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Bio-Therapeutics Impact Grant

Alex's Lemonade Stand Foundation

The ALSF Bio-Therapeutics Impact Award provides funding to support investigator-initiated clinical trials using biologic therapies, including but not limited to immunotherapy (including cell therapies), gene therapy, and small molecules. This grant category was initiated to accelerate the development of clinical trials for promising biologic approaches to treat childhood cancers.

ALSF’s Travel For Care program is available to patients enrolled in the clinical trial supported by this award. A medical representative must apply on behalf of the families who meet our criteria as listed in the Travel For Care guidelines. The online request form must specify that the clinical trial is funded by ALSF’s Bio-Therapeutics Impact Award.

Application Timeline and Review

• A full proposal must be submitted that meets all guideline criteria as well as all eligibility criteria; otherwise, applications will be administratively rejected.

• Full proposals will be reviewed by an independent panel of experts according to the NIH recognized peer-review process, overseen by the Bio-TherapeuticsImpact Grant Scientific Review Board.

• The date for Finalist Presentations is listed below. If invited, applicants are expected to work to be available at this time.

APPLICATION TIMELINE FULL PROPOSAL DUE June 9, 2026, 8PM EST

FINAL PRESENTATIONS (VIRTUAL) October 20, 2026, 12-4PM EST

AWARD NOTIFICATION November 2026

PROJECTED START December 2026

AI Based Application Success Predictor

🧒 1. Strong Focus on Pediatric Cancer (Non-Negotiable)

Proposals must directly address:
- Childhood cancers (not adult oncology)
Priority areas:
- High-risk, relapsed, or rare pediatric cancers

👉 ALSF funds projects that fill critical gaps in pediatric oncology

🔬 2. High Scientific Excellence (Top Predictor)

Grants are selected via rigorous peer review (NIH-style)
Key evaluation factors:
- Scientific significance
- Innovation
- Impact

👉 Funding is awarded primarily based on peer-review ranking and quality of science

🚀 3. Innovation & Novel Ideas (Critical)

ALSF strongly favors:
- New, original, and high-risk ideas
Especially projects:
- Not yet funded elsewhere
- Lacking preliminary data but highly promising

👉 Foundation explicitly supports early-stage, innovative concepts

🔄 4. Translational Potential (Bench → Bedside)

Strong preference for:
- Research that can move toward clinical application
Example:
- Reach Grants aim to push research toward clinical trials

👉 Projects must show a clear path to patient benefit

🎯 5. Addressing Unmet Clinical Needs

Successful proposals:

Target cancers with:
- Poor outcomes
- Limited treatment options
Aim to:
- Develop new therapies
- Improve survival or reduce toxicity

👉 “Unmet need” is a major decision factor

👩‍🔬 6. Investigator Potential & Career Development

ALSF strongly invests in researchers:

Early-career:

Commitment to pediatric oncology
Strong mentorship + career plan

Senior investigators:

Track record + leadership

👉 Many grants are designed to build future pediatric cancer leaders

🧪 7. Feasible, Well-Designed Study

Clear:
- Hypothesis
- Methodology
- Timeline
Realistic scope aligned with funding

👉 Feasibility is essential due to competitive funding environment

🤝 8. Collaboration & Multidisciplinary Teams

Strong proposals often include:
- Multi-institution collaborations
- Cross-disciplinary expertise

👉 Large initiatives (e.g., “Crazy 8”) emphasize team science

📊 9. Potential for High Impact & Future Funding

ALSF evaluates whether research will:
- Lead to larger grants (NIH, etc.)
- Produce meaningful scientific or clinical advances

👉 ALSF acts as seed + accelerator funding

🌐 10. Resource Sharing & Broader Impact

Applicants must include:
- Plans to share data, tools, or reagents
Emphasis on:
- Advancing the broader research community

📊 Summary: Key Predictors (Ranked)

Highest impact factors:

Pediatric cancer focus
Scientific excellence
Innovation

Moderate predictors:
4. Translational potential
5. Addressing unmet clinical needs
6. Investigator potential

Supporting factors:
7. Feasibility
8. Collaboration
9. Future funding potential

💡 Insider Insight

Compared to other pediatric cancer funders:

Alex's Lemonade Stand Foundation is:
👉 innovation-driven + gap-filling

👉 Key success question:
“Is this a bold, high-quality idea that could lead to a cure for childhood cancer—and isn’t already funded elsewhere?”

High-risk ideas ✔️
Pediatric focus ✔️
Clear path to impact ✔️
→ Highest success probability

Specialties

Cancer

Oncology

Clinical Trials

Pediatrics

Eligibility Requirements

• Applicant institutions must be based in the United States or Canada. Applicants need not be United States citizens. Funds must be granted to nonprofit institutions or organizations.

• Applicants must have an MD, PhD, or MD/PhD (or equivalent) and be appointed to the level of Assistant Professor or higher.

• Study team has completed pre-clinical studies informing the trial and holds an approved IND.

• Demonstrates a track record of implementing and executing biologics clinical trials through publishing a prior investigator-initiated clinical trial as a lead PI or as a member of a study committee.

• Applicants working within a consortium are eligible. See restrictions below related to networks with established per-patient reimbursement mechanisms already in place.

Sponsor Details

Sponsor Institute/Organizations: Alex's Lemonade Stand Foundation

Sponsor Type: Corporate/Non-Profit

Address: 333 E. Lancaster Ave, #414, Wynnewood, PA 19096

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