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International Scholar Awards

St. Baldrick's Foundation

The St. Baldrick's Foundation is a volunteer and donor powered charity committed to supporting the most promising research to find cures for childhood cancers and give survivors long and healthy lives.

It started with a friendly dare: would you shave your head to raise money for kids’ cancer research? What happened next would change the world. This bold act of baldness has gained major momentum, since its start in 2000. Today, we have more than 1,000 head-shaving events taking place around the world at pubs, restaurants, schools, churches, parks, firehouses, military bases – you name it. It is our constituents’ way of changing the world, in a meaningful way. Volunteers also raise funds through athletic challenges, livestream fundraisers and many other activities.

Since the Foundation's first grants as an independent charity in 2005, St. Baldrick's has invested more than $368 million in childhood cancer research grants worldwide. It’s about collaboration. It’s about powerful ideas, big and small. It’s about never giving up until we have cures for all kids with cancers.

FUNDING HIGHLIGHTS

The St. Baldrick’s Foundation works hard to be sure that every dollar makes the biggest impact possible in childhood cancer research. The Foundation is proud to have received the National Cancer Institute Peer Review Funder designation for selection of grants. The Foundation has held several Research Priorities Summits with many of the country’s leading pediatric oncology researchers participating to advise the staff and board of directors on funding priorities. The St. Baldrick’s team and scientific advisors meet regularly to be sure St. Baldrick’s funds make the greatest impact on pediatric cancer research.

Current funding priorities are divided into four categories:

• New discovery research

• Translational research and early phase clinical trials

• Phase III clinical trials & infrastructure support of participating institutions (primarily the fall grant cycle)

• Education of new pediatric oncology researchers

In addition to research to understand the biology of childhood cancers and discover leads to more effective treatments, topics of interest include, but are not limited to:

• Adolescents & young adults

• Survivorship, outcomes, and quality of life

• Supportive care

• Epidemiology and pediatric cancer predispositions

• Precision medicine

• Alternative & complementary therapies

AI Based Application Success Predictor

1. Clear, Direct Focus on Childhood Cancer

The top predictor is that the project specifically benefits pediatric/AYA cancer patients, including:

Leukemias (ALL, AML)

Brain & CNS tumors (medulloblastoma, glioma, DIPG/DMG)

Neuroblastoma

Sarcomas (osteosarcoma, Ewing, RMS)

Lymphoma

Rare pediatric malignancies (histiocytic disorders, germ cell tumors)

High-priority themes:

Relapsed/refractory disease

Drug resistance mechanisms

Targeted and immunotherapies

Minimal residual disease detection

Novel biomarkers

Treatment toxicity reduction & survivorship

Neurocognitive, endocrine, psychosocial outcomes

❗ Adult oncology projects with children as a subpopulation do not score well.

2. Mechanism Alignment With Career Stage & Project Scope

Perfect match matters:

Mechanism	Best For	Critical Criteria
St. Baldrick’s Fellows	Pediatric oncology trainees	Mentorship + training environment
Early Career / Scholar Awards	Junior faculty	Trajectory → independent funding
Translational/Consortium	Established investigators & multi-site teams	Patient access + clinical impact
Supportive Care Grants	Clinicians & outcomes researchers	QoL, toxicity mitigation, disparities

Predictor: Fit PI career stage, project maturity, and patient access to the exact call.

3. Strong Preliminary Data

Even pilot grants show:

Feasibility proven in models or early trials

Early biomarker signals

Evidence that required assays, recruitment, and collaborations are established

Target expression or mechanistic rationale validated in pediatric tumors

Predictor: Feasibility and strong rationale → major scoring factor.

4. Pediatric-Relevant Models and Patient Access

Winning proposals leverage:

Patient-derived xenografts (PDX) from children

Pediatric tumor cell lines or organoids

Multi-omics data from pediatric tumors

Access to biobanks, Children’s Oncology Group (COG), pediatric trial groups

Defined cohort recruitment strategy for clinical studies

Predictor: Authentic pediatric relevance is essential.

