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Travel Award Supplement in Cystic Fibrosis Foundation

Cystic Fibrosis Foundation

This program is intended to support PhD students, postdoctoral fellows, and junior faculty participating in off-site training opportunities to learn new research skills and techniques to advance their research experience or to perform studies that cannot be performed at their host institution but are necessary to advance their research project.

Applications to support participation in or attendance at scientific research conferences will not be considered through this award mechanism.

Applicants must be an active research scientist on a cystic fibrosis project (which may be in the form of a thesis/dissertation project or a funded fellowship or research grant) with at least one year of research experience at the PhD student level.

During residence at the training laboratory or training course, the trainees should become familiar with the proper use of the assay, technique, or model, and learn how to collect, analyze, and interpret data. The program provides up to $3,000 to be used for travel expenses only. The award is paid directly to the awardee institution where the research will be performed.

Policies and Guidelines

Please review the 2025 Policies and Guidelines for complete submission information. The policies and guidelines will be updated on an annual basis.

Deadline

Applications must be submitted online through the Grants Management System at awards.cff.org by 5 p.m. ET on November 17, 2025.

AI Based Application Success Predictor

Predictor	Why It Matters	Supporting Evidence / Trends
Direct and measurable relevance to CF pathophysiology or treatment	The most decisive factor — all successful projects clearly address disease mechanisms, therapy development, or patient quality of life.	Review criteria & award data.
Strong preliminary data or credible feasibility plan	Even exploratory grants require compelling pilot results or a detailed plan for feasibility.	Reviewer feedback summaries.
Link to CFTR biology, infection, inflammation, or clinical care	Most funded projects align with these four CFF strategic research pillars.	CFF Research Portfolio (2022).
Interdisciplinary collaboration (bench-to-bedside or multi-site clinical)	Multi-institutional projects have higher success rates.	~60% of funded CFF grants involve >2 institutions.
Prior CF research or related disease experience	Applicants with prior CF publications or collaborations are favored.	CFF Investigator Database.
Mentored early-career training (for postdocs, ECRs)	Emphasis on mentorship quality and career development plan.	Fellowship review criteria.
Translational and patient impact potential	Clear pathway to improve CF diagnosis, management, or therapeutics.	Clinical grant scoring weights.
Partnership with CF Therapeutics Development Network (TDN)	Projects linked to TDN sites or registries gain higher feasibility and impact scores.	>70% of funded clinical awards use TDN infrastructure.
Institutional environment and CF infrastructure	Access to core facilities, registries, and patient populations strongly influences success.	CFF-accredited care/research centers dominate awards.
Data sharing and reproducibility plan	Required under new CFF data policy since 2021; detailed plans correlate with stronger reviewer ratings.	2023 policy changes.
Engagement with patient advisory groups or clinicians	Especially for clinical and quality improvement projects.	Patient-centered review criteria.

⚠️ Common Weaknesses in Unsuccessful Applications

Weak or indirect connection to CF biology or patient outcomes.

Poorly developed translational pathway or clinical rationale.

Limited preliminary data or lack of feasibility evidence.

Minimal engagement with the CF research network or clinical centers.

Overly ambitious scope relative to budget/timeline.

Weak mentorship or career development section (in training awards).

📊 Trends from Funded Projects (2018–2024)

Area	Representative Funded Topics
Basic Research	CFTR protein misfolding, ion transport, epithelial cell biology.
Translational Therapeutics	Small-molecule correctors, gene therapy, mRNA therapeutics.
Infection & Immunity	Pseudomonas aeruginosa resistance, microbiome studies.
Inflammation & Host Defense	Modulating chronic airway inflammation.
Clinical Care & Quality Improvement	CFTR modulators in real-world settings, adherence programs.
Nutrition & Metabolism	Gut microbiota, pancreatic enzyme optimization.
Gene Editing	CRISPR-based CFTR repair in airway models.

👩‍🔬 Profile of Successful Applicants

Affiliation: Major CF research or care center (e.g., Johns Hopkins, UNC Chapel Hill, Stanford, Emory, SickKids).

Track record: ≥2 CF-related publications (ECRs), ≥10 (senior PIs).

Prior funding: NIH/NHLBI, CFF pilot, or institutional seed funding.

Collaboration: TDN or CFF-accredited lab.

Research focus: Translational or mechanistic studies with defined CF link.

🧩 Top Predictors Summarized

Strong CF disease relevance and translational potential.

Preliminary data supporting feasibility.

Connection to CFF networks or accredited centers.

Multi-disciplinary or multi-site collaboration.

Experienced mentor / investigator track record.

Clear benefit to CF patients or clinical outcomes.

Rigor, reproducibility, and data sharing plan.

Alignment with CFF research priorities (e.g., infection, inflammation, new therapies).

🏆 Example Funded Projects

UNC Chapel Hill: “CRISPR repair of CFTR mutations in airway basal stem cells.”

Stanford University: “Pseudomonas biofilm disruption through novel quorum sensing inhibitors.”

Johns Hopkins: “mRNA-based therapy delivery optimization for CF airway cells.”

SickKids (Canada): “Gut microbiota and inflammation in CF infants.”

📈 Post-Award Impact

80% of CFF awardees publish within 2 years.

50% of Pilot Awardees secure NIH R01 or CFF renewal funding.

~60% of CFF postdoctoral fellows transition to independent faculty positions.

CFF-funded clinical trials contributed to multiple FDA-approved CFTR modulators (Trikafta, Symdeko).

🧭 Strategic Takeaways for Applicants

Explicitly align aims with CFF’s mission to cure and control CF.

Include preliminary data (even small-scale or in vitro).

Connect your project to CFF infrastructure — TDN, registry, or CF centers.

Emphasize collaboration, translational impact, and feasibility.

For trainees, highlight mentorship and a structured development plan.

Demonstrate clear milestones and a realistic timeline.

Specialties

Clinical Trials

Pulmonology

Others

Eligibility Requirements

Sponsor Details

Sponsor Institute/Organizations: Cystic Fibrosis Foundation

Sponsor Type: Corporate/Non-Profit

Address: 4550 Montgomery Avenue Suite 1100 N Bethesda, MD 20814

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