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Funding Opportunity




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Senior Research Awards

Crohn's & Colitis Foundation of America

Below are the guidelines for the Crohn's & Colitis Foundation’s Senior Research Awards:

 

Submission Deadlines 
Pre-Application

Portal Opens: October 4, 2025

Deadline: December 2, 2025

11:59pm EST

Online Application (via Invitation)

January 22, 2026

11:59pm EST

Applications ReviewApril – May
Decisions AnnouncedJune

 

Objective: To provide established researchers with funds to generate sufficient preliminary data to become competitive for funds from other sources such as the National Institutes of Health (NIH).

Senior Research Awards Costs: Total maximum award per year: $130,000 (subject to annual progress report approval).

  1. Direct Costs: up to $118,182 per year
  2. Indirect Costs: 10% of direct costs, or up to $11,818
  3. Duration of Award: One to Three Years

AI Based Application Success Predictor

1. Clear Relevance to Inflammatory Bowel Disease (IBD) — Crohn’s or Ulcerative Colitis

The project must directly address IBD (mechanisms, diagnosis, therapy, quality-of-life, etc.). 

Proposals unrelated to IBD — or only weakly tied — are unlikely to be competitive.

Takeaway: Make the link to IBD explicit and central from the start.

2. Alignment With the Appropriate Funding Mechanism (Career Stage + Project Type)

CCF offers multiple funding tracks:

Student scholarships

Research Fellowships (postdoc/early-career)

Career Development Awards (early faculty)

Senior Research Awards (established investigators)

Clinical Investigator-Initiated Awards (clinical researchers)

Specialized mechanisms (e.g. “Pioneers”, “IBD Ventures”) including translational/product-development grants. 

Predictor: Select the grant track that matches your career stage and the maturity of your project. Reviewers expect appropriate scope, scale, and ambition.

3. Innovation + Addressing Unmet Needs in IBD

CCF values proposals that tackle pressing gaps — for example:

Novel therapeutic targets (beyond current biologics)

Pathways for patients unresponsive to existing therapies

Biomarkers for prognosis, disease stratification, or response prediction

Approaches for barrier repair, mucosal healing, microbiome modulation, fibrosis prevention

Digital health, patient-reported outcomes, disease monitoring tools

These match their stated long-term goal: cures and improved quality of life. 

4. Strong, Feasible Experimental or Clinical Design with Clear Aims

Competitive proposals generally have:

2–3 focused, hypothesis-driven aims

Realistic timeline (1–3 years depending on grant)

Clearly defined milestones & deliverables

Appropriate methods: preclinical models, human samples/cohorts, clinical endpoints

Clear plan for data analysis and interpretation

Overly broad, speculative, or poorly outlined proposals tend to fare poorly.

5. Solid Preliminary Data (Especially for Fellowships / Senior Awards / Translational Grants)

Although early-stage funding exists, projects with supporting pilot data (in vitro, in vivo, or clinical cohorts) stand out — demonstrates feasibility and reduces risk. This is especially critical for translational or product-development applications.

6. Access to Appropriate IBD Models, Cohorts, or Clinical Resources

Strong proposals typically leverage:

Preclinical models relevant to IBD (animal models of colitis, organoids, epithelial barrier assays)

Human patient samples (biopsy, blood, stool), or ability to recruit IBD patients

Clinical or translational infrastructure for biomarker studies or small interventional trials

Access to such resources increases confidence in deliverability.

7. Investigator Expertise, Commitment, and (for Early Awards) Mentorship / Training Environment

For early-career applicants (Fellowship / Career Development), reviewers look for:

Strong mentorship plan

Institutional support (protected time, core resources)

Clear career trajectory toward independent IBD research

For more senior applicants: consistent track record, prior publications, and capacity to lead high-impact IBD research.

8. Potential for Real-World Impact (Therapy, Diagnostics, Patient Quality of Life)

CCF prioritizes work that can translate into:

New or improved therapies

Predictive or diagnostic biomarkers

Approaches to reduce treatment failure or toxicity

Improved patient monitoring, quality of life, or disease management

Demonstrating a pathway from research to patient benefit significantly strengthens proposals.

9. Clear, Well-Written, Strategically Sound Proposals with Transparent Use of Funds

Proposals that are easy to read, logically structured, and transparent about budgets tend to score higher. Because CCF funds many small-to-medium grants, clarity and cost-effectiveness matter.

10. For Product- or Device-Focused Proposals: Embrace Translational & Entrepreneurial Vision (IBD Ventures)

CCF also supports product development (drugs, devices, diagnostics, digital tools) under IBD Ventures — funding up to US $500,000 + advising/accelerator support. 

Working on novel diagnostics, safer therapies, microbiome-based treatments, digital health solutions, or device-based IBD management can be competitive under this track — especially if you blend robust science with clear commercialization potential.

🎯 What This Means for You — Writing a Strong CCF Grant Proposal

Make IBD relevance unambiguous from title thru aims

Target the correct grant type — don’t overreach or under-scope

Articulate a clear unmet need or knowledge gap in IBD

Use focused, feasible aims with realistic timelines

Provide pilot data or strong rationale for feasibility

Show you have resources, patient access, or model systems to carry out the work

Emphasize translational potential or patient impact

For early-career grants — ensure strong mentorship and protected research time

If proposing a therapy or product — include path to development, regulatory or translational plan, and cost-effectiveness arguments

Write clearly, concisely — reviewers may read many proposals

Applicant must hold an MD and/or PhD (or equivalent degree) and must be employed by an institution (public non-profit, private non-profit, or government) that is engaged in health care and/or health-related research. He/she must have attained independence from his/her mentor. Eligibility is not restricted by citizenship or geography.

Proposal Eligibility: Proposal must be relevant to Inflammatory Bowel Disease (IBD) or Crohn's disease and/or ulcerative colitis. Only one application is allowed per applicant per submission date. Simultaneous submission of a Senior Research Award and a Training Award is not permitted.

Sponsor Institute/Organizations: Crohn's & Colitis Foundation of America

Sponsor Type: Corporate/Non-Profit

Address: 733 THIRD AVENUE, SUITE 510, NEW YORK, NY 10017

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Grant, Award

Letter Of Intent Deadline:

Jan 22, 2026

Final Deadline:

Jan 22, 2026

Funding Amount:

$130,000

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