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Research Grant

National MPS Society

The Board of Directors has authorized up to $785,000 in new research funding for 2026. Parties interested in applying to this program are strongly encouraged to contact scott@mpssociety.org.

Choose the Right Funding Path for Your Research

The National MPS Society supports multiple research grant tiers tailored to the complexity and impact of the project. Explore the funding mechanisms below to find the opportunity that best fits your research goals.

To provide researchers and reviewers with the predictability of a fixed grant submission calendar—while maintaining flexibility to offer multiple opportunities throughout the year—the Society offers recurring grant proposal submission cycles. As each cycle progresses, the details of a subsequent call may be adjusted, or a call may be canceled, based on the outcomes of the prior cycle. Dates and additional details are provided below.

Cycle I

Announcement of Cycle Research Initiatives:

February 20, 2026

Tier I, II, and III and Fellow Initiated Letter of Intent (LOI) Due:

March 13, 2026

Invitation to Submit Full Proposals:

April 10, 2026

Invited Tier I, II, or III, and Fellow Initiated Proposals Due:

May 22, 2026

Grant Award Notification:

July 3, 2026

Start Date of Research

August 7, 2026

Cycle II

Announcement of Cycle Research Initiatives:

July 17, 2026

Tier I, II, and III and Fellow Initiated Letter of Intent (LOI) Due:

August 7, 2026

Invitation to Submit Full Proposals:

August 21, 2026

Invited Tier I, II, or III, and Fellow Initiated Proposals Due:

October 2, 2026

Grant Award Notification:

November 6, 2026

Start Date of Research

December 18, 2026

Budgetary Restrictions

Indirect Costs: Not permitted, except for specific non-profit institutions lacking tenure and endowment, subject to negotiation and documentation.
Tuition: Not allowed.
Principal Investigator (PI) Salary: Not allowed for PIs or faculty eligible to serve as PI, except under defined exceptions.
Equipment: Purchases over $5,000 are not permitted, except in Tier I proposals with prior approval (limit of one item between $5,000 and $10,000 directly related to the project).
Conference Travel: Limited to 2% of the total grant; must be for reporting Society-funded research. Travel integral to research is not limited.
Fellow-Initiated Grants: Must allocate 75% of the award to fellow salary support unless the fellow is supported by another training grant covering at least 75% of their salary and allowing uncommitted time for the proposed research.

Application Restrictions

One Application per Lab per Cycle: Only one research grant application per independent laboratory group within an institution may be submitted per cycle. Non-compliance may result in permanent disqualification.

Participation Requirements

Annual Family Conference: PIs or designated lab members are required to attend and present at the National MPS Society's Annual Family Conference once during the award period or within one year after. If in-person attendance is not feasible, a video presentation may be required. Fellow grantees must fulfill this obligation within the year of their award, unless the Notice of Grant Award is within one month of a scheduled conference, in which case attendance at the following year's conference is acceptable.

AI Based Application Success Predictor

1. Direct relevance to MPS or ML disorders (highest predictor)

This is the most important criterion.

The Society exclusively funds research focused on:

MPS I, II, III, IV, VI, VII, IX
Other MPS syndromes
Mucolipidosis (ML II/III)
Lysosomal storage disease mechanisms
Disease-specific unmet needs

Projects must clearly address an important scientific, clinical, or therapeutic question related to MPS or ML.

2. Potential to improve treatment, care, or disease outcomes (very high predictor)

The Society's funding mission is strongly patient-centered.

Competitive proposals often aim to:

Develop new therapies
Improve existing therapies
Enhance diagnosis
Improve long-term outcomes
Address neurological manifestations
Improve quality of life
Reduce disease burden

Projects with a realistic path toward patient benefit are highly favored.

3. Addressing critical unmet needs (very high predictor)

The Society explicitly highlights support for projects targeting major unmet needs in MPS and ML.

Examples include:

CNS-targeted therapies
Gene therapy approaches
Enzyme delivery challenges
Biomarker development
Rare syndrome-specific gaps
Natural history studies
Therapeutic monitoring

Projects that tackle barriers not adequately addressed by existing therapies often receive strong consideration.

4. Innovation and scientific significance

The National MPS Society repeatedly encourages innovative research and supports projects that may advance the field substantially.

Strong proposals often include:

Novel therapeutic approaches
Gene editing technologies
New enzyme engineering strategies
Innovative biomarker platforms
Precision medicine approaches
Disease-modifying interventions

Innovation is especially important for Tier I and Challenge-type proposals.

5. Strong feasibility and rigorous study design

Applications are reviewed for scientific quality and likelihood of success.

Competitive proposals generally demonstrate:

Clear hypothesis
Appropriate methodology
Realistic milestones
Statistical rigor
Achievable objectives
Well-justified budget

The Society offers funding tiers matched to project complexity, so reviewers expect scope to align with the requested funding level.

6. Potential to generate translational progress

The Society consistently emphasizes moving discoveries toward clinical impact.

Strong applications often demonstrate potential for:

Clinical trial readiness
New therapeutic strategies
Regulatory advancement
Biomarker qualification
Improved patient management

Projects bridging laboratory discoveries and clinical implementation tend to be highly competitive.

7. Early-career investigator development and mentorship

The Society maintains a dedicated Fellow-Initiated Research Grant mechanism supporting:

PhD candidates
Medical students taking research years
Postdoctoral fellows
Early-career clinician-scientists

Successful applications typically include:

Strong mentor support
Structured training plan
Career-development goals
Access to appropriate research infrastructure

Mentorship quality is particularly important for fellow-initiated applications.

8. Collaboration and use of patient resources

The Society has invested heavily in:

Global scientific collaboration
Patient registries
Clinical networks
Biospecimen resources
Rare disease infrastructure

Projects leveraging multicenter collaborations, registries, or shared resources often have a competitive advantage.

9. Potential for future NIH, industry, or foundation funding

The Society frequently serves as a catalyst for larger research programs.

Competitive projects often:

Generate pilot data
Establish proof-of-concept
Enable future NIH applications
Support industry partnerships
Create new therapeutic pipelines

Reviewers are likely to favor projects that can attract follow-on funding and accelerate progress in the field.

Specialties

Others

Eligibility Requirements

Any domestic U.S. or foreign, public or private, non-profit or for-profit research organization is eligible to apply for and receive a Society Research Grant.

Sponsor Details

Sponsor Institute/Organizations: National MPS Society

Sponsor Type: Corporate/Non-Profit

Address: P.O. Box 14686 Durham, NC 27709-4686

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