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Research grants in Oxalosis & Hyperoxaluria Foundation

Oxalosis & Hyperoxaluria Foundation

The OHF seeks to support research that will ultimately lead to new diagnostics, treatments, and a cure for Primary Hyperoxaluria and related Hyperoxaluria conditions.

Support

• Applications for up to two years of support will be considered. These funds may be used in the following categories: Personnel, Supplies, Other Costs, Travel, and Equipment. Indirect costs up to 10% of the direct costs (excluding equipment) may be requested

Maximum Funding • $200,000.00 for up to two years. Indirect costs must be included in the maximum funding amount.

Deadline Date • December 15th

• Notification of Award May 1st

AI Based Application Success Predictor

1. Direct and explicit relevance to hyperoxaluria

Panels strongly prefer projects that:

Directly investigate oxalate metabolism/handling

Target disease progression

Address complications (nephrolithiasis, renal failure, systemic deposition)

Projects where the hyperoxaluria angle is secondary tend to fail.

2. Patient-impact proximity

Successful proposals show how the work will:

Improve diagnosis

Guide therapy selection

Reduce morbidity (e.g., kidney damage, bone involvement)

Shorten diagnostic delays

Aid clinical decision-making

Impact within 3–5 years is a positive signal.

3. Novel therapeutic or mechanistic insights

Winners often propose:

New metabolic targets

RNAi mechanistic exploration

Microbiome modulation

Crystal inhibition strategies

Gene therapy-related pathways

Incremental descriptive work is less competitive.

4. Integration of patient samples / clinical phenotype

Panels reward:

Patient-derived cells

Urine/serum oxalate profiling

Biobank leverage

Longitudinal data

Pure in vitro without clinical anchoring performs worse.

5. Feasibility within grant size

OHF grants are typically modest. Successful projects:

Have well-constrained aims

Avoid “omics everything”

Use existing infrastructure

Scope control is a major predictor.

6. Demonstrated expertise in nephrolithiasis, metabolic disease, or renal genetics

Track record matters:

Publications on metabolic kidney disease

Crystal pathology experience

Pediatric nephrology exposure

Metabolite quantification methods

Generalists without domain depth underperform.

7. Collaborations with clinical nephrologists

Patterns show higher success when:

A clinician collaborator is listed

There’s access to relevant patient populations

There’s care pathway knowledge

8. Biomarker development angle

Winning proposals often include:

Prognostic signatures

Early disease markers

Treatment-response indicators

Surrogate outcomes for trials

This aligns with OHF’s translational priorities.

🧫 Experimental Method Themes That Score Higher

Successful applications frequently incorporate:

Oxalate transport assays

Intestinal absorption modulation

Enzyme kinetics for AGXT/GRHPR/HAO1

Crystal cell-toxicity assays

Imaging of crystal deposition

Microbiome oxalate degradation pathways (e.g., Oxalobacter)

🔬 Emergent Predictors (recent cycles)

1. RNA-based therapeutic exploration

Interest increased post-lumasiran.

2. Quality-of-life and psychosocial work

Growing support for:

caregiver burden

adherence challenges

diagnostic odyssey narratives

3. Gene and enzyme replacement approaches

Forward-looking but feasible = high score.

📉 Common Reviewer Critiques (patterns)

“Cancer/metabolic link too indirect”

“Limited sample size justification”

“No plan for assay validation”

“Aims overly ambitious”

“Contingency plans missing”

“Underdeveloped clinical relevance”

🧠 Rigor & reproducibility predictors

Panels respond well to:

Replicate plan clarity

Power justification (even for pilot scale)

Standardized oxalate measurement protocols

Defined statistical analysis pipelines

Vagueness → lower enthusiasm.

🧪 Assay infrastructure access

Positive signal predictors:

validated LC-MS for oxalate

standardized metabolomics pipelines

micro-CT imaging for crystal deposition

patient registries

🧵 Patient registry utilization

OHF projects that integrate:

the OHF patient registry

natural history data

longitudinal kidney outcomes

tend to perform better.

🤝 Community & foundation engagement

Successful awardees tend to:

have prior presentation at OHF meetings

participate in hyperoxaluria working groups

demonstrate patient involvement

These are soft but meaningful predictors.

🧬 Study Design Predictor

Winning projects often include a:

mechanistic aim,

biomarker aim,

feasibility/translation aim.

Two strong aims beat three weak ones.

💰 Budget Efficiency Signals

Panels value:

use of existing platforms

limited new equipment

cost-effective assays

realistic personnel allocations

🔎 Reviewers’ Value Hierarchy (inferred)

Patient impact within disease context

Clear hyperoxaluria mechanistic relevance

Feasibility with requested funds

Biomarker or clinical translation

Investigators’ domain expertise

Use of patient-derived resources

Contingency planning

🧞‍♂️ Ideal PI/Project Traits (pattern)

Experience in metabolic kidney disease

Publications in nephrology/crystal biology

Access to clinical specimens

Proximity to therapeutic application

Efficient use of funds

Clear milestone timeline

🏁 Summary: Strongest Predictors of Success

A highly competitive OHF proposal typically exhibits:

✅ Direct disease-pathway relevance
✅ Clear path to patient benefit
✅ Mechanistic novelty (not descriptive)
✅ Patient sample integration
✅ Realistic, milestone-based scope
✅ Clinical collaborator involvement
✅ Rigor in metabolite quantification
✅ Budget proportionality

Specialties

Clinical Trials

Urology

Eligibility Requirements

• Applicants must hold a MD, PhD. or equivalent by the time of the start of the funding period and have an appointment at an academic institution.

• Compliance with local and federal statutes and regulations of the country of origin must be met.

Revised grant applications submitted require a 2---page introduction addressing the Reviewers' comments from the prior review of the grant application.

Sponsor Details

Sponsor Institute/Organizations: Oxalosis & Hyperoxaluria Foundation

Sponsor Type: Corporate/Non-Profit

Address: 579 Albany Post Road New Paltz, NY 12561

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