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Military Burn Research Program - Technology/Therapeutic Development Award

Department of Defense(DOD)

Program Description

Applications to the Fiscal Year 2022 (FY22) Military Burn Research Program (MBRP) are being solicited by the U.S. Army Medical Research Acquisition Activity (USAMRAA) using delegated authority provided by United States Code, Title 10, Section 4001 (10 USC 4001). The execution management agent for this program announcement is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC). The MBRP was initiated in 2011 to address combat-related and trauma-induced burn injuries as well as to improve health and performance outcomes for Service Members and the general public. Appropriations for the MBRP from FY11 through FY21 totaled $90 million (M). The FY22 appropriation is $10M.

The proposed research must be relevant to active-duty Service Members, Veterans, military beneficiaries, and/or the American public. '

Burn injuries sustained by military Service Members while in the line of duty, whether on the battlefield, or in a military training environment, represent a continuous health burden on both the injured Service Member and the Department of Defense health care systems in which they receive care. Historically, burn injuries afflicted some 5% to 20% of casualties during postWorld War II conflicts.1 In recent years, burns sustained during Operation Iraqi Freedom/Operation Enduring Freedom affected nearly 9% of combat-related casualties. 2 While thermal burns represent the most common mechanism of burn injury, atypical burns such as frostbite, high-voltage electrical, chemical, directed energy, and nuclear represent additional formidable threats to the health and well-being of Service Members. The Armed Forces Health Surveillance Division reports an increased number of cold related injuries in recent years; highvoltage accidents occur on and off the battlefield; and the threat of chemical, nuclear, or directed energy weapons is an ever-present danger. Regardless of mechanism, combat-associated burn injuries are devastating due, in part, to the high incidence of concurrent severe traumatic injuries. In addition, burns sustained in a deployed environment more often lead to severe burns than those sustained in the civilian setting. The majority of combat burns in recent conflicts resulted from explosive device detonation, leading to a greater Injury Severity Score, an increase in inhalation injuries, and a larger, full-thickness burn size.3 It is anticipated that in future conflicts the explosive weaponry used against U.S. forces will be more powerful than that seen in the past, likely resulting in a higher number of casualties with significant injuries and larger, more severe burns. Irrespective of the injury mechanism, assessment and treatment of burn wounds at or close to the point-of-injury remains a challenge to medical and non-medical first responders alike. The time is long past for the burn care community to develop, refine, or test novel therapies or technologies that would allow for better provision of care and improved patient outcomes.

Specialties

Emergency Medicine

Eligibility Requirements

Eligible Applicants

Organization: All organizations, including foreign organizations, foreign public entities, and international organizations, are eligible to apply.

Government Agencies Within the United States: Local, state, and federal government agencies are eligible to the extent that applications do not overlap with their fully funded internal programs. Such agencies are required to explain how their applications do not overlap with their internal programs.

As applications for this program announcement may be submitted by extramural and intramural organizations, these terms are defined below.

Extramural Organization: An eligible non-DOD organization. Examples of extramural organizations include academic institutions, biotechnology companies, foundations, federal government organizations other than the DOD, and research institutes.

Intramural DOD Organization: A DOD laboratory, DOD military treatment facility, and/or DOD activity embedded within a civilian medical center. Intramural Submission: An application submitted by a DOD organization for an intramural investigator working within a DOD laboratory or military treatment facility or in a DOD activity embedded within a civilian medical center.

The USAMRAA makes awards to eligible organizations, not to individuals.

Principal Investigator

PIs at or above the level of Assistant Professor (or equivalent) may be named by the organization as the PI on the application.

There are no limitations on the number of applications for which an investigator may be named as a PI.

An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by, or affiliated with, an eligible organization.

The CDMRP strongly encourages all PIs to participate in a digital identifier initiative through Open Researcher and Contributor ID, Inc. (ORCID). Registration for a unique ORCID identifier can be done online at https://orcid.org/.

Cost Sharing

Cost sharing/matching is not an eligibility requirement.

Other

Organizations must be able to access .gov and .mil websites in order to fulfill the financial and technical deliverable requirements of the award and submit invoices for payment.

Eligible Countries:

Sponsor Details

Sponsor Institute/Organizations: Department of Defense(DOD)

Sponsor Type:

Address: 1400 Defense Pentagon; Washington, DC 20301-1400;United States

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