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Career Development Awards

Crohn's & Colitis Foundation of America

Here are the guidelines for the Crohn's & Colitis Foundation’s Career Development Awards:

Submission Deadlines
Pre-Application	Portal Opens: October 4, 2025 Deadline: December 2, 2025 11:59pm EST
Full Proposal (via Invitation)	January 22, 2026 11:59pm EST
Applications Review	April – May
Decisions Announced	June

Objective: Career Development Awards are mentored awards intended to facilitate the development of individuals with research potential to prepare for a career of independent basic research investigation in the area of inflammatory bowel disease (IBD).

Stipend & Institutional Allowance: Award salary will match applicants’ institutional salary (salaries may be supplemented by the applicant’s institution), depending on postgraduate year (PGY) level, up to $60,000 per year. Fringe benefits are allowed according to institutional policies, but must not exceed 25% of the salary award (up to $15,000 per year). The Foundation will also provide up to $27,500 to be used for non-salary/fringe expenses such as an MPH degree or equivalent tuition (all degrees must be completed within the three years of this award), statistical support, travel to professional meetings, professional memberships and textbooks. These funds may not be used to supplement awardee’s salary/fringe benefits.

Salary: up to $60,000 per year
Fringe: 25% of salary, or up to $15,000 per year
Other than Personnel Service (OTPS): up to $27,500 per year
Duration of Award: One to three years
Total maximum award per year: $102,500 (subject to annual progress report approval).

AI Based Application Success Predictor

1. Clear Relevance to Inflammatory Bowel Disease (IBD) — Crohn’s or Ulcerative Colitis

The project must directly address IBD (mechanisms, diagnosis, therapy, quality-of-life, etc.).

Proposals unrelated to IBD — or only weakly tied — are unlikely to be competitive.

Takeaway: Make the link to IBD explicit and central from the start.

2. Alignment With the Appropriate Funding Mechanism (Career Stage + Project Type)

CCF offers multiple funding tracks:

Student scholarships

Research Fellowships (postdoc/early-career)

Career Development Awards (early faculty)

Senior Research Awards (established investigators)

Clinical Investigator-Initiated Awards (clinical researchers)

Specialized mechanisms (e.g. “Pioneers”, “IBD Ventures”) including translational/product-development grants.

Predictor: Select the grant track that matches your career stage and the maturity of your project. Reviewers expect appropriate scope, scale, and ambition.

3. Innovation + Addressing Unmet Needs in IBD

CCF values proposals that tackle pressing gaps — for example:

Novel therapeutic targets (beyond current biologics)

Pathways for patients unresponsive to existing therapies

Biomarkers for prognosis, disease stratification, or response prediction

Approaches for barrier repair, mucosal healing, microbiome modulation, fibrosis prevention

Digital health, patient-reported outcomes, disease monitoring tools

These match their stated long-term goal: cures and improved quality of life.

4. Strong, Feasible Experimental or Clinical Design with Clear Aims

Competitive proposals generally have:

2–3 focused, hypothesis-driven aims

Realistic timeline (1–3 years depending on grant)

Clearly defined milestones & deliverables

Appropriate methods: preclinical models, human samples/cohorts, clinical endpoints

Clear plan for data analysis and interpretation

Overly broad, speculative, or poorly outlined proposals tend to fare poorly.

5. Solid Preliminary Data (Especially for Fellowships / Senior Awards / Translational Grants)

Although early-stage funding exists, projects with supporting pilot data (in vitro, in vivo, or clinical cohorts) stand out — demonstrates feasibility and reduces risk. This is especially critical for translational or product-development applications.

6. Access to Appropriate IBD Models, Cohorts, or Clinical Resources

Strong proposals typically leverage:

Preclinical models relevant to IBD (animal models of colitis, organoids, epithelial barrier assays)

Human patient samples (biopsy, blood, stool), or ability to recruit IBD patients

Clinical or translational infrastructure for biomarker studies or small interventional trials

Access to such resources increases confidence in deliverability.

