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OutSmarting Osteosarcoma Young Investigator (YI) Hope Award

MIB Agents

The 2026 LOI submission period is now closed. Approved LOIs will be notified in early December and invited to submit a full application by January 25, 2026.

‍The OutSmarting Osteosarcoma Young Investigator (YI) Hope Award
$50,000 grant over one year to young investigators with a compelling study that will Make It Better for osteosarcoma patients.

Awards may be sponsored by one MIB Agents Family Fund or individual donor, which is co-branded in honor of the Family Fund. The number of grants by award type will be determined based on budget and program goals during programmatic review.

FUNDING PRIORITIES

To have the most immediate impact on patient care and outcomes, MIB Agents funding priorities are:

● Late-stage translational research - research may lead to clinical benefit or a clinical trial in less than five years.

● Studies with promising preclinical data that have a specific funding need to secure an IND and move forward to a clinical trial.

● Specific funding gaps in clinical research. Examples include correlative studies associated with and/or before an already funded clinical trial.

● Projects that facilitate and enhance collaboration and shared learnings.

AI Based Application Success Predictor

1. Absolute, Explicit Focus on Osteosarcoma

MIB Agents exclusively funds projects that directly improve outcomes for osteosarcoma patients.

High-priority topics include:

New therapeutic targets for osteosarcoma

Drug repurposing or combination strategies

Mechanisms of metastasis (especially lung metastasis)

Chemoresistance biology

Immunotherapy for osteosarcoma

Biomarkers or liquid biopsy

Better preclinical models (PDX, organoids, canine OS)

Novel radiology/imaging approaches

Survivorship, quality of life, and late toxicity in OS

❗ Generic sarcoma or bone cancer projects are not competitive unless they clearly center on osteosarcoma.

2. Fit With MIB Agents’ Grant Mechanisms

MIB Agents has several funding mechanisms with different expectations:

🔹 OutSmarting Osteosarcoma Grant (Flagship Award)

Early/mid-career investigators

Strong scientific rigor + translational potential

Must meaningfully address OS treatment, biology, or detection

High innovation strongly preferred

🔹 FACTORY Grants (Fast-Track, High-Impact)

Rapid, short-term projects

Emphasis on feasibility + clear deliverables

Often used for validating targets or methods quickly

🔹 Junior Investigator or Fellow Awards

Early-career focus

Strong mentorship required

🔹 Clinical/Translational Grants

Access to patients, tissue, trial infrastructure

Must have near-term clinical applicability

Predictor: Align your career stage, scope, and deliverables to the exact MIB mechanism.

3. High Translational Relevance

MIB Agents emphasizes applied research that will make a near-term difference.

Competitive proposals typically show:

Direct therapeutic development

Mechanistic discovery that leads to testable intervention

Biomarkers that can move into clinical settings

Strategies to reduce toxicity or improve quality of life

Work that accelerates drug development pipelines

Predictor: Proposals must clearly articulate how the project will improve survival or care for osteosarcoma patients.

4. Strong Preliminary Data

Even small or pilot grants usually require evidence of feasibility:

Early mechanistic data

Drug-response assays

Pilot biomarker results

Feasibility of obtaining samples

Early animal or in vitro model proof-of-concept

Predictor: Preliminary data is one of the strongest determinants of success.

5. Use of Osteosarcoma-Relevant Models

Highly successful proposals use validated osteosarcoma systems:

Patient-derived xenografts (PDX)

OS organoids or 3D culture

CRISPR or engineered OS cell line models

Canine osteosarcoma models (strongly valued due to translational relevance)

Lung metastasis models

Longitudinal imaging or ctDNA assays

Predictor: The use of state-of-the-art OS models greatly increases translational usefulness.

6. Collaboration & Data Sharing

MIB Agents strongly values collaborative science:

Multi-PI approaches

Clinician + basic scientist teams

Data sharing among OS groups

Partnerships with Children’s Oncology Group (COG), NCI, or other sarcoma consortia

Cross-institutional resource sharing

Predictor: Collaborative, synergistic proposals score significantly higher.

7. Patient-Centered Design

MIB Agents is a patient-driven organization, so proposals are strengthened by:

Clear relevance to patient outcomes (survival, QoL, toxicity reduction)

Inclusion of patient advocates where possible

Real-world justification for the proposed approach

Predictor: Projects that directly reflect patient needs have an advantage.

8. Strong Investigator Potential and Expertise

Reviewers look for:

Evidence of commitment to osteosarcoma research

Relevant publications in OS or bone/solid tumor models

Grantsmanship potential and clear research trajectory

Technical capability to carry out the project

Predictor: Investigator expertise in OS (or a compelling mentorship structure) increases reviewer confidence.

9. Clear, Focused, Milestone-Based Specific Aims

Successful proposals have:

2–3 well-defined aims

Measurable milestones

Realistic timelines

Clear go/no-go points

Strong contingency plans

Predictor: MIB Agents prioritizes feasibility + fast impact, so well-structured aims perform well.

10. Strong, Clean Writing and Visuals

Top-scoring grants are:

Exceptionally clear

Logically structured

Supported by strong visual preliminary data

Easy for both scientists and clinicians to understand

Predictor: High-quality communication significantly increases competitiveness.

🏆 Summary Table – MIB Agents Funding Predictors

Predictor	Why It Matters
Osteosarcoma-specific focus	Core requirement
Mechanism fit	Ensures proper expectations
Translational potential	MIB is impact-driven
Preliminary data	Demonstrates feasibility
Relevant OS models	Strengthens translational value
Collaboration	High priority for OS research
Patient-centered impact	Aligns with MIB’s mission
PI track record	Supports likelihood of success
Focused, feasible aims	Required for short-term grants
Strong writing & visuals	Improves reviewer enthusiasm

Specialties

Clinical Trials

Others

General Medicine

Eligibility Requirements

● At the time of the application due date (January 25, 2026), applicants must be within 5 years post-fellowship with experience in translational research.

● Academic rank may not exceed Assistant Professor

● M.D., D.O., D.V.M., and/or Ph.D. degrees may apply.

● At the time of application or successful award, the applicant must not hold an NIH independent (R or P) Award. Institutional training grants (K12, T32) are permitted.

● A research mentor must be identified. The application must document the mentor’s involvement in experimental design and execution and describe a career development and training plan.

Sponsor Details

Sponsor Institute/Organizations: MIB Agents

Sponsor Type: Corporate/Non-Profit

Address: P.O. Box 858, Barnard, VT 05031 518.524.3890 hello@MIBagents.org

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