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Alzheimer’s Association Health Services Research in Alzheimer’s Disease and Related Disorders (HSR-ADRD) Funding Program

Alzheimer's Association

The HSR-ADRD program seeks to support research that strengthens dementia detection, diagnosis, and post-diagnostic care pathways along the care continuum. Projects may address a range of health services research questions, including, but not limited to, studies examining barriers and solutions to timely access, quality, and care coordination. By supporting rigorous and innovative research, this program aims to generate actionable evidence to improve person-centered, coordinated, and equitable brain health and dementia care.

Program overview

The program welcomes proposals that utilize rigorous methodologies to advance understanding and improvement of cognitive impairment, including MCI and Alzheimer’s disease and related dementias (AD/ADRD) detection, diagnosis, and post-diagnostic care.

This award is structured as an individual research grant, with funding administered through the recipient’s institution. Proposals should address one or more Areas of Focus. Areas of Focus represent high-priority research topics for which this program is actively seeking proposals and include:

The Value of Early Detection and Diagnosis: Studies should investigate outcomes associated with early detection and diagnosis on at least two levels of the dementia care ecosystem (i.e., individual/families, providers/clinicians, health systems/payers, and policy/society).
Care Pathways for Individuals with MCI or Dementia: Studies should consider comorbidities and investigate how people are being screened and diagnosed in different settings, and the post-diagnosis pathways for care and treatment, including pharmacological and non-pharmacological interventions or combinations thereof.

Key dates and deadlines

Letter of Intent due: May 6, 2026 – 5 p.m. ET
Full application due: July 22, 2026 – 5 p.m. ET
Award notifications: by Nov. 30, 2026

Funding overview

Each HSR-ADRD award is limited to a total of $250,000 U.S. (direct and indirect costs) for a duration of up to two years (awards should be a minimum one year).
Indirect costs are capped at 10 percent of total direct costs and are inclusive of indirect costs for the implementing institution as well as for any subcontracts.
Detailed guidelines on allowed costs are included in the RFA.

Application process

Letters of intent are required. More information can be found in the RFA and on ProposalCentral.
Full applications must be submitted through ProposalCentral.

Application review process

Please see “how to apply” for more information about the Alzheimer’s Association application review process. Details are also available in the RFA.

Additional information

For more information on eligibility, application requirements, review criteria, and more, please see the RFA.
All applicants/institutions are strongly encouraged to review the Conditions of Award (PDF) before submitting an LOI.

AI Based Application Success Predictor

🧠 1. Strong Focus on Alzheimer’s Disease & Related Dementias (Non-Negotiable)

Projects must directly address:
- Alzheimer’s disease (AD) or:
- Alzheimer’s disease and related dementias (ADRD)
Includes:
- Diagnosis
- Prevention
- Treatment
- Care and quality of life

👉 Non-dementia neuroscience → low success probability

🔄 2. Strong Translational Pathway (Top Predictor)

The Association funds:
- Basic science → translational → clinical → care research
Increasing emphasis on:
- Translational research and clinical interventions

👉 Key question:
“How will this improve diagnosis, prevention, treatment, or patient care?”

🎯 3. Clear Clinical or Patient Impact (Critical)

Successful proposals usually:

Improve:
- Early diagnosis
- Therapeutic strategies
- Dementia care
- Prevention approaches

👉 Patient benefit is a major scoring factor

🚀 4. Innovation & High-Risk, High-Reward Science

The Alzheimer’s Association actively funds:
- Novel and breakthrough ideas
Especially through:
- Part the Cloud (PTC) initiatives for translational trials

👉 Incremental proposals are less competitive

🧬 5. High Priority Areas: Biomarkers, Early Detection & Therapeutics

Frequently funded areas:

Blood-based biomarkers
Neuroimaging
Precision medicine
Disease-modifying therapies
Early prediction models

👉 Early detection and therapeutic development are especially competitive

👩‍🔬 6. Early-Career Investigator Development (Major Priority)

The Association strongly supports:
- Postdocs
- Junior faculty
- New investigators entering dementia research

👉 Career development potential is heavily weighted

🤝 7. Strong Mentorship & Research Environment

Fellowship and early-career awards require:
- Structured mentorship
- Institutional support
Strong mentors improve competitiveness substantially

🌍 8. Broad Research Scope Including Care & Health Equity

Unlike some neurodegeneration funders, the Alzheimer’s Association funds:

Social-behavioral research
Care interventions
Public health and prevention
Health equity studies

👉 Community and caregiving research can be highly competitive if impactful

🧪 9. Feasible, Well-Designed Pilot Research

Many awards are:
- Pilot or career-development grants
Strong proposals include:
- Clear aims
- Realistic timelines
- Preliminary rationale

👉 Overly ambitious projects are commonly rejected

📈 10. Potential for Future NIH or Major Funding

Alzheimer’s Association grants are often:
- Seed funding mechanisms
Strong proposals:
- Generate pilot data for:
  - NIH R01s
  - Clinical trials
  - Large consortium grants

🌐 11. International & Collaborative Research Advantage

The program is:
- International in scope
Encourages:
- Cross-institutional and multidisciplinary collaboration

👉 Collaboration strengthens competitiveness, especially for translational projects

📊 Summary: Key Predictors (Ranked)

🔥 Highest impact factors:

Alzheimer’s/ADRD-specific focus
Translational relevance
Clear patient or clinical impact

⚖️ Major differentiators:

Innovation/high-risk ideas
Biomarker or therapeutic relevance
Early-career investigator development

📌 Supporting factors:

Mentorship quality
Feasibility
Future funding potential
Collaboration

💡 Insider Insight

Compared to NIH:

Alzheimer's Association is:
👉 more willing to fund:
- Early-stage ideas
- Pilot studies
- High-risk concepts
Strongly focused on:
- Career development
- Translational impact

👉 Winning formula:
Innovative AD-focused project + translational pathway + strong mentorship + feasible pilot design

✔️ What wins:

Biomarker and early detection studies
Translational therapeutic research
Innovative pilot projects with clinical potential
Care and health equity interventions with measurable impact

❌ What struggles:

Non-AD neuroscience
Pure basic science without translational relevance
Weak clinical significance
Overly broad or unrealistic proposals

Specialties

Neurosciences

Eligibility Requirements

Applicants can be any career level, including postdoctoral fellow but must hold a full-time position at the time of the grant application submission at an academic institution, or Veterans Administration hospital in the U.S.
International applicants are welcome.
Individuals currently enrolled as a student in an undergraduate, master or doctoral program are not eligible, regardless of prior degree status.
Applicants CANNOT submit more than one proposal to any of the programs in the current grant competition—even if the proposals cover distinctly different topics (i.e. only one application is allowed regardless of the distinct areas of focus).
Full eligibility criteria are detailed in the RFA.

Sponsor Details

Sponsor Institute/Organizations: Alzheimer's Association

Sponsor Type: Corporate/Non-Profit

Address: 225 N Michigan Ave. Floor 17 Chicago, IL 60601 800.272.3900

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