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FACTOR Abstract Submission

MIB Agents

MIB Agents is a leading pediatric osteosarcoma nonprofit dedicated to making it better for our community of patients, families, medical professionals, researchers, and industry partners through programs, education, and research.

ABOUT FACTOR 2026 Started in 2017, the annual MIB Agents FACTOR conference brings together key stakeholders in the osteosarcoma community, including clinicians, researchers, industry, patients, families, patient advocates, and funders, to Make It Better for those battling this disease. FACTOR stands for Funding, Awareness, Collaboration, Trials, Osteosarcoma, and Research. In bringing the osteosarcoma community together, the goal is to drive collaboration on advancing treatments and improving outcomes for patients with osteosarcoma.

● Foster Collaboration: Facilitate connections among researchers, clinicians, surgeons, and patient families to enhance multidisciplinary collaboration in osteosarcoma research and treatment.

● Improve Patient Outcomes: Focus on strategies to enhance treatment effectiveness, reduce side effects, and improve the quality of life for patients living with osteosarcoma.

● Promote Research: Highlight cutting-edge research in osteosarcoma, with a focus on developing novel therapies, understanding disease mechanisms, and improving patient outcomes.

● Educate and Inform: Share the latest advances in osteosarcoma treatment and research with medical professionals, patients, and advocates to keep the community informed and engaged.

● Expand Clinical Trials: Encourage participation in and development of clinical trials to explore new treatments, improve existing therapies, and gather critical data for future innovations.

● Drive Funding and Awareness: Raise awareness about osteosarcoma and emphasize the need for increased funding to support ongoing research and clinical trials.

● Strengthen the Community: Build a stronger support network for patient families and survivors by providing a platform for sharing experiences, challenges, and successes.

SUBMISSION AND SELECTION PROCESS

Authors may submit abstracts for presentation at FACTOR 2026 on Proposal Central, beginning October 6, 2025. The abstract submission deadline is January 9, 2026. Abstracts will be considered for oral presentation or poster presentation at FACTOR 2026.

AI Based Application Success Predictor

1. Absolute, Explicit Focus on Osteosarcoma

MIB Agents exclusively funds projects that directly improve outcomes for osteosarcoma patients.

High-priority topics include:

New therapeutic targets for osteosarcoma

Drug repurposing or combination strategies

Mechanisms of metastasis (especially lung metastasis)

Chemoresistance biology

Immunotherapy for osteosarcoma

Biomarkers or liquid biopsy

Better preclinical models (PDX, organoids, canine OS)

Novel radiology/imaging approaches

Survivorship, quality of life, and late toxicity in OS

❗ Generic sarcoma or bone cancer projects are not competitive unless they clearly center on osteosarcoma.

2. Fit With MIB Agents’ Grant Mechanisms

MIB Agents has several funding mechanisms with different expectations:

🔹 OutSmarting Osteosarcoma Grant (Flagship Award)

Early/mid-career investigators

Strong scientific rigor + translational potential

Must meaningfully address OS treatment, biology, or detection

High innovation strongly preferred

🔹 FACTORY Grants (Fast-Track, High-Impact)

Rapid, short-term projects

Emphasis on feasibility + clear deliverables

Often used for validating targets or methods quickly

🔹 Junior Investigator or Fellow Awards

Early-career focus

Strong mentorship required

🔹 Clinical/Translational Grants

Access to patients, tissue, trial infrastructure

Must have near-term clinical applicability

Predictor: Align your career stage, scope, and deliverables to the exact MIB mechanism.

3. High Translational Relevance

MIB Agents emphasizes applied research that will make a near-term difference.

Competitive proposals typically show:

Direct therapeutic development

Mechanistic discovery that leads to testable intervention

Biomarkers that can move into clinical settings

Strategies to reduce toxicity or improve quality of life

Work that accelerates drug development pipelines

Predictor: Proposals must clearly articulate how the project will improve survival or care for osteosarcoma patients.

4. Strong Preliminary Data

Even small or pilot grants usually require evidence of feasibility:

Early mechanistic data

Drug-response assays

Pilot biomarker results

Feasibility of obtaining samples

Early animal or in vitro model proof-of-concept

Predictor: Preliminary data is one of the strongest determinants of success.

5. Use of Osteosarcoma-Relevant Models

Highly successful proposals use validated osteosarcoma systems:

Patient-derived xenografts (PDX)

OS organoids or 3D culture

CRISPR or engineered OS cell line models

Canine osteosarcoma models (strongly valued due to translational relevance)

Lung metastasis models

Longitudinal imaging or ctDNA assays

Predictor: The use of state-of-the-art OS models greatly increases translational usefulness.

6. Collaboration & Data Sharing

MIB Agents strongly values collaborative science:

Multi-PI approaches

Clinician + basic scientist teams

Data sharing among OS groups

Partnerships with Children’s Oncology Group (COG), NCI, or other sarcoma consortia

Cross-institutional resource sharing

Predictor: Collaborative, synergistic proposals score significantly higher.

7. Patient-Centered Design

MIB Agents is a patient-driven organization, so proposals are strengthened by:

Clear relevance to patient outcomes (survival, QoL, toxicity reduction)

Inclusion of patient advocates where possible

Real-world justification for the proposed approach

Predictor: Projects that directly reflect patient needs have an advantage.

8. Strong Investigator Potential and Expertise

Reviewers look for:

Evidence of commitment to osteosarcoma research

Relevant publications in OS or bone/solid tumor models

Grantsmanship potential and clear research trajectory

Technical capability to carry out the project

Predictor: Investigator expertise in OS (or a compelling mentorship structure) increases reviewer confidence.

9. Clear, Focused, Milestone-Based Specific Aims

Successful proposals have:

2–3 well-defined aims

Measurable milestones

Realistic timelines

Clear go/no-go points

Strong contingency plans

Predictor: MIB Agents prioritizes feasibility + fast impact, so well-structured aims perform well.

10. Strong, Clean Writing and Visuals

Top-scoring grants are:

Exceptionally clear

Logically structured

Supported by strong visual preliminary data

Easy for both scientists and clinicians to understand

Predictor: High-quality communication significantly increases competitiveness.

🏆 Summary Table – MIB Agents Funding Predictors

Predictor	Why It Matters
Osteosarcoma-specific focus	Core requirement
Mechanism fit	Ensures proper expectations
Translational potential	MIB is impact-driven
Preliminary data	Demonstrates feasibility
Relevant OS models	Strengthens translational value
Collaboration	High priority for OS research
Patient-centered impact	Aligns with MIB’s mission
PI track record	Supports likelihood of success
Focused, feasible aims	Required for short-term grants
Strong writing & visuals	Improves reviewer enthusiasm

Specialties

Clinical Trials

Oncology

Others

General Medicine

Orthopedics

Regenerative Medicine

Eligibility Requirements

● Individuals may submit up to 2 abstracts as the first author.

● Presenting authors must be registered FACTOR 2026 participants. Submitting an abstract for presentation at FACTOR 2026 does not constitute registration for the meeting.

● If selected for oral presentation at FACTOR 2026, authors will receive a promotional code to use during conference registration. This promotional code will cover conference registration fees.

● If their institutions will not cover accommodation costs, oral and poster presenters may apply for a Family Fund FACTOR Travel Award.

● An abstract can be submitted if it was/will be presented at a scientific meeting in the past year. If it was presented prior to 2025, then it cannot be submitted unless there is significant new data.

Sponsor Details

Sponsor Institute/Organizations: MIB Agents

Sponsor Type: Corporate/Non-Profit

Address: P.O. Box 858, Barnard, VT

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