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Postdoctoral fellowships TSC Alliance

TSC Alliance

The TSC Alliance is dedicated to creating a future where everyone affected by tuberous sclerosis complex (TSC) can live their fullest lives. We invest in early-career researchers to drive innovative TSC research and to foster a diverse group of researchers dedicated to our shared mission. In 2024, we anticipate awarding three or four awards to postdoctoral fellows and early-stage investigators depending on merit, requested budgets, and funds available. A description of research funded previously is available on the TSC Alliance

Postdoctoral Fellowship awards may support any type of basic or translational research relevant to TSC that provides an outstanding opportunity for the trainee’s professional growth.
Postdoctoral Fellowship awards are intended to provide funding for an individual who has recently earned a PhD or MD degree and is working with a Sponsor to perform research relevant to TSC.
The Sponsor must be tenure-track faculty or an equivalent level at a research institution or company. The award is intended to fund the applicant’s salary and some of the laboratory supplies or tools necessary to conduct the proposed research. The award is not intended to fund technical support for the project or to purchase equipment in the Sponsor’s laboratory. The trainee applicant is considered to be the “Principal Investigator” for the purpose of postdoctoral fellowship awards.

Award Budget and Project Period

All Applicants

• The maximum project period is two years. The project period may be shorter if appropriate for the project.

• The maximum total costs are $75,000 per year and $150,000 total, inclusive of both direct and indirect costs.

• Indirect costs may not exceed 10% of the total cost ($7,500 per year or $15,000 total).

• Up to $2,000 total may be allotted toward travel expenses to support the applicant’s professional development.

Postdoctoral Fellowship Applicants

• Postdoctoral fellowship awards may support any type of basic or translational research relevant to TSC that provides an outstanding opportunity for the trainee’s professional growth.

• Postdoctoral fellowship awards are intended to fund the applicant’s salary and some of the laboratory supplies or tools necessary to conduct the proposed research.

• Postdoctoral fellowship awards are not intended to fund technical support for the project or to purchase equipment in the Sponsor’s laboratory.

AI Based Application Success Predictor

Based on funding priorities and research trends:

🥇 1. Direct Relevance to TSC (Top Predictor)

Must clearly address:
- TSC biology
- Symptoms (epilepsy, tumors, neurodevelopmental issues)

✔ Strong disease focus is mandatory

🥈 2. Therapeutic Development Potential

Highest priority:
- Projects leading to new treatments

✔ High success:

Drug development
Clinical trials

🥉 3. Translational Impact

Preference for:
- Bench-to-bedside research

✔ Projects with clinical applicability perform best

4. Mechanistic Understanding (mTOR Pathway Focus)

Strong emphasis on:
- Molecular mechanisms

✔ Especially:

TSC1/TSC2 mutations
mTOR signaling

5. Use of Patient Data / Clinical Cohorts

Preferred:
- Registries
- Clinical datasets

6. Feasibility & Milestone-Based Design

Typically:
- Structured funding

✔ Requires:

Clear deliverables

7. Collaboration (Multicenter Advantage)

Strong proposals involve:
- Clinical networks
- Multiple institutions

8. Innovation in Rare Disease Research

Competitive proposals include:
- Novel targets
- Precision medicine approaches

🧪 Common Funded Research Areas

Epilepsy in TSC
mTOR pathway and targeted therapies
Neurodevelopmental disorders (autism, cognition)
Tumor biology (renal, brain lesions)
Biomarkers and imaging
Clinical trials

⚠️ Common Reasons for Rejection

Weak relevance to TSC
Lack of therapeutic focus
Pure basic research without translation
Poor feasibility
No clear patient impact

🧠 Bottom Line (Key Predictors Ranked)

Direct relevance to TSC
Therapeutic development potential
Translational/clinical impact
Mechanistic insight (mTOR focus)
Feasible, milestone-driven design
Collaboration and clinical data use

✔️ In short:
TSC Alliance funding favors translational, therapy-focused research aimed at improving treatment and outcomes for TSC patients.

Specialties

Clinical Trials

Eligibility Requirements

• Postdoctoral fellowship applicants must be working with and mentored by a Sponsor to do research relevant to TSC. The Sponsor must be tenure-track faculty, or an equivalent level at a research institution or company.

• The trainee applicant is considered the “Principal Investigator” for the purpose of postdoctoral fellowship awards.

• Postdoctoral fellowship applicants must have been a member of the Sponsor’s laboratory for at least 12 months as of the LOI due date.

• Previous recipients of a TSC Alliance Postdoctoral Fellowship are not eligible to receive a second TSC Alliance Postdoctoral Fellowship award, but they may be eligible to receive a Research Grant as an independent, early-stage investigator.

• Previous recipients of a TSC Alliance Biosample Seed Grant are eligible to receive a Postdoctoral Fellowship if they meet other eligibility criteria.

Sponsor Details

Sponsor Institute/Organizations: TSC Alliance

Sponsor Type: Corporate/Non-Profit

Address: 8737 Colesville Road, Suite 400 Silver Spring, Maryland 20910-3921 USA 800.225.6872 (Toll-Free) 301.562.9890 info@tscalliance.org EIN: 95-3018799

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