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Physician Scientist Fellow Award

The Leukemia & Lymphoma Society of Canada

Canadian early-career blood cancer researchers are invited to submit proposals to The Leukemia & Lymphoma Society of Canada (LLSC)'s Physician Scientist Fellow Award Program Competition. This is a two-year grant designed to provide funding to early-stage specialist clinicians. This award will provide funding for salary only for up to $85,000 per year for two years.

This Fellow Award is specifically targeted at MDs near, or recently at, the completion of specialty training in hematology, oncology, hematopathology, pathology, or other related disciplines and who have initiated or have immediate plans to begin supervised research training directed at blood cancers. This opportunity is designed to foster, through provision of a contribution to their salary, the acquisition of skills and independence to conduct research in blood cancers at the laboratory, clinical or combined levels.

Key dates for 2025-2026

Call for Proposals - October 30, 2025
Letter of Intent (LOI) deadline - December 4, 2025, 4 pm ET
Notification of Full Application invite - December 2025
Full Application deadline - February 18, 2026, 4 pm ET
Review Panel meeting - May 2026
Notification of Awards - Fall 2026
Award start date - November 2026

AI Based Application Success Predictor

1. Direct Relevance to Blood Cancers

The strongest predictor is focusing specifically on hematologic malignancies:

Leukemias (ALL, AML, CLL, CML)

Lymphomas (Hodgkin & Non-Hodgkin)

Myeloma & Waldenström’s macroglobulinemia

MDS, MPNs & other marrow failure states

Pediatric and AYA cancers (high priority)

High-value themes:

Drug resistance & relapse prevention

MRD and early detection biomarkers

Immunotherapy (CAR-T, BiTEs, NK, vaccines)

Targeted therapies (BCL2, FLT3, IDH1/2, BTK inhibitors)

Genomic & epigenetic vulnerabilities

High-risk or underserved populations

Survivorship toxicities and late effects

❗ Generic oncology proposals without a hematologic cancer focus are not competitive.

2. Strong Alignment With the Mechanism

Each mechanism has distinct expectations:

Mechanism	Ideal Applicant	What Reviewers Look For
Early-Career & Fellowship Awards	New investigators	Mentorship + trajectory + institutional support
Translational & Clinical Grants	Mid-career and clinician-scientists	Path to clinical adoption + patient access
Pediatric & Survivorship Grants	Teams with pediatric patient networks	Impact on cure rates, late effects, QoL

Predictor: Match career stage, project maturity, and disease focus to the program.

3. Canadian Patient Impact

LLSC is very Canada-focused. Competitive proposals show:

Direct benefit for Canadian patients

Use of national datasets, biobanks, or BMT networks

Cross-province collaboration and site access

Patient partner involvement and knowledge translation plans

Predictor: Clearly state why this matters to Canadians with blood cancers.

4. Feasible, Translational Pathway

LLSC prioritizes near-term clinical relevance, including:

IND- or trial-ready therapeutics

Biomarkers aligned to treatment decisions

Real-world health system research

Approaches that reduce treatment burden and late toxicity

Predictor: The proposal must articulate how results change patient care.

5. Strong Preliminary Data

Even exploratory grants typically benefit from:

Proof-of-concept experiments

Early clinical feasibility or pilot signals

Validated assays or analytic pipelines

Demonstrated access to required data or samples

Predictor: Preliminary evidence is one of the biggest success drivers.

6. Use of Relevant Human Models / Data

Highly scoring proposals employ:

Primary patient samples

Blood cancer cell lines and PDX models

BMT cohorts or immunotherapy datasets

Clinical MRD testing and multi-omics profiles

Predictor: Human relevance strengthens rigor and impact.

7. Strong Investigator Track Record

For faculty-level grants, reviewers emphasize:

Publications in hematologic malignancies

Demonstrated independence and scientific direction

Successful delivery of prior projects

Leadership in collaborative research

Predictor: A trajectory toward national or global leadership in hematologic oncology.

8. Multidisciplinary Collaboration

Partnerships are viewed very positively:

Clinician–scientist + immunology/bioinformatics combinations

Pediatric oncology networks

Multi-site clinical projects across Canada

Data-science or imaging experts

Predictor: Collaboration amplifies feasibility and generalizability.

9. Clear, Focused Aims & Milestones

LLSC grants are milestone-driven. Competitive proposals show:

2–3 sharply defined aims

Quantifiable outcomes

Strong stats plan and risk-mitigation

Logical path to future funding (Canadian or international)

Predictor: Tight scope = high feasibility score.

10. Strong Writing & Compliance

Winning applications are:

Concise, visually supported, and logically structured

Explicit about impacts on survival and quality of life

Fully compliant with format, eligibility, and budgeting guidelines

Predictor: Clear communication improves scientific and significance scoring.

🏆 Summary — LLSC Success Predictors

Predictor	Why It Matters
Blood cancer specificity	Core mission
Mechanism alignment	Proper reviewer expectations
Canadian patient impact	Major priority
Translational feasibility	Drives clinical benefit
Preliminary data	Demonstrates feasibility
Human samples / cohorts	Stronger relevance
Investigator track record	Execution confidence
Collaboration	Broadens impact
Focused aims	Within scope & timeline
Excellent writing	Higher reviewer enthusiasm

Specialties

Cancer

Eligibility Requirements

Definition of Principal Investigator (PI) Applicants to the Physician Scientist Fellow Award Program must meet the following criteria to be eligible for funding:

• Hold a MD.

• Applicants must have completed or be in their last year of their fellowship in hematology, oncology, hematopathology, pathology, or other related disciplines. Applicants are welcome to contact LLSC (paul.oconnell@lls.org) to determine their eligibility to apply.

• Applicants must be enrolled in either a Master’s or PhD program, or as a post-doctoral fellow at the time of application.

• Must propose research directly relevant to blood cancer.

• Research may be performed in the same laboratory as where their graduate degree research was performed, if applicable (e.g. Master’s,PhD).

• The maximum award per year is $85,000 for salary only. The final value of the Award may be limited by the applicant’s Sponsoring Institution’s salary range.

• It is anticipated that the proposed research will occupy a majority of the applicant’s research time. However, there are no requirements for a certain percent effort in our budget template.

• Must have a Sponsor ( see below for details).

• Must have a Sponsor with adequate funding that supports the research proposed. As it is required that the applicant’s Sponsor have current grants to fund the proposed research (Physician Scientist Fellow Awards will provide salary support), it is expected that there will be some overlap with current research support. Applications that include writing and figures directly from a Sponsor’s prior work will be unfavorably reviewed, with the exception of figures in the Background section of the application.

• Must be on a clear trajectory to an independent career in hematology/oncology with a focus on blood cancer and clinical translation. Applicants with little or no prior blood cancer experience will be considered provided there is clear evidence of a path forward in a career in blood cancer. The Sponsor (or Sponsor/co-Sponsor pair) must be appropriate for this career path.

• Must demonstrate the need for continued funding.

Sponsor Details

Sponsor Institute/Organizations: The Leukemia & Lymphoma Society of Canada

Sponsor Type: Corporate/Non-Profit

Address: 2 Lansing Square, Suite 601 Toronto, ON M2J 4P8

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