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Funding Opportunity




  Verified

Childhood Eczema Challenge Grant

National Eczema Association

Nearly 10 million U.S children under the age of 18 are affected by eczema, with one‐third affected by moderate‐to‐severe disease. Despite recent therapeutic advances, the burdens on these patients, and their families, can be significant and many important research questions remain unanswered.  

To address this need, the National Eczema Association (NEA) and the Pediatric Dermatology Research Alliance (PeDRA) are collaborating to support targeted clinical research investigations focused on pediatric eczema with the Childhood Eczema Challenge Grant. Through this grant NEA and PeDRA intend to accelerate research that improves the health and quality of life of pediatric eczema patients and their families.  

Focus

This Challenge Grant is intended to stimulate early and mid-career scientists as they seek to build and sustain careers as research investigators and future thought leaders within this critical field of study.  Research proposals should address at least one of the following priorities related to pediatric eczema:

  • Eczema Heterogeneity: Novel Insights
    Projects aimed at advancing understanding of the underlying factors contributing to the diversity of pediatric eczema clinical presentation, treatment response and comorbidities.
  • Innovations in Clinical Practice & Care
    Studies addressing approaches to facilitate optimal identification and treatment of pediatric eczema and associated comorbidities in all health care settings to enhance patient/caregiver-reported and patient/caregiver-centric outcomes.  
  • Understanding & Alleviating Disease Burden
    Insightful proposals that identify, quantify, or aim to reduce aspects of pediatric eczema burden that negatively affect patient or family/caregiver quality of life (including lifestyle, academic, occupational, or economic impacts) based on patient population, treatment approach, etc.
  • Eczema Prevention
    Novel investigations into the potential risk factors and strategies of primary eczema prevention in the pediatric population.

Priority will be given to proposals that focus on clinical or translational research, are broadly applicable, and include a patient-centered or comparative effectiveness framework. Applications that support NEA’s and PeDRA’s commitment to advancing equity, diversity, and inclusion across all facets of their organizations and research are encouraged.  Proposals that include basic research will be accepted, however, they should be combined with a significant clinical or translational component. Proposals related to the development or enhancement of mobile apps will not be accepted. 

Number of Awards

This is a 1-year non-renewable grant. Awards are contingent on the receipt of sufficiently meritorious applications. Number of awards annually is at NEA and PeDRA’s discretion

Budget

Applicants may request up to $50,000 (USD; direct costs only). Indirect costs are not allowed.  Salary and fringe benefit support is allowed. Staff salary support should be commensurate with the percent effort dedicated to the project and explained in budget justification. PI salary support must adhere to the current allowable NIH salary cap.

AI Based Application Success Predictor

1. Strong Alignment with NEA Research Priorities (Strongest Predictor)

NEA funds projects that address its core research priorities, including:

  • Cutting-edge basic and translational science
  • Eczema heterogeneity and disease mechanisms
  • Innovations in clinical care
  • Disease burden and quality of life
  • Eczema prevention

Applications clearly linked to these priorities consistently align best with NEA funding objectives.

2. Meaningful Impact for Patients

NEA places substantial emphasis on improving the lives of people living with eczema.

Highly competitive proposals often address:

  • Itch and symptom burden
  • Quality of life
  • Mental health impacts
  • Long-term disease management
  • Pediatric outcomes
  • Patient care improvements

Many funded projects focus directly on outcomes that matter to patients and families.

3. Innovation and Scientific Merit

Successful applications typically demonstrate:

  • Novel hypotheses
  • Innovative methodologies
  • Strong mechanistic insight
  • Potential to advance eczema science

NEA repeatedly highlights support for "creative scientific ideas" and innovative research approaches.

4. Alignment with the Appropriate Grant Mechanism

NEA offers different grants for different investigator stages:

  • Engagement Grant – exploratory and pilot projects
  • Catalyst Grant – early-career investigators building independence
  • Champion Grant – established investigators addressing major eczema questions
  • Childhood Eczema Challenge Grant – pediatric eczema research
  • Spotlight Grant – specific priority topics

Applications that fit the purpose of the chosen mechanism tend to be more successful.

5. Translational Potential

NEA funds both basic and clinical science but strongly values research that may ultimately lead to:

  • Better therapies
  • Improved prevention strategies
  • Enhanced diagnostics
  • Improved patient management

Projects that bridge laboratory findings and clinical application are often well received.

6. Career Development Potential

For Engagement and Catalyst grants, NEA specifically aims to develop the next generation of eczema researchers.

Successful early-career applicants often demonstrate:

  • Strong scientific promise
  • Clear career trajectory
  • Commitment to eczema research
  • Potential for research independence

 

7. Strong Methodology and Feasibility

Competitive applications generally include:

  • Clear hypotheses
  • Appropriate study design
  • Robust statistical plans
  • Realistic timelines
  • Feasible recruitment or experimental approaches

Feasibility remains important across all grant categories.

8. Patient-Centered Outcomes Research

NEA has increasingly emphasized research that reflects patient experiences and priorities.

Examples include:

  • Psychosocial burden
  • Quality-of-life measures
  • Treatment experiences
  • Educational interventions
  • Long-term disease impacts

Patient-centered outcomes research has been highlighted in recent NEA funding programs.

9. Potential for Follow-On Funding

A notable characteristic of NEA-funded investigators is their ability to obtain larger grants after receiving NEA support.

NEA reports that more than one-third of awardees subsequently received NIH funding, making future funding potential an important implicit success factor.

10. Strong Research Environment

Successful applications often come from institutions with:

  • Dermatology expertise
  • Allergy/immunology programs
  • Translational research infrastructure
  • Strong mentorship
  • Access to patient populations

Institutional support increases confidence in successful project completion.

Frequently Funded Research Themes

Recent NEA-funded projects have focused on:

  • Skin barrier dysfunction
  • Itch mechanisms
  • Neuroimmune signaling
  • Microbiome research
  • Genetic drivers of eczema
  • Pediatric eczema
  • Psychosocial burden
  • Long-term treatment safety
  • Disease heterogeneity
  • Novel therapeutic targets
  • Prevention strategies
  • Patient-reported outcomes 

Funding Strategy

A highly competitive NEA application typically includes:

  1. A research question directly related to eczema.
  2. Strong alignment with NEA's funding priorities.
  3. Clear patient relevance and potential health impact.
  4. Innovative but feasible methodology.
  5. Strong investigator qualifications relative to career stage.
  6. A realistic path toward improved treatment, prevention, or understanding of eczema.
  7. Potential to generate future external funding and long-term advances in eczema care.

Early and mid‐career investigators (Associate Professor level or below and within 15 years of finishing training) are eligible to apply. Applicants need not be trained in pediatric dermatology but must hold the degree of MD and/or PhD (or equivalent) and be eligible to apply for grants under the guidelines of their host institution. Applications may be submitted by either a single investigator or multiple investigators at multiple institutions. Applicants need not be United States citizens and the research need not be conducted in the United States. Applicants may not hold current R‐level funding from NIH (or equivalent) as PI or Co‐PI, however recipients of past or current NEA and/or PeDRA grants are eligible to apply. 

Sponsor Institute/Organizations: National Eczema Association

Sponsor Type: Corporate/Non-Profit

Address: 505 San Marin Drive, Suite B300, Novato, CA 94945

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Grant

Letter Of Intent Deadline:

Aug 14, 2026

Final Deadline:

Aug 14, 2026

Funding Amount:

$50,000

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