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Clinical Research Grants

Dravet Syndrome Foundation

Clinical Research Grants are intended for established, experienced, independent investigators affiliated with a research or academic institution whose proposed projects have a clinical focus and investigate hypotheses directly related to Dravet syndrome. Proposals are scored according to NIH guidelines based on the quality of preliminary data, research design, feasibility, investigator’s qualifications, and overall impact. Grants are awarded for $250,000 over 2 years (beginning January 1 of each year), with indirect costs not to exceed 10% of the award.

Investigators applying for a research grant should ensure their proposed project addresses the needs of the Dravet syndrome community and DSF’s mission to support research toward better treatments and a cure for Dravet syndrome.

DSF Clinical Priority Areas include:

Research that helps better characterize the natural history of Dravet syndrome across the patient lifetime, including identifying patient trends, characteristics, epidemiology, or other clinical aspects of Dravet syndrome and/or its comorbidities
Research that develops or refines outcome measurements that can fully reflect meaningful improvements in patient symptoms and quality of life
Research that helps to understand, predict, and prevent SUDEP
Research that will encourage the development of novel therapies to prevent onset or halt the progression of the Dravet syndrome

AI Based Application Success Predictor

🧠 1. Focus on Dravet Syndrome or SCN1A-Related Research

Prior research directly involving:

SCN1A mutations, sodium channel dysfunction, or genetic epilepsy models.

Animal or cellular models of Dravet syndrome.

Clinical studies involving Dravet patients (e.g., biomarkers, seizure monitoring, natural history studies).

👩‍🔬 2. Demonstrated Expertise in Epilepsy or Neuroscience

Strong background in neurology, neurogenetics, ion channel physiology, or pharmacology.

Publications in relevant journals (e.g., Epilepsia, Brain, Neurobiology of Disease).

Prior experience with preclinical or translational epilepsy research.

🧬 3. Innovative and Disease-Relevant Proposals

Projects that explore novel therapeutic strategies, including:

Gene therapy (e.g., AAV, ASOs)

Precision medicine approaches

Disease-modifying or seizure-suppressing treatments

Emphasis on bench-to-bedside potential and alignment with DSF’s mission to improve outcomes for Dravet patients.

👩‍🔧 4. Feasibility and Preliminary Data

Early-stage proof-of-concept data showing rationale for the project.

Clear research design and timeline.

Feasibility of completing aims within 1–2 years.

🧑‍🔬 5. Early-Career and Independent Investigators

DSF supports both established and early-career researchers.

For early-career awards: demonstrated promise, strong mentorship, and institutional backing are essential.

🤝 6. Collaborative and Translational Orientation

Multidisciplinary projects combining basic science, clinical insight, and therapeutic development.

Partnerships between academia and industry or cross-institutional collaborations.

🏛 7. Institutional Affiliation

Strong research institution or medical center with epilepsy/neuroscience expertise.

Access to relevant infrastructure: animal facilities, EEG monitoring, sequencing platforms, patient cohorts.

🎓 DSF Grant Mechanisms:

Research Grant Awards – up to $200,000 over 2 years.

Postdoctoral Fellowships

Clinical & Preclinical Research Grants

Gene Therapy Research Grants (in partnership with other organizations)

Infrastructure or data-sharing initiatives (e.g., biobank support, patient registries)

Specialties

Clinical Trials

Neurosciences

Eligibility Requirements

Applicants should be affiliated with a research or academic institution (excluding for-profit companies), may be US or foreign based, established in their field, and in good standing with their institution.

Sponsor Details

Sponsor Institute/Organizations: Dravet Syndrome Foundation

Sponsor Type: Corporate/Non-Profit

Address: PO Box 3026, Cherry Hill, NJ 08034

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