7. Investigator Expertise, Commitment, and (for Early Awards) Mentorship / Training Environment

For early-career applicants (Fellowship / Career Development), reviewers look for:

Strong mentorship plan

Institutional support (protected time, core resources)

Clear career trajectory toward independent IBD research

For more senior applicants: consistent track record, prior publications, and capacity to lead high-impact IBD research.

8. Potential for Real-World Impact (Therapy, Diagnostics, Patient Quality of Life)

CCF prioritizes work that can translate into:

New or improved therapies

Predictive or diagnostic biomarkers

Approaches to reduce treatment failure or toxicity

Improved patient monitoring, quality of life, or disease management

Demonstrating a pathway from research to patient benefit significantly strengthens proposals.

9. Clear, Well-Written, Strategically Sound Proposals with Transparent Use of Funds

Proposals that are easy to read, logically structured, and transparent about budgets tend to score higher. Because CCF funds many small-to-medium grants, clarity and cost-effectiveness matter.

10. For Product- or Device-Focused Proposals: Embrace Translational & Entrepreneurial Vision (IBD Ventures)

CCF also supports product development (drugs, devices, diagnostics, digital tools) under IBD Ventures — funding up to US $500,000 + advising/accelerator support.

Working on novel diagnostics, safer therapies, microbiome-based treatments, digital health solutions, or device-based IBD management can be competitive under this track — especially if you blend robust science with clear commercialization potential.

🎯 What This Means for You — Writing a Strong CCF Grant Proposal

Make IBD relevance unambiguous from title thru aims

Target the correct grant type — don’t overreach or under-scope

Articulate a clear unmet need or knowledge gap in IBD

Use focused, feasible aims with realistic timelines

Provide pilot data or strong rationale for feasibility

Show you have resources, patient access, or model systems to carry out the work

Emphasize translational potential or patient impact

For early-career grants — ensure strong mentorship and protected research time

If proposing a therapy or product — include path to development, regulatory or translational plan, and cost-effectiveness arguments

Write clearly, concisely — reviewers may read many proposals

Specialties

Endocrine Surgery

Endocrinology and Diabetes

Eligibility Requirements

The Foundation is sensitive to personal matters that impact career trajectories. Applicants who have taken leave from their career (e.g., parenting of a child, childbirth, long-term care of a parent/spouse/child/dependent, personal health issues), or have been impacted by the COVID-19 pandemic in a way that puts them outside of the eligibility time frame, should feel free to reach out to Foundation staff ahead of their application submission. We aim to be flexible and adjust these time frames if necessary and appropriate. This can be captured in the applicant's cover letter.*

Individuals who are already well established in the field of IBD research are not considered eligible for this award. Applicants should identify a senior investigator to act as a mentor to facilitate the transition to independence. At the time of application, applicants must be employed by an institution (public non-profit, private non-profit, or government) engaged in health care and/or health related research within the United States. Research is not restricted by citizenship; however, proof of legal work status is required. Applicants must hold an MD and/or PhD (or equivalent degree). Candidates holding MD degrees must have five years of experience after receiving their terminal degree—two years of which must be documented research experience relevant to IBD. Applicants holding PhDs must have at least two years of documented post-doctoral research relevant to IBD. Generally, candidates should not be in excess of ten years beyond the attainment of their doctoral degree.

Proposal Eligibility: Proposal MUST be relevant to IBD (Crohn's disease and/or ulcerative colitis) and must contain a career development plan detailing a training plan, mentorship plan, and describe how receiving this award will facilitate the transition to independence. Only one application is allowed per applicant per submission date. Simultaneous submission of a Senior Research Award and Training Award is not permitted.

Sponsor Details

Sponsor Institute/Organizations: Crohn's & Colitis Foundation of America

Sponsor Type: Corporate/Non-Profit

Address: 733 THIRD AVENUE, SUITE 510, NEW YORK, NY 10017

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