-Based Aims

Best proposals include:

2–3 hypothesis-driven aims

Rapid, measurable milestones

Clear go/no-go decisions

Realistic for 1–3 year timelines

Plan for future funding (NIH/DOD/COG)

Predictor: Feasibility & clarity are top scoring criteria.

9. High Innovation & Urgency

St. Baldrick’s seeks transformative solutions:

First-in-field mechanistic insights

Novel cell/gene therapies

Combination regimens addressing resistance

Real-world solutions to survivorship harms

Cross-disciplinary technologies

Predictor: Innovation + urgent clinical need = reviewer enthusiasm.

10. Clear, Convincing Writing

Winning proposals are:

Logically structured

Supported by visual preliminary data

Strong in rigor & methodology

Accessible to both clinicians and laboratory reviewers

Compliant with guidelines & page limits

Predictor: Clean writing often separates top-tier applications.

🏆 Summary — St. Baldrick’s Foundation Success Predictors

Predictor	Why It Matters
Pediatric cancer focus	Core mission
Mechanism alignment	Correct evaluation
Preliminary data	Feasibility validation
Pediatric models	Clinical relevance
Translational path	Near-term patient benefit
PI trajectory	Investment return
Mentorship & environment	Execution & independence
Feasible aims	Deliverable results
Innovation	Big impact potential
Strong writing	Higher reviewer scoring

Specialties

Cancer

Clinical Trials

Eligibility Requirements

ATTENTION: limited submissions policy exception: Due to high interest from donors and low numbers of past applications, one additional LOI/application will be accepted only if it focuses on one of the areas listed below. This allowance applies to the overall cycle—not to each program or funding category individually.

▪ Brain tumors – all types, including rare forms, especially atypical teratoid/rhabdoid tumor (AT/RT), diffuse intrinsic pontine glioma (DIPG)/diffuse midline glioma (DMG), and glioblastoma (GBM)

▪ Burkitt lymphoma – all types, especially sporadic

▪ Rhabdoid tumors - Extrarenal

• During each grant cycle, an applicant can only apply once as the lead Principal Investigator. This restriction applies also to the above described limited submissions policy exception.

• Co-Investigators/Co-Principal Investigators are allowed on Research Grants. The LOI/application is required to be submitted under one lead Principal Investigator.

• Institutions must be located in the United States.

• Applicants need not be American citizens; however, they must work at an academic, medical, or research institution within the United States.

• A program/institution is defined as an entity essentially operating under one management. o Any questions or questionable situations will be reviewed by a subset of the Scientific Advisory Board of St. Baldrick’s. Questions can be emailed to Grants@StBaldricks.org, please include a copy of the applicant’s biosketch.

• Institutions that are actively involved in (sponsor, promote, or participate in) non-St. Baldrick’s head-shaving fundraising events are not eligible to apply for St. Baldrick’s funding.

o St. Baldrick’s understands that hospitals and their fundraising agents and organizations cannot control what their many volunteers do. Some may undertake head-shaving fundraisers that hospital/agent/organization is not aware of and does not sanction or promote. These activities would not prevent the hospital’s researchers from applying for St. Baldrick’s grants.

o The following applies to hospitals, their fundraising agents and organizations as institutions. Researchers from hospitals would be ineligible to apply for St. Baldrick’s grants if the hospital/agent/ organization promotes (advertises, emails, blogs, media stories, social media posts, shares, reshares, likes, tweets, re-tweets or hosts web pages) a non-St. Baldrick’s head-shaving fundraiser through any type of marketing, advertising, outreach or public-facing collateral or ancillary materials, or on any channel (television, radio, print, social media, website, etc.), using any content that sponsors, highlights, advocates or recommends a head-shaving event other than St. Baldrick’s.

• St. Baldrick’s funds may not be used for human embryonic stem cell research.

• Research projects must have direct applicability and relevance to pediatric cancer. They may be in any discipline of basic, clinical, translational, or epidemiological research.

• Research Grant applicants should hold at least an M.D./D.O. or Ph.D. degree by the date the award becomes effective.

• Applicants must be employed by an academic or non-profit research institution or laboratory.

• All qualified applicants will receive consideration for funding without regard to race, color, ethnicity/national origin, sex, sexual orientation, gender identity or expression, pregnancy, religion, belief and spirituality, age disability status, protected veteran status, or any other characteristic protected by law.

Sponsor Details

Sponsor Institute/Organizations: St. Baldrick's Foundation

Sponsor Type: Corporate/Non-Profit

Address: 1333 South Mayflower Avenue, Suite 400 Monrovia, CA 91016

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