5. Translational or Clinical Trial Pathway

St. Baldrick’s wants to change outcomes, not only understand disease.

Funded proposals show:

Clear route to trials within 3–5 years

IND-enabling milestones if drug-focused

Biomarker validation toward clinical utility

Defined endpoints to prove patient benefit

Predictor: Promising pathway to clinical impact increases enthusiasm.

6. Strong Investigator Track Record

Reviewers reward:

Publications in pediatric oncology

Prior success in grant delivery

Unique expertise aligned to the project

Clear development into a leader in childhood cancer research

Predictor: PI quality is heavily weighted, especially for Scholar/Faculty awards.

7. Excellence in Mentorship & Environment (for Trainees/Early-Career)

Critical criteria:

Well-funded primary mentor with pediatric oncology leadership

Protected time for research

Robust institutional infrastructure (cores, patients, imaging, GMP if needed)

Co-mentors for complementary skillsets

Predictor: Mentor strength influences reviewer confidence.

8. Well-Defined, Milestone-Based Aims

Best proposals include:

2–3 hypothesis-driven aims

Rapid, measurable milestones

Clear go/no-go decisions

Realistic for 1–3 year timelines

Plan for future funding (NIH/DOD/COG)

Predictor: Feasibility & clarity are top scoring criteria.

9. High Innovation & Urgency

St. Baldrick’s seeks transformative solutions:

First-in-field mechanistic insights

Novel cell/gene therapies

Combination regimens addressing resistance

Real-world solutions to survivorship harms

Cross-disciplinary technologies

Predictor: Innovation + urgent clinical need = reviewer enthusiasm.

10. Clear, Convincing Writing

Winning proposals are:

Logically structured

Supported by visual preliminary data

Strong in rigor & methodology

Accessible to both clinicians and laboratory reviewers

Compliant with guidelines & page limits

Predictor: Clean writing often separates top-tier applications.

🏆 Summary — St. Baldrick’s Foundation Success Predictors

Predictor	Why It Matters
Pediatric cancer focus	Core mission
Mechanism alignment	Correct evaluation
Preliminary data	Feasibility validation
Pediatric models	Clinical relevance
Translational path	Near-term patient benefit
PI trajectory	Investment return
Mentorship & environment	Execution & independence
Feasible aims	Deliverable results
Innovation	Big impact potential
Strong writing	Higher reviewer scoring

Specialties

Pediatrics

Eligibility Requirements

This three (3) year award, with an option for two (2) additional years based on progress, is to train researchers from low- and middle- income countries (as classified by the World Bank) to prepare them to fill specific stated needs in an area of childhood cancer research upon returning to their country of origin. Proposals should detail a realistic impact of the award on pediatric cancer research in their country of origin. Recipients are called St. Baldrick’s International Scholars. Grants will be up to $110,000/year, for three years.

• The research proposal must include 2–3 years of training at the sponsoring institution, as well as the implementation of a carefully constructed research project at the institution of origin (see below).

• Selection criteria will include the scientific merit of the research proposal, scientific quality and impact of proposed training, the potential for the Scholar to continue training other investigators in their country of origin, and the commitment of the scholar’s institution of origin to develop and continue the research program in order to increase the chances of long-term success. See below for full review criteria.

• International Scholar are one of many funding categories offered by the St. Baldrick’s Foundation; it is possible for a program/institution to receive funding in more than one category. With the exception noted immediately below, each program/institution may submit one (1) LOI/application in all open St. Baldrick’s funding categories

Sponsor Details

Sponsor Institute/Organizations: St. Baldrick's Foundation

Sponsor Type: Corporate/Non-Profit

Address: 1333 South Mayflower Avenue, Suite 400 Monrovia, CA 91016 USA (888) 899‑2253 · sbinfo@stbaldricks.org

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