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Young Investigator in Alex's Lemonade Stand Foundation

Alex's Lemonade Stand Foundation

The Young Investigator grant is a three-year award designed to support early career researchers, such as postdoctoral fellows, clinical fellows or instructors, pursuing promising childhood cancer research ideas. These grants aim to cultivate the best and brightest researchers of the future who demonstrate a commitment to a research career in pediatric cancer. A mentor is required, and a career development plan must be included. The Young Investigator grant offers up to $60,000 in direct costs per year for three years.

AI Based Application Success Predictor

1. 🎯 Strong Alignment with ALSF’s Mission & Research Focus

ALSF funds research specifically in childhood cancer — proposals must clearly focus on cancers in children (not adult cancers), and especially on novel approaches, new therapies, or filling critical gaps in pediatric oncology. alexslemonade.org+2alexslemonade.org+2

Projects should aim toward less toxic treatments, improved survivorship, or therapies for cancers that are currently hard to treat. alexslemonade.org+1

2. 🧑‍🔬 Appropriate Career Stage & Grant Program

ALSF offers different award types depending on career stage: e.g., the “A” Award (up to ~US $800,000/4 years) for early faculty establishing independence. Research at UCalgary+1

They expect applicants to have a clear commitment to pediatric cancer research — for example, you should demonstrate that this field will be your long-term focus. Research at UCalgary+1

3. 📚 Innovation, Novelty & Feasibility

ALSF explicitly states that they want projects that are original and not currently being funded. For example, the “A” Award guidelines say: “original project that is not currently being funded.” Research at UCalgary

Feasibility matters: strong scientific rationale, well-designed research plan, realistic budget, and milestones.

4. 🏫 Institutional Support & Protected Research Time

For major awards (e.g., “A” Award), applicants must allocate a large percentage of their time (e.g., ≥ 75%) to research activities during the grant period. Research at UCalgary

Institutional commitment (department chairs, division chiefs) and letters of support strengthen applications.

5. 🔄 Resource Sharing & Broader Impact

ALSF requires applicants to include a Resource Sharing Plan: if you generate unique reagents, data, or tools, you must describe how those will be shared. Research at UCalgary

They value the long-term impact of the research — e.g., whether it can lead to trials, new therapies, or make a meaningful difference in childhood cancer outcomes. alexslemonade.org+1

6. 🤝 Collaboration & Big Picture Thinking

Some ALSF initiative programs (e.g., the “Crazy 8 Initiative”) fund large, multi-investigator, multi-institution teams tackling the most difficult childhood cancers. These projects are collaborative, high-risk/high-reward. alexslemonade.org+1

Even for smaller grants, showing connections, cross-discipline thinking, or potential for follow-on funding is beneficial.

📋 Summary Table of Success Predictors

Success Predictor	Why It Matters for ALSF Applications
Clear focus on childhood cancer	Funders only consider pediatric cancers (not adult cancers)
Appropriate award match (career stage, scope)	Ensures you fit the eligibility and expectations of the award
Novel, not-currently-funded project idea	Demonstrates uniqueness and ability to fill a gap
Strong scientific design, feasibility & milestones	Shows you can execute and deliver meaningful results
Institutional backing & protected time	Funders want to know you have support and time to succeed
Resource-sharing plan and broader impact	Amplifies value of investment and aligns with ALSF ethos
Collaboration or long-term translational potential	Strengthens potential for major impact and follow-on opportunities

Specialties

Cancer

Oncology

Eligibility Requirements

At the time of application
•
Applicant institutions must be based in the United States or Canada. Applicants need not be United States citizens. Funds must be granted to nonprofit institutions or organizations.
•
Applicants must have an MD, PhD, or MD/PhD or equivalent and must not have achieved an appointment higher than Instructor. Assistant Professors, including adjuncts at this level, will not be considered. In addition:
o
Applicants from accredited clinical fellowship programs are automatically eligible for the duration of their training and during their first three years at the Instructor level.
o
Applicants not from accredited clinical fellowship programs must meet the following criteria:
▪
Applicants holding an MD or MD/PhD must be within seven years from the granting of the last doctoral degree at the time of application.
▪
Applicants holding a PhD must be within four years from the granting of the last doctoral degree at the time of application.
•
A minimum of 75% of the applicant’s time during the Young Investigator period must be allocated as non-clinical protected time for all research activities. This percentage of time includes both Young Investigator activities and the applicant’s other research responsibilities.

•
Research mentor(s) must be identified and have a track record in pediatric cancer research. If no such record exists, a co-mentor with such a record must be identified. The application must document the mentor(s) involvement in experimental design and execution. A detailed plan for training activities is required and will be weighed heavily during the application review.
At the time of application or successful award
•
Applicants must not hold an NIH independent (R or P Award) or individual training (F or K Award) grant. Institutional training grants (KL2, K12, T32) are permitted. Funding from other foundations is permitted provided there is no scientific or budgetary overlap.

Eligible Countries:

Canada

United States

Sponsor Details

Sponsor Institute/Organizations: Alex's Lemonade Stand Foundation

Sponsor Type: Corporate/Non-Profit

Address: 333 E. Lancaster Ave, #414, Wynnewood, PA 19096 USA

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