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NOIP: Elucidation and Validation of the role of Transporters in the Placenta, Lactating Mammary Gland, Developing Gut, and Blood Brain Barrier

National Institutes of Health

Note: This is a Forecasted Opportunity.

The Eunice Kennedy Shriver National Institute of Child Health and Human Development seeks to advance its mission of supporting maternal, fetal, and child health by continuing to enhance the understanding of maternal, fetal, and child exposure to nutrients, metabolites, medications, supplements, microbiome-derived products, and environmental chemicals. This will be done by supporting a second phase of the Transporter Elucidation Network (TEN). This phase of the TEN will establish perinatal multi-barrier transport network frameworks to clarify how transporters and local biotransformation regulate these processes. Building on prior organ-focused models, methods, and datasets, this initiative will develop standards, resources, models, and prototype multi-compartment approaches spanning maternal gut, placenta, lactating mammary epithelium, infant gut, and infant blood-brain barrier. The initiative is expected to support a mechanistic understanding of transporter function, polarity, kinetics, and transformation capacity relevant to pregnancy, lactation, infant nutrition, pediatric pharmacology, and neurodevelopment. By emphasizing multi-barrier perinatal transporter frameworks this phase of the TEN will provide community resources for future integrated studies of perinatal exposure, risk, and intervention across interlinked maternal, fetal, and infant systems. It will also strengthen coordination among investigators, accelerate dissemination of tools, and advance human-based, developmentally relevant transporter research and workforce development.

Estimated Post Date:

Jul 24, 2027

Estimated Application Due Date:

Oct 20, 2027

Specialties

Medical

Medical - Clinical Science

Medical - Basic Science

Medical - Translational

Eligibility Requirements

Sponsor Details

Sponsor Institute/Organizations: National Institutes of Health

Sponsor Type: Government/Federal

Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA

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