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Eliminating Disparities in Childhood Cancers Award

Children's Cancer Research Fund

With this award, CCRF wishes to support research that reduces health disparities or inequities in childhood cancer incidence, presentation, access to care, outcome of therapy including adverse event rates, or survivorship.

Health disparities are defined here as “systemic, plausibly avoidable health differences adversely affecting socially disadvantaged groups.” (Braveman et al. 2011). CCRF will consider disparities based on race/ethnicity, sex or gender, socioeconomic status, language, geography, or other social determinants of health, so long as their evaluation is supported by the literature. Proposals that identify modifiable risk factors, elaborate mechanisms of disparities or inequities, or which plausibly propose to reduce them, will have greater priority for funding than proposals that simply describe them.

Award Information

Application Types

We will accept applications that are new or from a previous pilot study. We will also accept applications (R03, R21) that have been reviewed but not funded by the National Institutes of Health (NIH). We will also consider proposals that were awarded, but later cancelled, by the NIH as long as they correspond to the requirements of this funding mechanism. (See Resubmission of NIH Funded Applications below for additional information).

Number of Awards

Funding of awards will be dependent on the availability of funds.

Award Period

Maximum project period is 24 months.

Award Budget

A budget for total costs up to $125,000 per year may be requested. This includes indirect costs of up to 10% of direct costs.

Clarifications:

• Allowable direct costs include salaries, fringe benefits, supplies, sub-contracts, publication costs, equipment & travel expenses.

• CCRF adheres to the NIH salary cap for Principal Investigators.

• Project-related travel is allowed as needed and must be fully justified. Up to $2,000 per year for conference travel.

• All sub-contracts and collaborations must be described and well-justified.

• If utilizing a subcontract, the PI’s institution is responsible for disbursing subcontract funds.

• Any equipment to be purchased with grant funds must be well-justified.

• Indirect costs of 10% of direct costs are allowed.

AI Based Application Success Predictor

1. Potential to Improve Outcomes for Children with Cancer

The strongest predictor is whether the project can meaningfully improve prevention, diagnosis, treatment, survivorship, or quality of life for children with cancer. CCRF prioritizes research with a clear connection to improving patient outcomes.

2. Translational and Clinical Relevance

CCRF strongly supports projects that move discoveries toward patient benefit. Applications that bridge laboratory findings to clinical implementation tend to be more competitive than purely descriptive or exploratory studies.

3. Scientific Merit and Innovation

Reviewers evaluate:

Novel scientific concepts
Innovative methodologies
New technologies
Potential to change current approaches

Projects proposing transformative advances receive favorable consideration.

4. Near-Term Impact

One of CCRF's explicit review criteria is the likelihood that the project will lead to advances in prevention, diagnosis, or treatment within a realistic timeframe. Projects with a clear path to measurable progress score highly.

5. Alignment with Current CCRF Priorities

Recent CCRF funding programs emphasize:

Hard-to-treat pediatric cancers
Childhood cancer survivorship
Eliminating disparities in childhood cancer
Clinical trials
Equitable care
Mental health and long-term outcomes

Applications aligned with these themes are particularly competitive.

6. Clinical Translation Strategy

Successful proposals clearly explain:

How findings will move toward patient care
Milestones for translation
Potential future clinical studies
Barriers and implementation plans

Review criteria specifically include the overall plan for bringing findings into clinical application.

7. Investigator Qualifications

Reviewers assess:

Expertise in the proposed area
Relevant publication record
Previous productivity
Ability to execute the project successfully

Strong investigators with demonstrated experience in pediatric oncology generally have an advantage.

8. Collaboration

CCRF explicitly encourages:

Multi-institutional studies
Interdisciplinary teams
Research consortia
Academic–industry partnerships

Collaborative projects are reviewed favorably because they can address complex pediatric cancer challenges more effectively.

9. Focus on High-Unmet-Need Areas

Recent award mechanisms prioritize:

Hard-to-treat cancers
Rare pediatric tumors
Survivorship interventions
Health disparities research

Projects addressing significant unmet needs often receive special attention.

10. Research Environment

Competitive proposals demonstrate access to:

Pediatric oncology patient populations
Clinical trial infrastructure
Specialized facilities
Biostatistical support
Institutional commitment

Adequate resources are a formal review consideration.

Frequently Funded Research Themes

Recent CCRF funding opportunities have focused on:

Hard-to-treat pediatric cancers
Novel targeted therapies
Translational oncology
Pediatric clinical trials
Cancer survivorship
Late effects of treatment
Health disparities and equitable care
Precision medicine
AI and advanced technologies in pediatric oncology
Quality-of-life interventions for survivors

Funding Strategy

A highly competitive CCRF application typically includes:

A major unmet need in childhood cancer.
Strong scientific innovation.
Clear translational relevance.
Realistic potential for near-term patient impact.
Experienced investigators and collaborators.
Alignment with CCRF priorities such as hard-to-treat cancers, survivorship, or health equity.

Specialties

Cancer

Pediatrics

Oncology

Eligibility Requirements

Applicants must be eligible to serve as a Principal Investigator at their sponsoring institution.

• Applicant institutions must be based in the United States.

• Applicants are not required to be United States citizens.

• Awarded PIs are required to commit at least 10 percent of their research efforts each year to activities supported by this award.

• Submission of a Letter of Intent (LOI) is required.

• Co-Investigators and/or collaborators are permitted, but the award must be made to a single institution which will act as the grant administrator.

• Applicants’ organizations may submit more than one application, provided each application is scientifically distinct. However, CCRF will only accept one LOI from a PI each calendar year.

• Applicants should review all necessary materials and use the appropriate templates and forms. Failure to comply with the instructions provided may result in programmatic or administrative rejection of your Letter of Intent (LOI) or full application.

Eligible Countries:

United States

Sponsor Details

Sponsor Institute/Organizations: Children's Cancer Research Fund

Sponsor Type: Corporate/Non-Profit

Address: 1650 W 82nd St., Suite 400 Minneapolis, MN 55431

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