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Single Ventricle Research Fund (SVRF)

Additional Ventures

Our flagship funding program — the Single Ventricle Research Fund (SVRF) — is an annual research award program that supports foundational studies aimed at improving outcomes for individuals with single ventricle heart disease. By addressing the organ- and multi-organ-level complications and clinical sequelae that drive long-term morbidity and mortality, the SVRF seeks to close critical gaps in understanding and treatment, and accelerate progress toward better, more predictive, and preventative care.

Applicants may apply for either the Independent Investigator or Career Development tracks. The Independent Investigator Track is open to both tenure and non-tenure track independent investigators, including instructors, assistant professors, and tenured faculty. The Career Development Track is open to postdoctoral fellows or postdoc equivalents who hold mentored positions. Independent Investigator Track applicants can apply for up to $600,000 in direct costs, and Career Development Track applicants may apply for up to $300,000 in direct costs, over 3 years.

In its sixth cycle, the SVRF welcomes foundational research that is directly relevant to improving outcomes for individuals with single ventricle heart disease.

Who Fits

Proposed projects must be led by principal investigator(s) who hold doctoral degrees (e.g. PhD, MD, PsyD, or equivalent doctorates). Proposals are accepted for two program tracks: Independent Investigator and Career Development.

Independent Investigator Track: Eligible investigators include independent investigators of all levels (including those with Instructor or Assistant Professor status). Collaborative proposals (e.g., includes multiple lead investigators who make significant contributions) are encouraged. One principal investigator must be selected as the primary contact, with all other lead investigators listed as co-investigators. Up to five (5) co-investigators may be added to each project, and they must meet the same eligibility requirements as the principal investigator.

Career Development Track: Eligible investigators include postdoctoral fellows or equivalents holding a mentored position. Collaborative proposals will not be accepted through this track.

What Fits

Through the SVRF, Additional Ventures aims to accelerate foundational research that will lead to improved care and new therapeutic opportunities grounded in a mechanistic understanding of single ventricle heart disease.

The 2027 SVRF welcomes research aligned with the focus areas and strategic topics described in the Additional Ventures’ 2026 Research Roadmap. We are particularly interested in proposals that seek to elucidate the mechanisms underlying, prevent, or reverse the interrelated organ- and multi-organ-level sequelae that contribute to long-term morbidity and mortality.

Proposals may address the following Roadmap domains:

DOMAIN I: Add Back a Pump

Build A Biological Pump
Build a Mechanical Ventricle

DOMAIN II: Address Sequelae

I. Systemic Circulatory Regulation
Lymphatic and Immune Equilibrium
Liver Health
Kidney and Gut Perfusion
Cardiac Integrity and Rhythm Stability
Neurodevelopment

*Projects within Domain I are eligible when they are primarily hypothesis-driven investigations of the biological, physiological, or engineering principles required to restore or support circulatory function. Applications focused primarily on device design, prototype development, product optimization, or precommercial testing are not within the scope of this award mechanism. These proposals may be eligible for funding through an alternative Additional Ventures funding mechanism.

This award exclusively supports foundational research projects that aim to improve our mechanistic understanding of single ventricle heart disease. Registry and biorepository build, and clinical trials will not be considered.

Through the SVRF program, Additional Ventures is committed to advancing foundational research that drives meaningful improvements in outcomes for people living with single ventricle heart disease. While we recognize that understanding disease origins can inform innovation, all supported work must clearly connect these insights to the complications and sequelae that shape long-term survival and quality of life.

Deadlines are subject to change at the discretion of Additional Ventures in response to nationally or globally related events.

Previous SVRF Cycles

Historically, the SVRF has selected 14-17 proposals each year and has collectively awarded almost $56M to support single ventricle research. View our list of funded studies for additional information on our SVRF awardees.

Award Amount

Up to $600,000 in direct costs for the Independent Investigator Track awards. The Career Development Track awards are eligible for up to $300,000 in direct costs. Awards under both tracks span over three (3) years. Indirect costs up to 10% will be provided in addition to the total funded amount.

AI Based Application Success Predictor

1	Scientific and technical merit	Strong scientific rationale, research quality, and technical soundness.
2	Single ventricle disease relevance	Direct alignment with single ventricle heart disease and its associated complications.
3	Research innovation	Novel approaches addressing important gaps in understanding, treatment, and prevention.
4	Multidisciplinary collaboration	Collaboration across clinical, biomedical, engineering, and other scientific disciplines.
5	Investigator expertise	Relevant research experience, qualifications, and capabilities of the research team.
6	Early-career investigator development	Potential to develop independent researchers and support career progression.
7	Research feasibility	Realistic research aims, methodology, milestones, and timeline.
8	Translational potential	Potential to translate foundational discoveries into improved clinical care.
9	Cost realism	Appropriate budget, cost justification, and responsible resource allocation.
10	Commitment to scientific community	Collaboration, leadership development, training, and contribution to the single ventricle research community.

These factors are based on Additional Ventures' published review criteria and funding priorities, rather than a statistically validated ranking of historical award-winning factors.

additionalventures.org+2

Organization and funding classification

Category	Details
Organization type	Private philanthropic foundation
Country	United States
Government/Federal or Non-Profit/Corporate	Non-profit philanthropic funder; non-governmental
Primary research areas	Congenital heart disease, single ventricle heart disease, cardiovascular research, cardiac regeneration, and multi-organ complications.
Major grant programs	Single Ventricle Research Fund (SVRF), Catalyst to Independence Award, Device Innovation Award, Expansion Award, and AHA/AV Collaborative Sciences Awards. Additional Ventures+1
Historical research investment	More than $95 million in single ventricle research funding and support for more than 200 studies, according to its current website. Together, we can cure single ventricle.
Historical success rate	Not verified; comparable application and award counts are required.

Excel-ready entry — Previous Success Predictors

Scientific and technical merit; single ventricle heart disease relevance; research innovation; multidisciplinary collaboration; investigator expertise; early-career development; methodological rigor; research feasibility; translational potential; realistic budget; leadership development; and commitment to the scientific community.

Specialties

Cardiothoracic Surgery

Cardiovascular Diseases

Eligibility Requirements

Career Development Track: Eligible investigators include postdoctoral fellows or equivalents holding a mentored position. Collaborative proposals will not be accepted through this track.

Sponsor Details

Sponsor Institute/Organizations: Additional Ventures

Sponsor Type: Corporate/Non-Profit

Address: 314 Lytton Ave, Palo Alto, CA 94301

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