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Real-World Data Generation with Elranatamab in Relapsed/Refractory Multiple Myeloma

Pfizer

Overview

This competitive grant program seeks to support research studies that focus on generating evidence on the use of elranatamab in Multiple Myeloma (MM) in the real world/clinical practice setting1. Patients with relapsed or refractory multiple myeloma (RRMM) generally experience poor response rates and survival outcomes, particularly those treated in later lines of therapy, including triple-class-exposed (TCE) patients2. Given the recent approval of elranatamab and the limited real-world experience in TCE RRMM3-4, real-world data are needed to generate robust evidence on its effectiveness and safety in routine clinical practice.

Project Types and Area of Interest

Projects that will be considered for Pfizer support will focus on:

• Real world evidence (RWE) and observational studies assessing safety, effectiveness, and treatment patterns

• Comparative and sequencing analyses evaluating outcomes across prior therapies and lines of treatment

• Subgroup and disparity research focused on populations under represented in clinical trials

• Patient centered outcomes research, including Patient‑Reported Outcomes (PROs), caregiver burden, and adherence

• Translational and biomarker research to understand mechanisms of response, resistance, and relapse

Funding Range and Project Length

Total available budget related to this RFP is approximately 250,000€. Individual projects requesting up to 120,000€ will be considered, although smaller requests (around 60,000€) are also encouraged. Projects are encouraged to begin from September 2026 onwards, for a maximum duration of 26 months.

AI Based Application Success Predictor

Direct alignment with Pfizer’s therapeutic focus areas, such as:
- Oncology
- Vaccines
- Inflammation & Immunology
- Rare diseases
Projects addressing unmet medical needs are prioritized

👉 Misalignment with Pfizer’s current RFP (Request for Proposals) is a major rejection factor

🎯 2. Clear Impact on Patient Outcomes

Pfizer strongly favors proposals that demonstrate:

Improved patient care or clinical outcomes
Real-world applicability (not purely theoretical research)
Measurable endpoints (e.g., survival, quality of life, adherence)

👉 Compared to academic grants, practical impact is more heavily weighted

🧪 3. Robust Study Design & Methodology

Successful applications typically include:

Well-defined study protocols
Appropriate statistical plans
Feasible recruitment strategies

👉 Weak methodology is one of the most common rejection reasons

👩‍⚕️ 4. Investigator Credentials & Track Record

Proven publication record in the relevant field
Prior clinical research experience
Institutional support and infrastructure

👉 Early-career applicants can succeed, but usually with:

Strong mentorship
Clear feasibility

🏥 5. Institutional Capability

Access to:
- Patient population
- Clinical facilities
- Data management systems
Experience in conducting industry-sponsored trials

🤝 6. Independence & Transparency

For Pfizer grants (especially IIR):

Research must be investigator-initiated and independent
Clear disclosure of:
- Conflicts of interest
- Data ownership
Pfizer does not control study outcomes

💰 7. Realistic & Justified Budget

Budget must align with:
- Study scope
- Timeline
Overinflated or vague budgets reduce success chances

📑 8. Compliance with RFP Requirements

Strict adherence to:
- Proposal format
- Submission guidelines
- Required documentation

👉 Non-compliance can lead to automatic disqualification

🌍 9. Geographic & Strategic Priorities

Pfizer often prioritizes:
- Regions with high disease burden
- Projects aligned with global health strategies

⏳ 10. Feasibility & Timeline

Clearly achievable milestones
Realistic timelines
Defined deliverables

📊 Summary: Key Predictors (Ranked)

Highest impact factors:

Alignment with Pfizer RFP & therapeutic area
Patient-centered impact
Strong methodology

Moderate predictors:
4. Investigator track record
5. Institutional capability
6. Feasibility

Supporting factors:
7. Budget clarity
8. Compliance
9. Independence & transparency

💡 Insider Insight

Unlike Horizon Europe or NIH-type grants:

👉 Pfizer funding is more application-driven than theory-driven
👉 “Will this improve patient care soon?” is the central evaluation lens

Specialties

Neurosciences

Pharmaceuticals

Others

Eligibility Requirements

• The institution and Principal Investigator (PI) must be based in Spain.

• Only organizations are eligible to receive grants, not individuals or medical practice groups (i.e., an independent group of physicians not affiliated with a hospital, academic institution, or professional society).

• If the project involves multiple departments within an institution and/or between different institutions / organizations / associations, all institutions must have a relevant role and the requesting organization must have a key role in the project.

• The PI must have a medical or postdoctoral degree (MD, PhD, or equivalent), an advanced nursing degree (BSN with a MS/PhD), or a degree in Pharmacy, Physiotherapy, or Social Work.

• The applicant must be the PI or an authorized designee of such individual (e.g., PI’s research coordinator).

• The PI must be an employee or contractor of the requesting organization.

• Requesting organization must be legally able to receive award funding directly from Pfizer International LLC. We strongly recommend that applicants confirm this with their organization or institution prior to submitting an application. Grants awarded to organizations that are subsequently found to be unable to accept funding directly from Pfizer International LLC may be subject to rescission.

Eligible Countries:

Spain

Sponsor Details

Sponsor Institute/Organizations: Pfizer

Sponsor Type: Corporate/Non-Profit

Address: 66 Hudson Boulevard East, New York, NY 10001-2192

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