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Research Grant Program on the Effects of Air Pollution and Climate Change on Carcinogenesis and Lung Cancer Prevalence

Lung Cancer Research Foundation

Lung cancer is responsible for more deaths worldwide than any other cancer. The last 10-15 years have seen accelerated clinical trials and FDA approvals of targeted therapies for non-small cell lung carcinoma (NSCLC) in part due to advances in molecular profiling of tumors. Many of these targeted therapies are directed against oncogenic drivers. The HER family of tyrosine kinases include HER1 (epidermal growth factor receptor [EGFR] or ERBB1), HER2 (HER2/neu or ERBB2), HER3, and HER4. EGFR mutations were one of the first oncogenic drivers that were successfully targeted with the use of tyrosine kinase inhibitors. Despite substantial progress in this area, available treatments are generally not curative, and resistance invariably develops. HER2 mutations have also been identified as potential oncogenic drivers in lung cancer.

It is of vital importance that there is a better understanding of the biology of HER2-mutated lung cancer as well as the mechanism of tumor response and resistance. Moreover, given that therapeutic options available to date are not curative, there is a need for novel approaches to treat HER2-mutant lung cancers.

Specialties

Cancer

Pulmonology

Oncology

Eligibility Requirements

Investigators must be affiliated with a non-profit academic or research institution. Applicants may be at any level in their career. Applicants from post-doctoral researchers; clinical fellows; or early-, mid-, or senior career investigators are eligible to apply. Applications from US-based and international organizations are welcome and may hold any residency/citizenship status. Inquiry related to eligibility should be sent to LCRF grants office (see Inquiries section below) before submitting an application and at least a week before submission deadline

Sponsor Details

Sponsor Institute/Organizations: Lung Cancer Research Foundation

Sponsor Type: Corporate/Non-Profit

Address: Philadelphia, PA

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