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Peer Reviewed Alzheimer’s Research - Investigator-Initiated Research Award

Department of Defense(DOD)

Program Description

Applications to the Fiscal Year 2022 (FY22) Peer Reviewed Alzheimer’s Research Program (PRARP) are being solicited by the U.S. Army Medical Research Acquisition Activity (USAMRAA) using delegated authority provided by United States Code, Title 10, Section 4001 (10 USC 4001). The execution management agent for this program announcement is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC). The PRARP was initiated in FY11 to address the long-term consequences of traumatic brain injury (TBI) as they pertain to Alzheimer’s disease (AD) and AD-related dementias (ADRD). Appropriations for the PRARP from FY11 through FY21 totaled $153 million (M). The FY22 appropriation is $15M.

The PRARP prioritizes research that will provide meaningful outcomes to support caregivers and persons with AD and ADRD, with a focus on partnership with those most impacted by these conditions. In addition, the PRARP strongly advocates for study population diversity, including but not limited to ethnic, cultural, socioeconomic, and health access factors.

In addition to a focus on individual and care support, the PRARP seeks to support research focusing on the intersection of TBI-AD/ADRD, including understanding mechanisms, biomarkers, and risk factors associated with Veteran populations. The PRARP is interested in supporting research leading to treatment modalities that have near-term benefit.

The proposed research must be relevant to active-duty Service Members, Veterans, military beneficiaries, and/or the American public.

Specialties

Cardiovascular Diseases

Genetics & Genomics

Eligibility Requirements

Eligible Applicants

Organization: All organizations, including foreign organizations, foreign public entities, and international organizations, are eligible to apply.

Government Agencies Within the United States: Local, state, and federal government agencies are eligible to the extent that applications do not overlap with their fully funded internal programs. Such agencies are required to explain how their applications do not overlap with their internal programs.

As applications for this program announcement may be submitted by extramural and intramural organizations, these terms are defined below.

Extramural Organization: An eligible non-DOD organization. Examples of extramural organizations include academic institutions, biotechnology companies, foundations, federal government organizations other than the DOD, and research institutes.

Intramural DOD Organization: A DOD laboratory, DOD military treatment facility, and/or DOD activity embedded within a civilian medical center. Intramural Submission: An application submitted by a DOD organization for an intramural investigator working within a DOD laboratory or military treatment facility or in a DOD activity embedded within a civilian medical center.

The USAMRAA makes awards to eligible organizations, not to individuals.

Principal Investigator

Independent investigators at all academic levels (or equivalent) may be named by the organization as the PI on the application.

Early-Career Investigator Partnering PI Option

The Early-Career Investigator must be an independent investigator within 10 years of their terminal degree by the time of the application submission deadline (excluding time spent in residency or on family medical leave) or new to the field. Investigators new to the field will have nominal, if any, publications or funding support in either TBI or AD/ADRD. Time spent as a postdoctoral fellow is not excluded. Lapses in research time or appointments as denoted in the biographical sketch should be explained in the application.

An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by, or affiliated with, an eligible organization.

The CDMRP strongly encourages all PIs to participate in a digital identifier initiative through Open Researcher and Contributor ID, Inc. (ORCID). Registration for a unique ORCID identifier can be done online at https://orcid.org/.

Cost Sharing

Cost sharing/matching is not an eligibility requirement.

Other

Organizations must be able to access .gov and .mil websites in order to fulfill the financial and technical deliverable requirements of the award and submit invoices for payment.

Eligible Countries:

Sponsor Details

Sponsor Institute/Organizations: Department of Defense(DOD)

Sponsor Type:

Address: 1400 Defense Pentagon; Washington, DC 20301-1400;United States

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