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URSO Student Fellowship

CurePSP

The URSO Student Fellowship supports students conducting summer research projects focused on PSP, CBD, and related diseases. This program is supported by the Paul and Ruth Urso Memorial Research Fund. The goal of this fellowship program is to encourage students and trainees to pursue research in this field in the hope of making PSP or CBD a long-term area of research interest.. Projects may be in basic, translational, clinical or epidemiological aspects of PSP and CBD.

AI Based Application Success Predictor

1️⃣ Direct and Specific Focus on PSP or Related Tauopathies (Most Important)

CurePSP funds PSP-focused or primary tauopathy-focused work — not broad neurodegeneration unless PSP relevance is very clear.

Successful proposals:

Use PSP or pure-tauopathy models

Address mechanisms specific to 4R tau pathology

Include PSP patient samples or PSP-relevant brain tissues

Discuss how findings advance PSP understanding directly

Predictor: PSP/tauopathy specificity is essential for competitiveness.

2️⃣ Strong Translational Potential Toward Treatment or Early Detection

CurePSP heavily values projects that can lead to:

New therapeutics (small molecules, antibodies, gene therapy)

Early-phase trials

Target engagement biomarkers

Better clinical trial design or outcome measures

Predictor: Clear pathway from discovery → patient impact.

3️⃣ High-Quality Preliminary Data

Even for pilot grants, strong proposals include:

Mechanistic pilot data

Tau pathology modulation in cell or mouse models

Feasibility evidence for biomarker or imaging approaches

Retrospective analyses supporting hypotheses

For early-career awards, limited preliminary data is acceptable only if the rationale is very strong.

Predictor: Evidence of feasibility reduces reviewer risk concerns.

4️⃣ Use of Robust, Relevant Tauopathy Models

Reviewers expect:

4R tau transgenic mice

PSP-like tauopathy cell models

Human iPSC-derived neurons or glia

Postmortem PSP tissue from brain banks

PET imaging with tau tracers

Weak or non-specific models score poorly.

Predictor: Use of validated, PSP-relevant models.

5️⃣ Focus on High-Value Scientific Topics in PSP

Priority areas include:

Tau seeding & propagation

Tau PTMs (phosphorylation, acetylation, truncation)

Neuroinflammation & glial biology (astrocytes, microglia)

Synaptic dysfunction

Mitochondrial and axonal degeneration

Oligodendroglial involvement (important in PSP anatomy)

Regional vulnerability (brainstem, basal ganglia)

Predictor: Alignment with PSP pathobiology mechanisms.

6️⃣ Clear, Feasible, Milestone-Oriented Plan

Successful proposals show:

Logical, stepwise aims

Achievable 1–2 year scope

Quantifiable deliverables

Risk-mitigation strategies

Use of appropriate statistical and experimental design principles

Predictor: Feasibility + rigor.

7️⃣ Strong Team & Environment

Reviewers look for:

Expertise in tau biology, neurodegeneration, or PSP clinical care

Access to necessary models, brain tissue, PET imaging, or PSP patients

Collaborations with PSP centers or CurePSP Centers of Care

Junior investigators paired with senior PSP experts

Predictor: Credible team with required domain expertise.

8️⃣ Biomarker Integration (Highly Valued)

CurePSP increasingly prioritizes biomarkers, including:

CSF/plasma tau species

Neurofilament light (NfL)

Tau PET ligands

Digital gait/posture/eye-movement markers

Proposals including biomarker development or validation score higher.

Predictor: Biomarker relevance boosts translational impact.

🚫 COMMON PITFALLS (Why CurePSP Applications Fail)

Pitfall	Why It Weakens Score
Not PSP-specific (general Alzheimer’s/tau work)	Misaligned with mission
Overly ambitious with too many aims	Feasibility concerns
Weak preliminary data	High perceived risk
Poor choice of models (non-tauopathy or unrelated)	Scientific mismatch
Lack of clinical/translational pathway	Low impact
No biomarker or outcome-measure relevance	Misses CurePSP strategy priorities
Insufficient expertise in tau/PSP	Execution concerns

Specialties

Cancer

Eligibility Requirements

Undergraduate, graduate, and medical students are eligible – as well as medical residents and clinical fellows. Postdoctoral fellows are not eligible for this program. The research must be performed under the supervision of a faculty mentor with expertise in the field. Funds may be budgeted to cover the applicant’s stipend and research related expenses.

Sponsor Details

Sponsor Institute/Organizations: CurePSP

Sponsor Type: Corporate/Non-Profit

Address: 325 Hudson Street 4th Floor New York, NY 10013

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