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Pilot-Feasibility Research Awards

The LAM Foundation

Projects may request up to $50,000 for one year of support.

This pilot award provides funds to encourage the development and testing of new hypotheses and/or new methods in research areas relevant to LAM. The proposed work must be hypothesis generating or hypothesis testing, reflecting innovative approaches to important questions in LAM research or development of novel methods, and providing sufficient preliminary data to justify the Foundation’s support. Results from Pilot and Feasibility Grants should have the potential to lead to the submission of applications for funding from other agencies (e.g., NIH). The award is not intended to support the continuation of programs initiated under other granting mechanisms.

• Proposals will be reviewed, critiqued, scored, and voted upon by scientific and patient reviewers, whose input will be equally regarded.

• The project period for all must begin January 15, 2027.

• All materials must be submitted in English, in Arial size 11 font, with ½ inch margins.

• Only one LOI may be submitted by the same research laboratory or research group

AI Based Application Success Predictor

🫁 1. Strict Focus on Lymphangioleiomyomatosis (LAM) (Non-Negotiable)

Projects must directly address:
- Lymphangioleiomyomatosis (LAM), a rare progressive lung disease
Includes:
- Disease mechanisms
- Treatment strategies
- Clinical management

👉 Non-LAM respiratory or oncology research → not competitive

🎯 2. Clear Clinical Impact & Patient Benefit (Top Predictor)

Core mission:
- Improve outcomes and quality of life for LAM patients
Successful proposals:
- Show direct benefit to:
  - Symptoms
  - Disease progression
  - Patient care

👉 Key question:
“Will this improve treatment or quality of life for people with LAM?”

🔄 3. Strong Translational Pathway (Critical)

The foundation funds:
- Basic + translational + clinical research
But expects:
- Clear progression toward:
  - Therapies
  - Clinical trials

👉 Projects should lead to:

New treatments
Improved clinical strategies

💊 4. Focus on Therapeutic Development (High Priority)

Key priority area:

Discovering new treatments for LAM

Includes:

New drug targets
Drug repurposing
Combination therapies (e.g., with mTOR inhibitors)

👉 Treatment-focused proposals have high success rates

🧬 5. Innovation & Breakthrough Potential

Encourages:
- Innovative, hypothesis-driven research
Includes:
- Novel mechanisms
- New experimental approaches

👉 Incremental research is less competitive

🧪 6. Feasible, Short-Term, High-Yield Projects (Major Constraint)

Typical funding:
- ~$25K–$50K (pilot/clinical awards)
- Duration: ~1 year

👉 Must demonstrate:

High probability of tangible results quickly

📊 7. Strong Potential for Follow-On Funding

Grants are designed to:
- Generate preliminary data for NIH or larger trials
Expected outputs:
- Clinical trial proposals
- New methodologies
- Publishable data

👉 Clear next-step pathway is critical

👩‍🔬 8. Hypothesis-Driven, Scientifically Rigorous Design

Required:
- Clear hypothesis
- Strong methodology
Even pilot projects must:
- Demonstrate scientific rigor

👉 Weak design = common rejection reason

👥 9. Patient-Centered & Quality-of-Life Research (Unique Strength)

Dedicated funding for:
- Quality of life improvement studies
Must:
- Address unmet patient needs
- Include meaningful real-world outcomes

👉 Inclusion of patient perspective strengthens proposals

🤝 10. Collaboration with Clinical & Research Networks

The foundation:
- Connects researchers with:
  - Patient data
  - Biospecimens
Encourages:
- Multidisciplinary collaboration

👉 Access to LAM patients and datasets improves feasibility

📑 11. Strong Letter of Intent (LOI) (Gatekeeper Stage)

Mandatory process:
1. LOI submission
2. Invitation to full proposal

👉 Only top LOIs advance → clarity and alignment are crucial

📊 Summary: Key Predictors (Ranked)

Highest impact factors:

LAM-specific focus
Clinical/patient impact
Translational pathway

Moderate predictors:
4. Therapeutic development
5. Innovation
6. Feasibility (short-term results)

Supporting factors:
7. Future funding potential
8. Scientific rigor
9. Patient-centered outcomes

💡 Insider Insight

Compared to broader pulmonary or NIH funders:

The LAM Foundation is:
👉 ultra-niche (LAM only)
👉 translational + patient-impact focused
👉 strongly oriented toward rapid, actionable results

👉 Winning formula:
LAM-focused idea + treatment relevance + feasible pilot study + clear path to clinical impact

✔️ What wins:

New or repurposed therapies
Biomarkers or clinical trial–ready ideas
Patient-centered outcome research

❌ What struggles:

Non-LAM topics
Pure basic science without application
Long-term, unfocused projects

Specialties

Clinical Trials

Eligibility Requirements

• Allowable Principal Investigators (PIs) for all award mechanisms listed above:

o Qualified Applicants: MD, DO, PhD, DVM, or equivalent professional degree.

o Career Level: Postdoctoral researchers, postgraduate medical trainees, graduate students, junior faculty, and established investigators are all eligible.

o New Investigators: The Foundation encourages applications from investigators new to the field of LAM research who can offer fresh knowledge and expertise.

Sponsor Details

Sponsor Institute/Organizations: The LAM Foundation

Sponsor Type: Corporate/Non-Profit

Address: PO Box 42084 Cincinnati, OH 45242 Phone: (513) 777-6889 Email: info@thelamfoundation.org

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