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CARRA-Arthritis Foundation Advancing Biosample Collection Award

Childhood Arthritis and Rheumatology Research Alliance (CARRA)

This funding opportunity supports biosample collection within the CARRA network to advance CARRA translational research. The goal is to collect biosamples from patients enrolled in the CARRA Registry, to be used by CARRA investigators for future hypothesis-based research. This mechanism funds the collection of biosamples at CARRA Registry sites utilizing the CARRA Registry biosample consent form. Priority will be given to funded projects.

2 Awards

$50,000 per award

LOI Deadline: January 20, 2026

Application Deadline: March 2, 2026

AI Based Application Success Predictor

When reviewers evaluate CARRA applications, they tend to look for:

✔ 1. Direct Relevance to Pediatric Rheumatic Disease

Applications must address a specific clinical or translational question in diseases such as juvenile idiopathic arthritis, pediatric lupus, dermatomyositis, scleroderma, or vasculitides — ideally leveraging CARRA’s registry or biorepository. CARRA

✔ 2. Use of CARRA Registry or Collaborative Infrastructure

Projects that use existing registry data or biosamples (e.g., for comparative effectiveness research) often score well because they align with CARRA’s mission to generate real-world evidence. CARRA

✔ 3. Clear, Feasible Research Plan

A well-scoped design with realistic methods and defined milestones boosts competitiveness, especially for pilot and small grant applications. CARRA

✔ 4. Investigator Qualifications & Mentorship

For career development awards, evidence of preparation (publications, training) and strong mentorship are crucial predictors of success. Research at UCalgary

✔ 5. Collaborative and Multidisciplinary Approach

Grants that involve multiple investigators or disciplines — particularly those that show how team science will yield deeper insights — are viewed favorably. CARRA

✔ 6. Potential to Generate Preliminary Data for Larger Grants

Projects that intend to seed future NIH, PCORI, or foundation funding are attractive since they amplify CARRA’s strategic impact. Arthritis Foundation

🛠 Practical Application Tips

✔ Align aims with CARRA’s mission to improve outcomes for children with rheumatic diseases. CARRA
✔ Integrate registry data when possible to strengthen feasibility and impact. CARRA
✔ Define clear deliverables (e.g., data analysis plans, consensus tools, pilot safety/efficacy measures). CARRA
✔ Engage collaborators early — multicenter participation resonates with CARRA’s collaborative ethos. CARRA
✔ Highlight career relevance for mentored awards, with strong letters from mentors. Research at UCalgary
✔ Budget realistically for the scope and period of the award. CARRA

📌 Summary: CARRA Competitive Funding

Award Type	Target	Focus	Typical Support
Mentored Career Development Award	Early independent investigators	Career phenotype in pediatric rheumatology	~$375,000 (3 yrs) Rheumatology Research Foundation
Fellows Grant	Trainee researchers	Project support during fellowship	~$25,000 (1 yr) Rheumatology Research Foundation
Small Grant	Investigators	Pilot or focused research	~$50,000 (1 yr) Rheumatology Research Foundation
Clinical Management JIA Grant	Clinician scientists	Registry-based decision research	~$100,000 (2 yrs) Rheumatology Research Foundation
Advancing Biosample Collection	Translational research	Biorepository expansion	~$50,000 (2 yrs) Rheumatology Research Foundation
Team Science / Large Grants	Collaborative teams	Planning or larger cross-center work	~$100,000+ (2 yrs) Rheumatology Research Foundation
Travel Awards	Early investigators	Conference presentations	~$2,000 Rheumatology Research Foundation
CARRA-PReS Collaborative Award	Early career international	Collaborative pilot work	~€50,000 (2 yrs)

Specialties

Rheumatology

Eligibility Requirements

• The project principal investigator (PI) must be a CARRA member in good standing (up to date on membership dues and member profile is current and accurate).

• The PI must have served as a PI or co-investigator (co-I) on a research study that has successfully requested CARRA Registry data, completed the research, and published results.

• Applicants must hold an advanced degree (MD or equivalent, PhD, or MD/PhD) and must have a faculty or equivalent government appointment.

• All applications must be submitted by or include a pediatric rheumatologist named as a co-I).

• The project PI or co-PI must be a member of the CARRA Registry network.

• While not eligible to serve as PIs, the following may serve as team members: medical and graduate students, research professional members who are regulatory or data coordinators, business and industry associate members, and nonprofit/government associate members.

• CARRA board members or those in executive leadership positions may not serve as study leadership.

• Previous and current CARRA awardees who wish to submit new grant applications must be up to date on all award deliverables.

• All sites proposing to collect samples under this grant mechanism must be current, active CARRA Registry sites. Participating site investigators must also be listed authorized personnel on the current CARRA Registry delegation of authority log, managed by DCRI.

Sponsor Details

Sponsor Institute/Organizations: Childhood Arthritis and Rheumatology Research Alliance (CARRA)

Sponsor Type: Corporate/Non-Profit

Address: 1050 Connecticut Avenue, NW, Suite 500 Washington, DC 20036

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