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New Investigator Grant

National Scleroderma Foundation

Purpose:

The National Scleroderma Foundation seeks applications from promising new investigators who hold faculty or equivalent positions and who wish to pursue a career in research related to scleroderma. This grant supports promising research that is likely to lead to individual research project grants.

Terms of Award:

The New Investigator Award is a three-year award in the amount of $200,000 total. Applicants may request up to $66,667 per year (this amount is to include budgeted indirect costs) for up to three years, with the total award not to exceed $200,000. A maximum of 8% of the proposed yearly budget may be allocated to indirect costs. These awards are not renewable. Before completion of this grant, investigators are encouraged to seek continuing support for research through other grant mechanisms through private or government agencies. Replacement of the principal investigator on this award is not permitted. There will be no routine escalation for future years.

Awards are contingent on the availability of funds and the receipt of sufficiently meritorious applications meeting the stated eligibility requirements.

Research Objectives:

The New Investigator Grant is designed to facilitate the entry of promising new investigators into areas of research related to scleroderma.

Applications for the FY27 cycle are now open. The deadline to submit applications is September 15, 2026.

AI Based Application Success Predictor

1. Direct relevance to scleroderma research (highest predictor)

This is the most important review criterion.

Competitive proposals focus directly on:

Systemic sclerosis (scleroderma)
Fibrosis mechanisms
Autoimmunity
Vasculopathy
Interstitial lung disease (ILD)
Pediatric scleroderma
Biomarker discovery
Disease pathogenesis
Novel therapeutic approaches

The Foundation funds investigator-directed projects, but they must have clear relevance to scleroderma.

2. Innovation and scientific significance (very high predictor)

For Established Investigator Grants, the Foundation explicitly seeks highly innovative and/or highly relevant pilot studies.

Competitive applications typically include:

Novel biological hypotheses
Innovative therapeutic strategies
New biomarkers
Advanced molecular or immunologic approaches
Cutting-edge translational research

Projects that substantially advance understanding or treatment of scleroderma are prioritized.

3. Strong potential to improve patient outcomes (very high predictor)

The Foundation's mission is to discover the cause of scleroderma, understand its mechanisms, and ultimately overcome the disease.

Strong proposals demonstrate potential to:

Improve diagnosis
Develop new therapies
Prevent organ damage
Improve survival
Reduce fibrosis
Improve quality of life

Projects with a realistic pathway toward clinical benefit receive strong consideration.

4. Pilot data with potential for future major funding

One of the clearest published priorities is supporting research that can lead to larger grants.

The Foundation states that:

New Investigator Grants should help launch independent research careers.
Established Investigator Grants should support pilot projects likely to lead to substantial federal or private funding (e.g., NIH, DoD, VA).

5. Strong early-career investigator potential (New Investigator Grants)

The New Investigator Grant is specifically intended for promising faculty beginning independent careers.

Competitive applicants generally demonstrate:

Strong research potential
Commitment to scleroderma research
Career independence
Long-term research plans

Applicants are expected to have completed postdoctoral training but not previously served as principal investigators on major external research grants.

6. Rigorous scientific design and feasibility

Applications undergo peer review by an international committee of scleroderma experts.

Competitive proposals include:

Clear hypotheses
Strong methodology
Appropriate statistical analysis
Realistic milestones
Feasible timelines
Well-justified budgets

Scientific rigor is central to the Foundation's NIH-style peer-review process.

7. Investigator expertise and research environment

Successful applicants generally demonstrate:

Expertise in rheumatology
Immunology
Fibrosis biology
Pulmonology
Vascular biology
Translational medicine

A strong institutional environment and access to appropriate laboratory or clinical resources strengthen applications.

8. Focus on priority clinical areas

Although investigator-directed proposals are accepted, the Foundation has identified priority areas such as:

Scleroderma-associated interstitial lung disease
Pediatric scleroderma
Fibrosis biology
Immune dysregulation
Organ involvement

Projects addressing these high-priority areas may be particularly competitive when such initiatives are announced.

9. Peer-review excellence and scientific merit

The Foundation's grants are reviewed by an international Peer Research Review Committee using a rigorous merit-based evaluation process similar to NIH review.

Applications are assessed for:

Scientific quality
Innovation
Significance
Feasibility
Investigator qualifications

Only the highest-ranked proposals receive funding.

Specialties

Dermatology

Eligibility Requirements

Applications may be submitted by domestic non-profit organizations, public and private such as universities, colleges, hospitals, and laboratories. Foreign organizations and institutions are not eligible. These new investigator grants may not be used to support thesis or dissertation research or fellowship training. Applicants must have a doctoral degree in Medicine, Osteopathy, Veterinary Medicine or one of the sciences; and must have completed a postdoctoral fellowship by the grant award date. Applicants who have been a principal investigator on grants from the National Scleroderma Foundation or other national, private or government agencies other than fellowship grants are not eligible for this award.

Investigators who have questions about eligibility should contact the National Scleroderma Foundation at resesearch@scleroderma.org for more information.

Eligible Countries:

United States

Sponsor Details

Sponsor Institute/Organizations: National Scleroderma Foundation

Sponsor Type: Corporate/Non-Profit

Address: 55 Ferncroft Road Suite #315 Danvers, MA 01923

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