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UNITE Open Calls: Second Open Call for Digital Health Innovators

UNITE - European Digital Health Valleys

Are you a digital health innovator in one of the UNITE regions? The Second UNITE Open Call, offering €6 million in financial support for breakthrough solutions that will transform European healthcare, is now open.

UNITE Framework

UNITE is a major €20 million pan-European programme under the European Commission's Regional Innovation Valleys initiative, which builds a borderless European digital health innovation ecosystem and drives healthcare transformation through digital deep-tech solutions, addressing challenges posed by demographic transitions and ageing populations.

Key Call Details & Timeline

Important Dates:

Call opening: September 10, 2026
Information session: September 30, 2026
- View recording
- Download presentation
Submission deadline: December 10, 2026
Project duration: April 1, 2027 – September 30, 2028 (18 months)

Financial Support:

Total budget: €6,000,000
Maximum funding per project: €1,000,000
Maximum funding per organisation: €600,000 (including all UNITE open calls)

Innovation Challenges

The second UNITE Open Call supports innovative digital solutions addressing two key challenges:

1. Deep-tech innovations to secure equal health for the entire population

Solutions that:

Support greater autonomy for elderly and disadvantaged populations
Deliver more personalised care tailored to individual health needs
Integrate fragmented healthcare services

2. Digital solutions to battle the health workforce crisis

Solutions that:

Alleviate healthcare staff shortages through digital tools and automation
Streamline clinical workflows and improve operational efficiency
Address skill gaps through accessible training, education, and upskilling opportunities

Consortium Requirements

Each consortium must include minimum 3 organisations from 3 different UNITE regions:

At least 1 company or other close-to-market solution provider
At least 1 research entity supporting the company from any perspective
At least 1 end-user organization demonstrating the solution in real-life settings

Each consortium must respect the regional balance and include:

At least 1 organisation from a strong innovation region (Wales, Scotland)
At least 1 organisation from a moderate or emerging region (Central Macedonia, Romania, Lombardy, Extremadura, Aragón)

Ecosystem Value and Support

The UNITE’s borderless European digital health innovation ecosystem offers access to:

Financial support up to €1 million per project
Tailored matchmaking opportunities with compatible European organisations
Curated events and networking activities
Hands-on support to transform ideas into compelling cross-border project proposals
Over 100 organisations from the private and public sectors, academia, and civil society, spanning all UNITE regions

AI Based Application Success Predictor

Organization	UNITE – European Digital Health Valleys
Organization type	EU-funded, multi-region digital health innovation project
Funding source	European Union, through Horizon Europe
Project coordinator	28DIGITAL, Belgium
Primary topic areas	Digital health, healthcare innovation, health data interoperability, remote care, health workforce solutions, and healthy ageing. European Commission +1
Funding mechanism	Open calls providing financial support to third-party innovation projects
Current funding opportunity	Open Call 2 for Joint Interregional Projects
Total available funding	€6 million
Deadline	10 December 2026, 17:00 Brussels time. European Commission +1

Previous grant success predictors

Predictor	Importance for selection
Innovation and technical quality	Demonstrates a novel, technically credible digital health solution.
Alignment with challenge areas	Addresses equitable healthcare access, remote care, health data interoperability, or the healthcare workforce crisis.
Interregional collaboration	Establishes a strong partnership across eligible UNITE regions.
Real-world implementation	Includes a credible plan to pilot and validate the solution in healthcare settings.
User and patient benefits	Demonstrates measurable benefits for patients, healthcare professionals, or care providers.
Feasibility and scalability	Presents achievable milestones and a pathway to expand the solution across regions.
Consortium quality	Brings together complementary technology providers, research organizations, and end-user organizations, as required by the call.
Commercialization potential	Explains the business model, adoption pathway, and sustainability of the innovation.
Measurable impact	Defines relevant KPIs, expected outcomes, and a robust monitoring plan.
Budget and implementation plan	Provides a realistic budget, clear responsibilities, and a credible delivery timeline.

These predictors are based on the published project objectives and funding requirements, not a statistically validated ranking of historical award-winning factors.

UNITE

Excel-ready entry — Previous Success Predictors

Digital health innovation; technical quality; alignment with UNITE challenges; interregional collaboration; real-world pilot feasibility; patient and healthcare workforce impact; consortium strength; scalability; commercialization potential; measurable KPIs; implementation plan; budget justification; and eligibility compliance.

Specialties

Health Informatics

Eligibility Requirements

Applicants must be legally established in and comply with the requirements of the following UNITE participating regions:

Central Macedonia, Greece
Lombardy Region, Italy
Extremadura Region, Spain
Aragón Region, Spain
Scotland, United Kingdom
Wales, United Kingdom
Romania, national scope

Eligible Countries:

Greece

Italy

Romania

Spain

United Kingdom

Sponsor Details

Sponsor Institute/Organizations: UNITE - European Digital Health Valleys

Sponsor Type: Corporate/Non-Profit

Address: Rue Guimard 7, 1040 Brussels

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