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AAMDSIF Research Grants Program

Aplastic Anemia and MDS International Foundation

In 2026, AAMDSIF will accept proposals addressing these bone marrow failure disorders:

Aplastic Anemia, Myelodysplastic Syndromes/Neoplasms (MDS), or Paroxysmal Nocturnal Hemoglobinuria (PNH)

Funding is available to support two projects focusing on either Aplastic Anemia, MDS, or PNH at $80,000 over two years ($40,000 per year) judged to have the highest scientific merit by the AAMDSIF Medical Advisory Board reviewers.
Aplastic Anemia only

Funding is available to support one project focusing on Aplastic Anemia at $80,000 over two years ($40,000 per year) judged to have the highest scientific merit by the AAMDSIF Medical Advisory Board reviewers.

Required Letter of Intent (LOI)

LOIs are required prior to submission of full application. Applicants will be invited to submit a full application based on the LOI.

Letters of intent (LOIs) will be accepted from potential applicants. The deadline for LOI submission is June 30, 2026. LOIs must be submitted via the online grant application portal proposalCENTRAL, https://proposalcentral.altum.com/.

Application

Select applicants will be invited to submit full proposals, based on review of the letters of intent. Applications will be due October 31, 2026, and must be submitted via the grant application portal proposalCENTRAL, https://proposalcentral.altum.com/

Important dates:

Grant Portal Open: April 10, 2026
Letters of Intent Submission Deadline: June 30, 2026
Applications Due: October 31, 2026
Notification of Award: Early December 2026
Funding Begins: January 1, 2027

AI Based Application Success Predictor

🧬 1. Strong Focus on Bone Marrow Failure Disorders (Top Predictor)

AAMDSIF funding is strictly targeted to:

Aplastic anemia (AA)
Myelodysplastic syndromes (MDS)
Paroxysmal nocturnal hemoglobinuria (PNH)
Related bone marrow failure conditions

👉 Proposals outside these disease areas have very low success rates

🔬 2. High Scientific Merit (Primary Selection Criterion)

Grants are awarded to projects with:
- Highest scientific quality
- Strong hypothesis and rigorous design
Reviewed by a Medical Advisory Board

👉 Scientific merit is the most decisive factor in funding decisions

🔄 3. Translational & Therapeutic Relevance (Critical)

AAMDSIF supports:

Basic → translational → clinical continuum
Strong preference for:
- New therapeutic approaches
- Drug development
- Early-stage clinical research

👉 Projects must show how they advance treatment or patient outcomes

🧪 4. Mechanistic Understanding of Disease Biology

Successful proposals often:

Investigate:
- Genetic mutations
- Bone marrow failure mechanisms
Aim to improve:
- Disease classification
- Personalized therapies

👉 Mechanistic insight is key to improving therapies

👶 5. Emphasis on Genetic & Pediatric Research (Emerging Priority)

Dedicated funding areas include:
- Pediatric bone marrow failure
- Genetic determinants of disease
Focus on:
- Personalized medicine approaches

👉 Projects linking genetics → therapy have higher success

🎯 6. Clear Clinical Impact Pathway

Proposals should demonstrate:
- Potential to improve:
  - Diagnosis
  - Treatment
  - Survival

👉 Even basic research must show clinical relevance

⚖️ 7. Feasible, Focused Project Scope

Typical funding:
- ~$60,000 over 2 years
Projects must be:
- Realistic
- Achievable within limited funding

👉 Overly large or complex proposals are often rejected

👩‍🔬 8. Investigator Capability & Relevance

Experience in:
- Hematology
- Bone marrow failure research
Ability to execute:
- Preclinical or clinical studies

👉 Track record matters, especially in niche diseases

🤝 9. Collaborative & Multidisciplinary Approach

Collaboration between:
- Clinicians
- Basic scientists
- Genetic researchers

👉 Multidisciplinary projects improve translational success

📊 10. Potential to Advance the Field

AAMDSIF prioritizes projects that:

Generate:
- New knowledge
- Future funding opportunities
Contribute to:
- Long-term cures or improved therapies

👉 Grants are often seed funding for larger studies

📊 Summary: Key Predictors (Ranked)

Highest impact factors:

Strong disease-specific focus (AA/MDS/PNH)
Scientific merit
Translational/therapeutic relevance

Moderate predictors:
4. Mechanistic insight (genetics, biology)
5. Clinical impact pathway
6. Feasibility

Supporting factors:
7. Investigator expertise
8. Collaboration
9. Future research potential

💡 Insider Insight

Compared to larger hematology funders:

Aplastic Anemia and MDS International Foundation is:
👉 niche-disease focused + seed-funding oriented

👉 Key evaluation question:
“Will this research meaningfully advance understanding or treatment of bone marrow failure disorders?”

Strong disease focus ✔️
Mechanistic + translational link ✔️
Feasible pilot-scale project ✔️
→ Highest success probability

Specialties

Cancer

Eligibility Requirements

The AAMDSIF Research Grant Program is open to New Investigators only. New Investigators are post-doctoral fellows, instructors, and those who have been assistant professors for fewer than five (5) years.

Sponsor Details

Sponsor Institute/Organizations: Aplastic Anemia and MDS International Foundation

Sponsor Type: Corporate/Non-Profit

Address: 401 N. Washington Street, Suite 430 Rockville, MD 20850

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