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CTSI Open Call for Concept Proposals -- Limited Competition: NCATS Clinical and Translational Science Award (CTSA) Program Research Education Grant (R25 Clinical Trial Not Allowed)

Duke University

The Clinical and Translational Science Institute (CTSI) serves as the administrative hub for Duke’s Clinical and Translational Science Award (CTSA), supporting the development, implementation, and dissemination of innovative solutions to accelerate the translation of scientific discoveries into improved healthcare. As a CTSA Hub, Duke University is eligible to apply for the Limited Competition: NCATS CTSA Program Research Education Grants Programs (R25 — Clinical Trial Not Allowed) (PAR-25-197) .

The overarching goal of this R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nation’s biomedical, behavioral, and clinical research needs. Specifically, R25-supported research experiences are expected to be relevant to NCATS’ mission of studying translation on a system-wide level, agnostic to a specific disease, to better understand the scientific and operational principles underlying each step of the translational process. The goal is not to focus on specific diseases, but on what is common among them and the translational science process.

CTSI leadership is supporting the submission of one R25 application from Duke and is inviting brief, 3-page R25 concept proposals from eligible Duke faculty. Submitted concepts (due September 1, 2026) will be reviewed internally and one applicant will be selected to prepare a full proposal for NIH submission by the May 28, 2027, deadline.

Internal Concept Submission Deadline: September 1, 2026

Specialties

Medical

Medical - Translational

Medical - Clinical Science

Eligibility Requirements

Eligibility for R25 PI and team include the following:

PI Appointment: The Principal Investigator (PI) must hold an appointment and be affiliated with Duke University and be eligible to serve as a PI on NIH grants according to the written policy of the PI’s home institution.
PI Qualification (NIH Requirement): Per PAR-25-197, the PD/PI must be an established investigator who has successfully competed for an R01 or R01-equivalent grant in the targeted scientific area. The PD/PI must be capable of providing both administrative and scientific leadership to the program.
UM1 Constraint: The Duke CTSA UM1 PD(s)/PI(s) may NOT serve as PD(s)/PI(s) on the R25 application, per PAR-25-197 requirements.
Research Team Expertise: The research team must demonstrate expertise and experience relevant to the proposed program, including mentoring and teaching experience in clinical and translational science.

Collaborations across Duke, NCCU Durham Tech, or with other CTSA hubs and community organizations, are strongly encouraged. Applicants interested in developing collaborations with NCCU are encouraged to contact the Duke-NCCU Bridge Office .

Sponsor Details

Sponsor Institute/Organizations: Duke University

Sponsor Type:

Address: 103 Allen Bldg, Durham, NC 27708

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