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Clinical Research Investigator-Initiated Awards

Crohn's & Colitis Foundation

To directly impact patient care by addressing an important clinical question by studying people either through direct interaction with the people and/or indirectly by studying people through large databases, such as claims data or administrative data. Therefore, the expectation is that the research findings from funded CRIAs will result in highly-cited publications, citations in clinical guidelines, and/or follow-on funding to advance the research further.

Priority will be given to proposals that address the priorities outlined in the Pragmatic Clinical Research publication within the Challenges in IBD Research, and how the results would impact prevailing practice in this area. There needs to be a compelling clinical rationale to justify a focus outside of these priority areas.

adlines
Pre-Application	Deadline: December 2, 2025 11:59pm EST
Full Proposal (via Invitation)	January 22, 2026 11:59pm EST
Applications Review	April – May
Decisions Announced	June

Grant Funding Terms: The maximum budget request: $250,000/year in total costs (10% IDC maximum allowed), for three years. The Foundation will no longer accept requests from applicants to exceed this budgetary threshold. The total budget can be requested for up to three years. Specific milestones will be agreed upon as part of the funding process, and continued funding is dependent on achieving these milestones, which will be reviewed scientifically and administratively.

AI Based Application Success Predictor

Strong IBD Focus

Research must directly address Crohn’s disease or ulcerative colitis, aligned with CCF’s “Challenges in IBD Research” strategic roadmap.

Independent & Appropriate Career Stage

Student Fellowships for undergrad/grad/medical students with faculty mentorship .

Postdoctoral Fellowships for early post-PhD/MD researchers showing the need for training .

Career Development Awards target promising mid-stage investigators poised for independence .

Senior Research Awards support established investigators to build pilot data for major funding like NIH 

Mentorship & Institutional Support

Fellowships require a formal mentoring plan and student awards require a non-relative faculty mentor 

Senior and career awardees must be fully independent and affiliated with eligible institutions (non-profit/public/government) .

Competitive Funding & Budget Compliance

Budgets vary by award:

Student: up to $2.5K 

Fellowship: up to $70K/year 

Senior: up to $130K/year with direct and capped indirect costs .

Funding cycles typically follow LOI → full proposal stages with strict submission through proposalCENTRAL or Flexigrant .

Strategic Alignment & Innovation Focus

Proposals should address high-impact questions outlined in the foundation’s Challenges in IBD report, such as precision medicine, environmental triggers, novel technologies, and translational or pragmatic clinical research .

Access to Resources & Data

Senior awardees can leverage IBD Plexus biosamples and datasets to boost data quality and justification .

Rigorous Peer Review & Reporting

Applications are reviewed by panels of scientists, clinicians, and people with IBD

Funded grants require annual progress reports and long-term impact tracking (via Researchfish®).

Publications must acknowledge Foundation support and inventions reported.

📝 Summary Table

Award Category	Success Factors
Student Fellowship	Direct IBD relevance; strong mentor; full-time commitment.
Postdoctoral Fellowship	Focused training in IBD; mentor plan; legal work status in U.S.
Career Development	Mid-career readiness; mentor support; address career gaps.
Senior Research Award	Established independence; IBD-focus; institutional support; IBD Plexus integration.

🚀 Tips to Strengthen Your Application

Align with IBD Challenges report—situate your proposal within CCF priority areas.

Choose the right award—match your career stage and independence level.

Secure mentor & institutional backing early—include commitment letters.

Plan your budget carefully—follow limits and institutional roles.

Utilize CCF resources—like IBD Plexus sample/data for senior-level applicants .

Craft a compelling LOI to earn an invitation to the full proposal.

Prepare for reporting expectations—progress reports, publications, impact data tracking.

Specialties

Gastroenterology

Eligibility Requirements

PI and Co-PI must be employed by institutions (public non-profit, private non-profit, or government) engaged in health care and/or health related research. International applicants are also eligible to apply, and there are no geographical restrictions regarding research site locations.

Senior Research Award (CRIA-SRA): The lead PI must be a faculty member (minimum Assistant Professor level) with a successful track record of funded clinical research projects and relevant expertise in the clinical question to be addressed. There must be a research team that includes at least one junior Co-PI (Instructor or Assistant Professor, prior to receiving an independent RO1 grant or international equivalent) with experience in IBD research, who is committed to IBD research as a part of his or her career development.
Career Development Award (CRIA-CDA): *The Foundation is sensitive to personal matters that impact career trajectories. Applicants who have taken leave from their career (e.g., parenting of a child, childbirth, long-term care of a parent/spouse/child/dependent, personal health issues), or have been impacted by the COVID-19 pandemic in a way that puts them outside of the eligibility time frame, should feel free to reach out to Foundation staff ahead of their application submission. We aim to be flexible and adjust these time frames if necessary and appropriate. This can be captured in the applicant's cover letter.* The lead PI must be a junior faculty member (Instructor or Assistant Professor, prior to receiving an independent R01 grant or international equivalent) with experience in IBD research, who is committed to IBD research as a part of his or her career development. Generally, junior PI candidates should not be more than ten years beyond the attainment of their doctoral degree at the time of application.

Proposal Eligibility: Proposed study matches the scope of the program, as described in the RFP, and eligibility criteria are met. Only one proposal may be submitted per submission date. Applicants for a CRIA-CDA may not simultaneously apply or be included in an application for a CRIA-SRA. CRIA-CDA and CRIA-SRA applications will compete for the same funding. Applicants for a CRIA may not simultaneously submit another application on the same research topic for a Litwin IBD Pioneer award, Clinical Research Network Award or Research Initiative. Successful applicants may not hold concurrent Crohn’s & Colitis Foundation CDAs or SRAs; however, applications for new projects may be submitted 6 months prior to the termination of the awardee’s current grant.

Sponsor Details

Sponsor Institute/Organizations: Crohn's & Colitis Foundation

Sponsor Type: Corporate/Non-Profit

Address: 733 THIRD AVENUE, SUITE 510, NEW YORK, NY 10017

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