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Translational Strategies to Define, Enhance, and Monitor Vascularization for Durable Islet Replacement Therapies

Breakthrough T1D

Summary • Breakthrough T1D is launching a new funding opportunity to support translational research that advances the clinical application of vascularization- and engraftment-focused strategies for islet replacement therapy in type 1 diabetes (T1D).

• Funded projects must address at least one of the following areas: 1) define vascular features that correlate with or predict graft function and long-term durability; 2) advance strategies to enhance vascular integration, perfusion and graft resilience at extrahepatic transplant sites; or 3) advance non-invasive technologies to monitor neovascularization, perfusion, vascular stability, and oxygenation in vivo.

• This Request for Applications (RFA) will provide grants of up to $900,000 for a maximum duration of three years. Both non-profit (e.g., academic institutions) and for-profit entities (e.g., biotechnology companies) are eligible to apply

Funding Opportunity Scope

Breakthrough T1D invites Letters of Intent (LOIs) from investigators in academic and industry settings proposing strategies or technologies to enhance or monitor engraftment of islet replacement therapies in T1D. LOIs may address 1) mechanisms that govern vascular integration and maturation, 2) approaches that improve perfusion, oxygenation, and long-term function of implanted islets within extrahepatic transplant sites, or 3) non-invasive longitudinal monitoring of engraftment. Priority will be given to proposals with clear translational potential and well-defined plans for advancing toward clinical application.

Strategic Research Agreements

(SRAs) Strategic Research Agreements are intended for support of research activities at non-for-profit entities such as academic institutions. For SRAs, proposed budgets for projects should not exceed $900,000 USD total costs for up to three (3) years (including 10% indirect costs). The level of funding will vary depending on the scope, data available, need to perform additional laboratory assays, access to samples, degree of data analysis to be performed, and overall objectives of the proposal. If your project budget and/or timeline exceeds $900,000 and/or 3 years, please discuss with Breakthrough T1D staff (contact information below). For more information on the Strategic Research Agreement (SRA) grant mechanism

AI Based Application Success Predictor

While competitive specifics can vary by mechanism, proposals that win funding consistently share these strengths:

✅ 1) Alignment with Strategic Priorities

Your project must clearly connect to Breakthrough T1D’s mission — curing T1D and improving lives — or to a specific funding opportunity’s focus area (e.g., tolerance in islet replacement, monitoring technologies, clinical relevance). Breakthrough T1D+1

Tip: Explicitly justify which strategic goal(s) your work addresses in both the LOI and full proposal.

✅ 2) Clear, Impactful Scientific Rationale

Successful applications present:

A strong, evidence-based rationale for why the research matters,

Well-defined hypotheses or objectives,

Direct significance to T1D biology, clinical outcomes, or technology gaps.

Breakthrough T1D prioritizes work likely to accelerate translation toward therapy development. Breakthrough T1D

✅ 3) Feasible Study Design With Realistic Milestones

Proposals that are clearly executable in the funding timeframe—with thoughtful experimental design, milestones, and contingency planning — score higher during review.

Include:

Detailed methods

Milestones tied to measurable outcomes

A realistic timeline

✅ 4) Strong Team and Institutional Capacity

Breakthrough T1D often reviews:

Investigator track record,

Institutional resources and support,

Collaborations that enhance feasibility and reach.

Demonstrate that your team has the expertise and facilities to deliver on the proposal. Breakthrough T1D

✅ 5) Meaningful Translation and Clinical Relevance

Even for basic science, reviewers value work that lays clear groundwork for translation — for example:

Biomarkers predictive of disease progression,

Platforms or tools that shorten clinical testing,

Approaches ready for next-step clinical studies.

Make translational potential explicit in aims and impact statements.

✅ 6) Balanced Budget Justification

Grants like Innovative Awards (~$200 k/1 yr) and SRAs (up to ~$900 k/3 yrs) require budgets that are justified and aligned with deliverables. Overly optimistic or under-budgeted proposals are less competitive. Breakthrough T1D+1

✅ 7) Engagement With Stakeholders & Ethics

Where relevant (especially clinical research or novel technologies), strong ethics planning and stakeholder engagement (including patient populations) boost confidence in feasibility and impact.

✅ 8) Clear Communication & Strategic Positioning

Given the volume of submissions and variety of expert reviewers, clarity of narrative with defined aims and outcomes is crucial. Strong summary sections (abstract and lay summary) effectively ‘sell’ the project.

🧠 Grant Review Structure

Breakthrough T1D typically uses a two-stage review:

LOI screening – checks alignment and concept strength.

Full proposal review – detailed scientific and feasibility assessment. Breakthrough T1D

Some calls (e.g., Innovative Awards) may go directly to full proposal.

📌 Typical Funding Amounts & Duration

Mechanism	Award Size	Duration
Innovative Awards	Up to ~$200,000	1 year Breakthrough T1D
Strategic Research Agreements	Up to ~$900,000	Up to 3 years Breakthrough T1D UK
Mechanism-specific Calls	Varies by topic	Varies by program Breakthrough T1D

🧠 Final Summary: Breakthrough T1D Success Predictors

Top predictors of funding competitiveness:

🔹 Strong fit with Breakthrough T1D’s mission and specific call focus. Breakthrough T1D

🔹 Science with clear impact on cure pathways or life improvement. Breakthrough T1D

🔹 Feasible design with milestones and measurable outcomes.

🔹 Experienced research team and institutional support.

🔹 Translational vision connecting bench progress to real-world outcomes.

🔹 Well-justified, realistic budget.

🔹 Communicative clarity and strategic narrative.

Specialties

Vascular Surgery

Eligibility Requirements

Applications may be submitted by domestic and foreign non-profit organizations, public and private, such as universities, colleges, hospitals and laboratories, units of state and local governments and eligible agencies of the federal government, for-profit entities, or industry collaborations with academia. Applicants must hold an MD, DO, DMD, DVM, PhD, or equivalent and have a faculty position or equivalent at a college, university, medical school, or other research facility.

Please note that applications from for-profit entities or industry collaborations with academia may be submitted in response to this RFA. Additional information will be requested from for-profit entities if invited to submit a full proposal.

There are no citizenship requirements for this program. To assure continued excellence and diversity among applicants and awardees, Breakthrough T1D welcomes applications from all qualified individuals and encourages applications from persons with disabilities, women, and members of minority groups underrepresented in the sciences.

Sponsor Details

Sponsor Institute/Organizations: Breakthrough T1D

Sponsor Type: Corporate/Non-Profit

Address: 200 Vesey Street, 28th Floor, New York, NY 10281

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