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Applying for the Mathers Grant Awards Program
The Mathers Grant application process involves several key steps, each requiring specific information and documentation to meet the Foundation’s requirements. If approved, grants are typically awarded within five to six months of LOI submission. All program-related activities must be managed through the portal.
Grant Timeline & Due Dates
Grant schedules and submission deadlines are fixed annually.
No exceptions will be made for late submissions.
| Cycle | Institutional Nominations and Portal Registration | LOI Application | Invited Formal Proposals |
|---|---|---|---|
| Spring 2025 | Feb 28th, 2025 8pm EST | Mar 14th, 2025 8pm EST | May 23rd, 2025 8pm EST |
| Fall 2025 | Sep 19th, 2025 8pm EST | Oct 3rd, 2025 8pm EST | Dec 12th, 2025 8pm EST |
AI Based Application Success Predictor
The G. Harold & Leila Y. Mathers Foundation, established in 1983 in Santa Barbara, California, honors the philanthropic legacy of G. Harold Mathers and Leila Young Mathers. Their vision emphasized supporting basic medical research and scholarships. Over time, the Foundation has grown into a permanently endowed, independent philanthropic entity, dedicated to funding innovative basic science with translational promise.Headquartered in Rye Brook, New York, it is guided by a dedicated board of trustees.
What Makes Mathers Grants Predictors of Success
1. High-Impact, High-Risk Funding
The Foundation targets bold, high-risk/high-reward basic science that’s usually not yet competitive for federal funding. The focus spans fields like immunology, microbiome research, structural biology, cellular physiology, cancer biology, genomics, infectious diseases, stem cell biology, and neuroscience. Clinical trials, drug discovery, COVID-19, plant biology, and environmental studies are explicitly excluded.
2. Generous and Programmatic Support
Grant size: Up to $600,000–$700,000 over three years, inclusive of a maximum 10% for indirect costs.
Eligible applicants: Independent PIs with their own, fully equipped labs at U.S.-based 501(c)(3) institutions.
Limited Submissions: Institutions can nominate up to three LOIs per cycle, with cycles in Spring (e.g., LOI due ~March 14, proposal due ~May 23, 2025) and Fall (e.g., LOI ~October 3, proposal ~December 12, 2025).
Strategic Funding Pathway: Acts as seed funding, helping investigators produce preliminary data essential for pursuing larger federal grants.
Why Mathers Funding Signals Future Success
Selectivity & Prestige: Few recipients—at all career stages—receive such substantial, flexible support, making awardees stand out in the research community.
Encourages Innovation: Emphasizes novel, foundational discovery with translational potential, especially for projects not yet competitive for traditional grant mechanisms.
Cross-Institutional Impact: Recognized across institutions like Harvard, Stony Brook, USC, UCI, and Penn State, often generating internal competitions and broad institutional support.
Career Milestones: Securing a Mathers grant often signals a PI is ready to launch high-impact, independent research—making it a notable career inflection point.
Summary Table
| Aspect | Details |
|---|---|
| Foundation Focus | Basic life sciences with translational potential |
| Excluded Research Areas | COVID-19, plant biology, environmental studies, clinical trials, drug discovery |
| Grant Value | $600K–$700K over 3 years (≤10% IDC) |
| Applicant Eligibility | U.S.-based independent PIs with fully equipped labs |
| Cycle Structure | Spring & Fall; institutions limited to 3 LOIs per cycle |
| Success Predictor Traits | Supports novel, high-impact projects outside federal funding pathways |
Bottom line: The Mathers Foundation is a powerful predictor of future success in biomedical research. Awards are a signal of innovation, institutional trust, and potential for transformative science.
Specialties
Eligibility Requirements
Medical research universities and scientific institutions that are 501(c)(3) organizations are eligible to apply. Please note that we do not provide advice on project ideas or specific areas of interest.
Eligible for Funding
- Institutions that directly support their own investigators
- Principal Investigators with their own fully equipped labs
- All levels of professorship
- Collaborative research projects with other U.S.-based organizations
Ineligible for Funding
- Institutions based outside the United States
- Institutions that do not employ their own investigators
- Private Foundations or third-party organizations that provide funding to other organizations
- Grants to individuals
Eligible Countries:
Sponsor Details
Sponsor Institute/Organizations: Mathers (G.Harold and Leila Y.) Foundation
Sponsor Type: Corporate/Non-Profit
Address: 800 Westchester Avenue Suite N-503 Rye Brook, New York 10573
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Grant
Letter Of Intent Deadline:
Dec 12, 2025
Final Deadline:
Dec 12, 2025
Funding Amount:
$700,000
Host Details
Affiliation: Mathers (G.Harold and Leila Y.) Foundation
Address: 800 Westchester Avenue Suite N-503 Rye Brook, New York 10573
Website URL: https://mathersfoundation.org/how-to-apply/
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