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Ovarian Cancer Research Program Clinical Trial Award

U.S Department of Defense

Summary: The OCRP Clinical Trial Award supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of ovarian cancer.

Distinctive Features: Clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance and/or emerging approaches and technologies. Proposed projects may range from small proof-of-concept trials (e.g., pilot, first-in-human, phase 0) to demonstrate the feasibility or inform the design of more advanced trials through large-scale trials to determine efficacy in relevant patient populations.

Funding Details: The Congressionally Directed Medical Research Programs (CDMRP) expects to allot roughly $5.6M to fund approximately two Clinical Trial Award applications with total cost caps of $2.8M per award. The maximum period of performance is 4 years. It is anticipated that awards made from this fiscal year 2026 (FY26) funding opportunity will be funded with FY26 funds, which will expire for use on September 30, 2032. Awards supported with FY26 funds will be made no later than September 30, 2027.

AI Based Application Success Predictor

1. Alignment with the specific Program Announcement (PA) (Highest Predictor ⭐⭐⭐⭐⭐)

This is consistently the most important predictor.

Every CDMRP mechanism has unique:

Research priorities
Funding intent
Award level
Eligibility
Innovation expectations
Translational expectations

Successful applicants carefully tailor their proposal to the exact mechanism, not merely the disease area.

Applications that fail to address the mechanism's stated objectives are frequently eliminated regardless of scientific quality.

2. Impact (Highest Predictor ⭐⭐⭐⭐⭐)

Unlike many agencies where scientific excellence dominates, CDMRP places exceptional emphasis on potential impact.

Reviewers ask:

Will this improve patient outcomes?
Will it solve an important clinical problem?
Will it transform current practice?
Will patients benefit?

Impact is frequently weighted as heavily as scientific merit.

Projects with only incremental advances rarely score well.

3. Innovation (Highest Predictor ⭐⭐⭐⭐⭐)

Innovation is one of the defining characteristics of CDMRP.

Highly competitive proposals usually include:

Novel biological concepts
First-in-field technologies
High-risk/high-reward science
AI applications
Precision medicine
Regenerative medicine
Cell therapy
Gene therapy
Novel biomarkers
New therapeutic platforms

Incremental projects are less competitive unless they provide exceptional impact.

4. Scientific Merit (Very High Predictor ⭐⭐⭐⭐⭐)

Reviewers carefully evaluate:

Scientific rationale
Importance of hypothesis
Experimental design
Statistical methods
Preliminary rationale (when appropriate)
Technical rigor

Weak methodology can prevent funding even for highly innovative ideas.

5. Translational Potential (Very High Predictor ⭐⭐⭐⭐⭐)

CDMRP strongly favors research that can move discoveries toward patient care.

Highly competitive proposals include a clear pathway toward:

Diagnostics
Medical devices
Drug development
Biomarkers
Clinical trials
Precision medicine
Clinical implementation

Applications should explain how the research will ultimately improve healthcare.

6. Consumer/Patient Relevance (Very High & Distinctive Predictor ⭐⭐⭐⭐⭐)

This is one of CDMRP's most distinctive features.

Many review panels include:

Patients
Survivors
Caregivers
Consumer advocates

Strong proposals demonstrate:

Patient-centered outcomes
Consumer engagement
Relevance to unmet patient needs
Meaningful improvements in quality of life

Consumer reviewers participate directly in many CDMRP peer-review panels.

7. Military and Veteran Relevance (when applicable) (Very High Predictor ⭐⭐⭐⭐☆)

Although many CDMRP programs serve the general population, reviewers often consider relevance to:

Active-duty personnel
Veterans
Military families
Military readiness
Combat-related conditions

For some programs (e.g., traumatic brain injury, orthopedic trauma, rehabilitation), this relevance is particularly important.

8. Strong Multidisciplinary Team (High Predictor ⭐⭐⭐⭐☆)

Successful applications often include:

Clinicians
Basic scientists
Engineers
Statisticians
Bioinformaticians
Industry collaborators
Patient advocates

Large Team Science awards especially require complementary expertise and integrated collaboration.

9. Feasibility and Project Management (High Predictor ⭐⭐⭐⭐☆)

Competitive applications demonstrate:

Realistic milestones
Risk mitigation
Timeline
Budget justification
Available infrastructure
Institutional resources

Even ambitious projects need credible execution plans.

10. Investigator and Institutional Strength (High Predictor ⭐⭐⭐⭐☆)

Reviewers assess:

Publication record
Previous grant success
Leadership
Relevant expertise
Institutional resources
Available facilities

For Career Development Awards, leadership potential and mentorship are additional strengths.

11. Programmatic Portfolio Fit (Unique CDMRP Predictor ⭐⭐⭐⭐☆)

Unlike NIH, CDMRP conducts a Programmatic Review after peer review.

Programmatic reviewers consider:

Balance across disease areas
Balance across research topics
Funding mechanism priorities
Military needs
Consumer priorities
Existing funded portfolio

A proposal with an excellent scientific score may still not be funded if it duplicates already-funded work or does not fit the current portfolio.

Specialties

Cancer

Oncology

Gynecology

Eligibility Requirements

Organization Extramural and intramural U.S. Department of War (DOW) organizations are eligible to apply, including foreign and domestic organizations, for-profit and nonprofit organizations, and public or private entities.

Principal Investigator Individuals affiliated with an eligible organization are eligible to be named as Principal Investigator (PI) on the application, regardless of ethnicity, nationality or citizenship status. Independent investigators at all academic levels (or equivalent) are eligible to be named as a PI on an application.

Cost Sharing Cost sharing is not an eligibility requirement.

Sponsor Details

Sponsor Institute/Organizations: U.S Department of Defense

Sponsor Type: Corporate/Non-Profit

Address: The Pentagon, Washington, DC 20301

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