The goal of VISIBLE is to increase the proportion of women presenting with stable angina who receive effective diagnosis and treatment for coronary microvascular disease from less than 1% to more than 80%, without increasing the risk of missed diagnosis or treatment of obstructive coronary artery disease. In so doing, the program aims to demonstrate advances capable of reducing the burden of cardiovascular disease for millions of women worldwide.
Central to the program is the recognition that coronary microvascular disease encompasses multiple endotypes with distinct, yet overlapping, pathophysiological mechanisms, including functional and structural abnormalities. By refining and validating these endotypes, the program aims to move beyond empiric care toward mechanism-informed diagnosis and treatment.
Performers from universities and research institutions: small, medium, and large companies (including venture-backed); and government or non-profit research organizations are invited to propose.
Wellcome Leap accepts project proposals from any legal entity, based in any legal jurisdiction, including academic, non-profit, for-profit, and regulatory/professional organizations. Applicants are encouraged to contact Wellcome Leap about joining its Health Breakthrough Network by executing its MARFA (or CORFA for commercial entities) agreement. Full execution of the Wellcome Leap MARFA is not required for application submission but is required for any award.
Sponsor Institute/Organizations: Wellcome Leap Inc
Sponsor Type: Corporate/Non-Profit
Address: 302 Washington St 150-1384, 92103
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Mar 09, 2026
Mar 09, 2026
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Affiliation: Wellcome Leap Inc
Address: 302 Washington St 150-1384, 92103
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