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Pilot Research Program

Southwest National Primate Research Center

Important dates/Timeline:

Submit Letter of Intent (LOI)	November 3, 2025
Notification of Approval to Submit Application	November 15, 2025
Submit a Veterinary Resources Request Form (if invited)	December 12, 2025
Submit Completed Application (if invited)	January 23, 2026
Decision Letters Sent	March 18, 2026

PURPOSE

The SNPRC Pilot Research program provides opportunities and support for investigators to use SNPRC nonhuman primate resources in highly focused, short-term studies with a high likelihood of enhancing the value, utility, feasibility, and attractiveness of nonhuman primates for biomedical research. High priority will be given to studies that propose to generate preliminary data for applications to the National Institutes of Health (NIH) for support of future research projects. Those proposing to develop new nonhuman primate models of disease, or develop and/or test new research methods, instrumentation, or approaches for biomedical research using nonhuman primates, also will be considered responsive to the goals of the program.

Sponsors

Any applicant who is not an SNPRC Core Scientist must be sponsored by an SNPRC Core Scientist. The Sponsor will be an aid in guiding the applicant through SNPRC administrative processes. The participation of a SNPRC Core Scientist in pilot studies funded by this program is an NIH mandate. If the application is accepted, SNPRC will handle the sponsor assignment.

Supported Activities/Allowable Uses of Pilot Research Program Funds

For the 2026 competition, the proposed research activities may use any of our supported species: marmosets, rhesus macaques, or baboons. However, due to limited animal availability, preferential consideration will be given to applications focused on baboons, or non-terminal rhesus/marmoset studies that can utilize non-naive animals.
In addition to preferential consideration for species, proposals that emphasize topics that relate to Comparative Medicine & Health Outcomes are also being encouraged in the 2026 competition.
Pilot research funds may not be used to provide support for projects currently or previously funded by other sources.
Funds awarded in support of pilot research must be used to cover SNPRC costs:
- Animals and animal care costs (including per diem)
- Animal research procedures conducted by SNPRC personnel
- SNPRC Laboratory Cores (Pathology, Imaging or Integrative Biology Core) https://snprc.org/laboratory-core/
Funds awarded in support of pilot research may not be used to cover costs of supporting laboratory personnel, supplies, service fees for equipment, publication fees. travel or work carried out at off-site locations.
If the project anticipates the use of the SNPRC Research Imaging Core, the applicant must consult with the Core’ lead, Dr. Kimberley Phillips (kphillips@TxBiomed.org) prior to submitting a Letter of Intent to ensure that the proposed activities can be conducted by the Core and the applicant understands any additional imaging expenses associated with the project that would not be covered by the Pilot Grant.
Proposal budgets will be capped at $100,000. The decision will be based on funding status.
Funding for awarded studies will initiate May 1, 2026 and expire on April 30, 2027. There is no option for no-cost extensions or carry-forward.

AI Based Application Success Predictor

Success with SNPRC funding (especially pilot research awards) revolves around scientific relevance, feasibility, and strategic alignment with both SNPRC and NIH priorities.

1. Alignment with SNPRC Mission and NIH Priorities

SNPRC’s mission is to improve health through non-human primate research and to support studies that make primate models valuable for biomedical science.

Success predicts when projects:

Focus on biomedically relevant questions such as infectious disease, immunology, metabolic disease, aging, and translational models that are best addressed in primates.

Are positioned to generate preliminary data for future external funding (e.g., NIH R01/U01/U19).

Tip: Frame your work in terms of biomedical impact and fit with primate models.

2. Clear Scientific Merit & Hypothesis-Driven Design

Competitive proposals articulate:

A clear hypothesis or research question.

Sound study design, including choice of species (baboons, rhesus, or marmosets) appropriate to the question.

A feasible plan with defined procedures and timelines that align with the resources available at SNPRC (e.g., cores, animal care).

Proposals that develop or refine primate models of disease or innovative methods are considered especially responsive to program goals.

3. Strong Preliminary Data or Justification of Feasibility

While pilot grants are often meant to produce preliminary data, reviewers look for evidence that the project:

Is grounded in solid rationale or existing results.

Will produce data useful for subsequent NIH or major peer-reviewed funding applications.

Including any preliminary findings, relevant pilot work, or solid literature justification strengthens reviewer confidence.

4. Institutional and Regulatory Preparedness

Proposals should demonstrate that the research environment and team can execute primate work by showing:

Institutional approvals (e.g., IACUC) are planned or attainable.

The team has access to required facilities and expertise (including necessary labs and animal care).

A clear sponsor relationship with an SNPRC Core Scientist (required if the applicant is external).

Tip: Address ethical and regulatory compliance clearly — primate work requires stringent oversight.

5. Strategic Use of SNPRC Core Services

Proposals that integrate SNPRC core facilities or support (e.g., imaging, pathology) often score better because they:

Demonstrate collaboration with existing infrastructure.

Show practical planning that uses SNPRC’s unique strengths.

Tip: Discuss use of cores and consult with core leads early in planning.

6. Realistic Budget and Resource Request

SNPRC Pilot funding typically has a budget cap (~$100,000) and must cover direct SNPRC costs such as animal care, procedures, and use of cores — not off-site work or indirect costs.

Predictor: Budgets that clearly justify how funds support the project goals and stay within allowable costs are more competitive.

7. Engagement with SNPRC Review Process

SNPRC uses a two-stage review for pilot grants:

A Letter of Intent is reviewed by leadership to determine invitation to full application.

Full applications are reviewed by a Research Advisory Committee (RAC) plus ad hoc experts.

A strong LOI that convincingly communicates significance, feasibility, and alignment increases chances of full submission.

8. Plans to Disseminate and Leverage Results

Investigators who present plans for:

Publication in peer-reviewed journals,

Presentations at scientific meetings,

Follow-on funding proposals (e.g., NIH R01 or other grants),

…demonstrate value and return on investment, increasing competitiveness.

Tip: Include clear dissemination and future funding plans.

🧠 Summary Checklist for Competitive SNPRC Applications

Core Predictors of Success:
✔ Strong alignment with primate-based biomedical research priorities.
✔ Clear, hypothesis-driven design feasible within SNPRC capabilities.
✔ Evidence of pathways to future large grants (e.g., NIH).
✔ Institutional and regulatory readiness (IACUC/approvals).
✔ Realistic budget tied to allowable costs.
✔ Strategic use of SNPRC core services.
✔ Clear communication in the LOI.
✔ Plans for dissemination and follow-on funding.

Specialties

Biomedical Engineering

Others

Eligibility Requirements

Investigators at the Staff Scientist (Research Assistant Professor) through Full Scientist (Full Professor) or equivalent positions at institutions meeting the requirements to apply for, receive, and administer grants in aid of research from the NIH are eligible to apply.

Eligible Countries:

United States

Sponsor Details

Sponsor Institute/Organizations: Southwest National Primate Research Center

Sponsor Type: Corporate/Non-Profit

Address: P.O. Box 760549 San Antonio, TX 78245-0549

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