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Pathway and Pipeline Grant Program

CurePSP

Applications for the Pathway and Pipeline program open July 1, 2025, and are due October 15, 2025, at 5pm ET. View application instructions and eligibility here, and apply through ProposalCentral.

Through the Pathway and Pipeline Grant program, CurePSP provides seed funding to early career investigators who have innovative ideas that need proof of concept or pilot studies in order to qualify for larger funding sources. CurePSP provides grants to scientists of up to $100,000 for one- or two-year studies. Proposals are carefully evaluated by our Scientific Advisory Board (SAB) in collaboration with our Executive Director and the Board of Directors.

CurePSP will fund studies on PSP and CBD through two avenues, the pathway grants or pipeline grants program.

Pathway grants support projects studying the fundamental neurobiology of PSP and CBD. A more complete understanding of the underlying basic science and mechanisms of PSP and CBD will improve understanding of the diseases and provide the foundation for future treatments. Studies focusing on mechanisms common to multiple neurogenerative are strongly encouraged.

Examples of pathway grant topics include (but are not limited to) tau biology and pathobiology, epigenetics and epigenomics, synaptic dysfunction/lost and pruning, neuroinflammation, organoids, or other underlying mechanisms of PSP or CBD.

Pipeline grants support translational projects focusing on new therapeutics and biomarkers for PSP and CBD. These projects will accelerate the development of therapeutics that have the potential to prevent, treat, or cure PSP and CBD by accelerating the translation of basic science discoveries into novel therapeutics.

Examples of pipeline grant topics include (but are not limited to) symptomatic drug trials, diagnostic markers, or rehabilitation strategies for motor and nonmotor deficits.

CurePSP provides grants to scientists of up to $100,000 for one- or two-year studies. Proposals are carefully evaluated by our Scientific Advisory Board (SAB) in collaboration with our Executive Director and the Board of Directors.

These studies offer donors the opportunity to name and be involved with hand-selected and intensively administered research that provides the greatest return on investment for the donor dollar.

AI Based Application Success Predictor

Here are traits & proposal features that strong/funded CurePSP applications tend to have. These are things that appear recurrently in successful grants or in their criteria.

Predictor	How It Appears in Practice / Why It Helps
Novelty + Relevance in PSP / CBD / Tauopathies	Proposals that target unmet gaps (e.g. new biomarkers, under-studied mechanisms like sleep physiology or immune aspects) tend to resonate. Being able to make a case that the research question addresses something not already well covered gives an advantage.
Feasibility + Clear Plan for Proof-of-Concept	Because many grants are seed or preclinical, having initial pilot data, or at least a strong methodological plan, is important. Also, budget/time matching (1-2 years, or for pipelines clinical components).
Strong mentorship and institutional support	Especially for student fellowships and early career grants: having an established mentor in PSP/CBD field, access to needed models / data / facilities. Institutional backing (labs, collaborators) helps.
Alignment with CurePSP’s review bodies / mission & priorities	Demonstrating that the project aligns with CurePSP Roadmap: fundamental mechanisms, biomarker work, translation, care models. Also being able to show benefit for patients. Proposals that tie into current CurePSP initiatives (Centers of Care, CARES grants) tend to score well.
Collaboration / Multi-center or Shared Resources	CARES grants need at least two CurePSP Centers of Care, etc. Even other grants benefit from collaborators, especially for translational or clinical data work. Having access to relevant cohorts, patient populations, tissue etc. is a big plus.
Publication / Previous Track Record Relative to Stage	Even for early career, showing prior relevant work (publications, presentations) in neurodegeneration helps reviewers assess capability. For more senior grants: track record of prior grants, publications.
Clarity of Impact / Generalizability	Because CurePSP wants “publishable and generalizable data,” proposals that can explain how findings will translate or apply beyond local environments gain favor (especially clinical/care/biomarker work).
Focus on underserved populations or outreach / access	Especially in CARES grants, work focused on underserved populations, access to care, disparities, education, etc., is explicitly required. Proposals with that dimension are more likely to align with what CurePSP is trying to achieve.

Specialties

Neurosciences

Others

Eligibility Requirements

From the CurePSP announcements and policies, here are what applicants must or should satisfy:

PI (or lead applicant) must hold an advanced degree (e.g. MD, PhD, MD/PhD) in science, medicine, engineering, etc.

Institutions (academic / research) are generally eligible (international ones okay in many cases; but U.S/America-sanctioned countries excluded)

Projects need to focus on PSP, CBD, or related atypical parkinsonian/tauopathy diseases.

For student fellowships: mentored, summer projects, often under a faculty mentor knowledgeable in PSP/CBD; specific student levels allowed (undergrad, grad, medical, residents / clinical fellows); postdocs often not eligible for student fellowship track.

Grants are reviewed by a Scientific Advisory Board + Research committees; there is strong oversight and expectations of quality.

Intended to produce publishable, generalizable data (not just pilot data with no follow-through) especially in CARES and translational / clinical tracks

Sponsor Details

Sponsor Institute/Organizations: CurePSP

Sponsor Type: Corporate/Non-Profit

Address: 325 Hudson Street 4th Floor New York, NY 10013

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