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Career Development Awards

Breakthrough T1D

Brief Description Designed to attract qualified and promising scientists early in their faculty careers and to give them the opportunity to establish themselves in areas that reflect the Breakthrough T1D research emphasis areas

Proposal Access and submit full applications (including research plans) via RMS360.

Terms 200,000 USD maximum/year for up to 5 years, including up to 10% for indirect costs and generally not renewable after 5 years

Description Breakthrough T1D fosters the development and productivity of the best and the brightest established independent researchers who will bridge the gap between the bench and bedside. The primary purpose of the Career Development Award is to attract qualified and promising scientists early in their faculty careers and to give them the opportunity to establish themselves in areas that reflect the Breakthrough T1D research emphasis areas.

In the five-year term of the award, awardees will focus their research efforts on a subject directly related to Breakthrough T1D mission goals and Breakthrough T1D Research Strategy, and position themselves to work at the leading edge of type 1 diabetes research. These awards are designed to assist exceptionally promising investigators. Although Breakthrough T1D is especially interested in fostering careers in clinical investigation, Career Development Awards may emphasize either basic or clinical topics.

Terms of the Award The award is up to USD 200,000 per year, including indirect costs. These funds may be used for a research allowance, which can include a technician, supplies, equipment and travel up to USD 2,000 per year. The awards are renewable pending satisfactory progress up to a maximum of four years.

AI Based Application Success Predictor

1. Strong alignment with Breakthrough T1D strategic priorities (highest predictor)

This is the single most important predictor.

Breakthrough T1D prioritizes research in areas such as:

Disease-modifying therapies
Prevention of T1D
Beta-cell replacement and regeneration
Immune tolerance and immunotherapy
Screening and early detection
Diabetes technology (CGM, automated insulin delivery)
Complication prevention
Precision medicine approaches
Cell therapies

Projects that clearly fit current strategic funding priorities are substantially more competitive than investigator-driven projects with only indirect relevance.

2. Clear path toward improving outcomes for people with T1D (very high predictor)

Breakthrough T1D is highly mission-driven.

Competitive proposals typically demonstrate potential to:

Delay or prevent T1D onset
Preserve beta-cell function
Improve glycemic control
Reduce disease burden
Improve quality of life
Prevent complications
Move toward a functional cure

Reviewers often place strong emphasis on translational impact and patient benefit.

3. Translational potential and milestone-driven development (very high predictor)

Compared with many traditional research funders, Breakthrough T1D places exceptional emphasis on translation.

Successful applications often include:

Clearly defined milestones
Product-development pathways
Regulatory considerations
Commercialization strategies when relevant
Go/no-go decision points

Projects that can advance toward clinical testing or implementation frequently receive favorable consideration.

4. Strong scientific rationale and mechanistic foundation

Even highly translational proposals must demonstrate:

Strong biological rationale
Sound preliminary evidence
Mechanistic understanding
Robust study design
Appropriate statistical planning

Breakthrough T1D supports innovation, but projects must be scientifically credible and well supported.

5. Investigative team expertise and multidisciplinary collaboration

Many funded projects involve collaborations among:

Immunologists
Endocrinologists
Beta-cell biologists
Bioengineers
Computational scientists
Clinical trialists
Industry partners

Strong multidisciplinary teams are often viewed favorably, especially for complex translational projects.

6. Preliminary data and feasibility

Although some exploratory programs support early-stage ideas, most competitive applications include:

Preliminary data
Proof-of-concept evidence
Feasibility studies
Pilot results

Reviewers want confidence that proposed milestones can realistically be achieved.

7. Potential to attract follow-on investment or larger funding

Breakthrough T1D frequently acts as a catalyst for:

NIH funding
Industry partnerships
Venture investment
Advanced translational development

Projects likely to generate future funding opportunities often receive positive consideration.

8. Patient-centered relevance and community impact

A distinctive feature of Breakthrough T1D is its close engagement with the T1D community.

Strong projects often consider:

Patient priorities
Real-world usability
Treatment burden
Accessibility
Health equity
Long-term quality-of-life outcomes

Research that addresses meaningful patient needs tends to resonate strongly with reviewers.

9. Innovation and potential for transformative impact

Breakthrough T1D is willing to support ambitious science when the potential payoff is substantial.

Competitive projects frequently involve:

Novel immunotherapies
Advanced cell therapies
Gene-editing approaches
AI-driven diabetes management
New biomarkers
Transformative disease-modifying strategies

Innovation alone is not sufficient, but highly innovative projects with strong feasibility are particularly attractive.

Specialties

Endocrinology and Diabetes

Eligibility Requirements

Institutional Eligibility

Domestic & foreign non-profit organizations; public & private universities, colleges, hospitals, laboratories; units of state & local governments; eligible agencies of the federal government

Applicant Eligibility Required: MD, DMD, DVM, DO, PsyD, PhD, or equivalent and faculty position or equivalent

The Career Development Award is intended for individuals at an early stage of their independent academic career. Researchers who have received their first faculty-level appointment less than 3 years before the submission date are eligible to apply for this award. The applicant must hold an academic faculty-level position (including assistant professor or equivalent) at the time of submission of the proposal, at a university, health science center, or comparable institution with strong, well-established research and training programs for the chosen area of interest.

Breakthrough T1D is sensitive to personal and COVID-related matters that impact career trajectories. Applicants who have taken leave from their career (e.g. parenting of a child, childbirth, long-term care of a parent/spouse/child/dependent, personal health issues) or experienced a delay due to COVID shutdowns that puts them outside of the eligibility time frame for the award mechanism should reach out to Breakthrough T1D staff ahead of their application submission. Breakthrough T1D aims to be flexible and adjust these time frames if necessary and appropriate.

Career Development Award research may be conducted at foreign and domestic, for-profit and nonprofit, and public and private organizations – such as universities, colleges, hospitals, laboratories, units of state and local governments, and eligible agencies of the federal government.

Sponsor Details

Sponsor Institute/Organizations: Breakthrough T1D

Sponsor Type: Corporate/Non-Profit

Address: 200 Vesey Street, 28th Floor, New York, NY 10281

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