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Healthy After Cancer: Childhood Cancer Survivorship Award

Children's Cancer Research Fund

This award is intended to shape the future of cancer survivorship treatment and care. We invite applications that focus on improving the quality and quantity of life for childhood, adolescent, and young adult cancer survivors. Our goal is to support development of interventions that prevent, minimize, and address the late effects of cancer therapies.

Proposals to develop drugs or modalities meant to mitigate late effects, as the sole or primary focus, are eligible. Proposals to develop therapeutic approaches (new drugs, modalities, or regimens for treating cancer) are not eligible to apply. In addition, projects that propose to translate basic research into interventions, regardless of whether these take place during active therapy or later, are encouraged. Observational studies are welcome but are a lower priority, except those describing late effects (or early signs of late effects) among children receiving novel agents or therapies.

Award Information

Application Types

We will accept applications that are new or from a previous pilot study. We will also accept applications (R03, R21) that have been reviewed but not funded by the National Institutes of Health (NIH). We will also consider proposals that were awarded, but later cancelled, by the NIH as long as they correspond to the requirements of this funding mechanism. (See Resubmission of NIH Funded Applications below for additional information).

Number of Awards

Funding of awards will be dependent on the availability of funds.

Award Period

Maximum project period is 24 months.

Award Budget

A budget for total costs up to $125,000 per year may be requested. This includes indirect costs of up to 10% of direct costs.

Clarifications:

• Allowable direct costs include salaries, fringe benefits, supplies, sub-contracts, publication costs, equipment & travel expenses.

• CCRF adheres to the NIH salary cap for Principal Investigators.

• Project-related travel is allowed as needed and must be fully justified. Up to $2,000 per year for conference travel.

• All sub-contracts and collaborations must be described and well-justified.

• If utilizing a subcontract, the PI’s institution is responsible for disbursing subcontract funds.

• Any equipment to be purchased with grant funds must be well-justified.

• Indirect costs of 10% of direct costs are allowed.

AI Based Application Success Predictor

Although CCRF does not publish formal predictors, its guidelines and review practices reveal clear, consistent factors that strongly influence success:

✔ 1. Alignment with CCRF Priority Areas (CRITICAL)

Must directly address:

hard-to-treat cancers

survivorship

disparities

👉 Strongest predictor:
perfect thematic alignment with CCRF focus areas

✔ 2. Translational & Clinical Impact

Preference for research that:

improves outcomes

leads to new treatments or interventions

impacts patient care

👉 CCRF prioritizes real-world applicability

✔ 3. Innovation & “Seed Funding” Potential

CCRF often funds:

pilot or feasibility studies

high-risk, early-stage ideas

👉 Strong predictor:
projects that can lead to larger NIH/foundation grants later

✔ 4. Scientific Merit & Study Design

Clear:

hypotheses

methods

evaluation metrics

👉 High-quality methodology is essential for peer review

✔ 5. Feasibility & Scope

Projects must be:

achievable within budget/time

realistic and well-planned

👉 Especially important for pilot-scale funding

✔ 6. Patient-Centered Impact

Strong preference for:

improving quality of life

addressing survivorship issues

reducing disparities

👉 Especially critical for:

survivorship and disparities awards

✔ 7. Equity & Disparities Focus

CCRF explicitly prioritizes:

underserved populations

modifiable inequities

👉 Projects proposing solutions (not just descriptions) are favored

✔ 8. Investigator Capability & Track Record

Competitive applications show:

relevant expertise

preliminary data or prior work

publication history

👉 Even early-career investigators benefit from demonstrated capacity

✔ 9. Institutional & Collaborative Strength

Strong proposals include:

institutional support letters

multidisciplinary teams

👉 Collaboration improves feasibility and impact

✔ 10. Strong LOI (Hidden Gatekeeper)

Only top LOIs are invited to submit full proposals

👉 LOI quality is a major early predictor of success

📌 What Is NOT Publicly Available

CCRF does not publish:

numerical scoring systems

success rates

predictive probability models

🧾 Key Insight

👉 CCRF is a strategic, translational seed funder in pediatric oncology.

Practical “Success Formula”

Strong CCRF grant =

Priority alignment + translational impact + innovation + feasibility + patient relevance

📌 Summary

The Children’s Cancer Research Fund (CCRF) funds competitive pediatric cancer research grants focused on high-impact areas.

It uses a peer-reviewed LOI → full proposal process with expert committees.

While no formal success predictors are published, funding decisions are strongly driven by:

alignment with priority areas

translational and patient impact

innovation and feasibility

scientific rigor

investigator and institutional strength

Specialties

Cancer

Pediatrics

Eligibility Requirements

• Applicants must be eligible to serve as a Principal Investigator at their sponsoring institution.

• Applicant institutions must be based in the United States.

• Applicants are not required to be United States citizens.

• Awarded PIs are required to commit at least 10 percent of their research efforts each year to activities supported by this award.

• Submission of a Letter of Intent (LOI) is required.

• Co-Investigators and/or collaborators are permitted, but the award must be made to a single institution which will act as the grant administrator.

• Applicants’ organizations may submit more than one application, provided each application is scientifically distinct. However, CCRF will only accept one LOI from a PI each calendar year.

• Applicants should review all necessary materials and use the appropriate templates and forms. Failure to comply with the instructions provided may result in programmatic or administrative rejection of your Letter of Intent (LOI) or full application.

Sponsor Details

Sponsor Institute/Organizations: Children's Cancer Research Fund

Sponsor Type: Corporate/Non-Profit

Address: 1650 W 82nd St., Suite 400 Minneapolis, MN 55431

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