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Single Ventricle Research Fund (SVRF)

Additional Ventures

Our flagship funding program — the Single Ventricle Research Fund (SVRF) — is an annual research award program that supports foundational studies aimed at improving outcomes for individuals with single ventricle heart disease. By addressing the organ- and multi-organ-level complications and clinical sequelae that drive long-term morbidity and mortality, the SVRF seeks to close critical gaps in understanding and treatment, and accelerate progress toward better, more predictive, and preventative care.

Applicants may apply for either the Independent Investigator or Career Development tracks. The Independent Investigator Track is open to both tenure and non-tenure track independent investigators, including instructors, assistant professors, and tenured faculty. The Career Development Track is open to postdoctoral fellows or postdoc equivalents who hold mentored positions. Independent Investigator Track applicants can apply for up to $600,000 in direct costs, and Career Development Track applicants may apply for up to $300,000 in direct costs, over 3 years.

In its sixth cycle, the SVRF welcomes foundational research that is directly relevant to improving outcomes for individuals with single ventricle heart disease.

Award Amount

Up to $600,000 in direct costs for Independent Investigator Track awards, up to $300,000 for Career Development Track awards, over three (3) years. Indirect costs up to 10% will be provided in addition to the total funded amount.

Deadlines

Letters of intent due:

October 8, 2025

Full proposal invitations:

By November 18, 2025

Full proposal due (invite only):

January 14, 2026

Awardees announced:

By June 20, 2026

Anticipated funding:

July 1, 2026

AI Based Application Success Predictor

1. Big Picture + Global or Systemic Impact — Not Just Incremental Gains

Because Additional Ventures aims for transformative change, strong proposals tend to:

Address global or large-scale problems (e.g., structural risk, climate change, global health inequities, systemic resilience) rather than narrow, localized issues.

Propose solutions or interventions with scalability, long-term sustainability, or policy-level change, rather than small-scale pilot fixes.

Offer a vision of significant leverage — how initial investment can lead to amplified impact over time.

Predictor: The more your proposal aims at systemic/global impact, the stronger.

2. Forward-Thinking, Innovative, “Moonshot” or High-Risk / High-Reward Ideas

Additional Ventures is known to fund ideas outside the mainstream — including early-stage, speculative, or high-risk/open-ended projects. Therefore:

Novel, unconventional, or cross-disciplinary ideas are welcomed.

Projects that might not yet have robust preliminary data but show promise for breakthroughs — especially if the potential upside is large — can be competitive.

Flexibility and ambition are valued over conservatism.

Predictor: Bold, innovative ideas — especially those addressing long-term risk or systemic challenges — are more likely to resonate.

3. Strong Theory or Rationale, with Credible Planning & Scalability

Even with high-risk or early-stage ideas, proposals should include:

A clear conceptual framework or rationale — why the idea could work, what makes it promising.

A feasible plan for initial development, proof-of-concept or early implementation, with defined milestones.

Consideration of scalability, sustainability, dissemination, or policy translation (as appropriate).

Predictor: A well-thought-out plan bridging ambition with reasoned feasibility enhances credibility.

4. Measurable Impact Metrics or Long-Term Outcome Vision

Given the foundation’s focus on “impact,” proposals that define:

Clear, measurable short-term outputs or intermediate metrics; and

A credible chain of causation to long-term societal outcomes

are more competitive than those with vague aspirations.

Predictor: Concrete metrics + realistic roadmap → higher funding likelihood.

5. Interdisciplinary or Cross-Sector Collaboration

Additional Ventures often supports initiatives that cross disciplinary, sectoral, or geographic boundaries (e.g., combining science, policy, public health, technology). Strong proposals may:

Bring together diverse expertise (scientists + social scientists + policy experts + community organizations)

Combine academic research with real-world implementation or advocacy

Engage stakeholders across regions or sectors

Predictor: Interdisciplinary, collaborative efforts with broad reach tend to stand out.

6. Focus on Long-Term Outcomes — Not Just Short-Term Wins

Given the foundation’s horizon, it supports projects with long-term vision: building infrastructure, altering systems, shifting policy, or preventing existential or global risks. Projects that plan for multiyear timelines or phased development (from pilot → scale-up → institutionalization) generally align well.

Predictor: Long-term strategic thinking and sustainability focus strengthen applications.

7. Openness to Risk, Failure, and Adaptive Learning

Because many funded ideas are high-risk/high-reward, successful grantees often show:

Realistic acknowledgment of uncertainties or risks

Flexible design and adaptive learning plans (so that failure at one stage is informative and does not waste resources)

Transparency, open data or open communication, and a willingness to pivot if needed

Predictor: Demonstrating readiness to navigate risk responsibly is valued.

8. Ethical, Equitable, and Global-Justice Orientation (Especially for Global Issues)

For proposals addressing global health, climate, inequality, or governance: showing awareness of equity, inclusion, justice, and long-term social implications — especially for vulnerable populations — improves competitiveness.

Predictor: Ethical, just, and inclusive framing (not just technical) resonates with foundation values.

⚠️ What Makes Applications Less Likely to Succeed

Very narrow, incremental, or small-scale ideas with limited broader impact — especially if the proposal does not link to systemic change.

Lack of clear plan for implementation, scaling, or outcome measurement.

Overly speculative ideas without clear rationale or path to realize impact (unless extremely well-justified).

Single-discipline, siloed studies with limited collaboration or engagement.

Short-term thinking; proposals expecting “quick wins” rather than long-term change.

🎯 What This Means for You — If You Plan to Apply to Additional Ventures

If you are preparing a proposal for Additional Ventures, you should:

Frame your idea as tackling a global or systemic problem, with long-term impact and scalability.

Embrace bold, innovative thinking — don’t shy away from high-risk/high-reward ideas, especially if you can explain why they matter.

Provide a clear, realistic roadmap: from initial proof-of-concept or pilot → to scale-up or broader implementation.

Build multidisciplinary and cross-sector collaborations to strengthen feasibility and impact.

Define metrics of success, short-term and long-term, and an evaluation plan.

Show readiness for adaptive learning — able to pivot or refine the project in response to feedback or early results.

Embed equity, justice, and global-impact thinking, especially if the topic involves vulnerable populations or long-term social change.

Specialties

Clinical Trials

Eligibility Requirements

Proposed projects must be led by principal investigator(s) who hold doctoral degrees (e.g. PhD, MD, PsyD, or equivalent doctorates). Proposals are accepted for two program tracks: Independent Investigator and Career Development.

Independent Investigator Track: Eligible investigators include independent investigators of all levels (including those with Instructor or Assistant Professor status). Collaborative proposals (e.g., includes multiple lead investigators who make significant contributions) are encouraged. One principal investigator must be selected as the primary contact, with all other lead investigators listed as co-investigators. Up to five (5) co-investigators may be added to each project, and they must meet the same eligibility requirements as the principal investigator.

Career Development Track: Eligible investigators include postdoctoral fellows or equivalents holding a mentored position. Collaborative proposals will not be accepted through this track.

Sponsor Details

Sponsor Institute/Organizations: Additional Ventures

Sponsor Type: Corporate/Non-Profit

Address: 314 Lytton Ave, Suite 200 Palo Alto, CA 94301

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