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OREF Osteoarthritis Research Grant

Orthopaedic Research & Education Foundation (OREF)

Grant Details

Provides funding for research that aims to help us better understand how to prevent and treat osteoarthritis, one of the most common causes of disability in adults.

$50,000

RFA Release Date - 11/15/2025 LOI Deadline - 12/15/2025 Application Deadline - 2/16/2026

AI Based Application Success Predictor

Although different OREF grants have specific instructions and criteria, competitive proposals and awardees tend to share the following predictors of success:

🧠 1. Clear Clinical Relevance to Musculoskeletal Health

OREF places high priority on research that addresses real orthopaedic clinical problems — such as injury prevention, arthritis, fracture healing, sports medicine outcomes, spine disorders, and musculoskeletal regenerative strategies. Default

Success predictor: Projects should articulate direct relevance to patient care, quality of life, or surgical outcomes in orthopaedics.

👩‍🔬 2. Strong Hypothesis & Scientific Rationale

Proposals with a well-defined research question, solid background, and clear hypothesis are more likely to be competitive. This applies across basic, translational, and clinical topics. Default

Success predictor: Ground your work in evidence (literature, pilot data) and connect aims logically to expected outcomes.

📈 3. Feasible and Detailed Methodology

OREF reviewers look for realistic methods, clear study designs, and achievable milestones within the grant timeframe and budget. Default

Success predictor: Include detailed protocols, sample size justification (if applicable), and analytic approaches.

🧪 4. Career Development Potential

For early career mechanisms (e.g., New Investigator, Resident Grants, Mentored Clinician Scientist), career impact is a major factor — reviewers often assess whether the award propels the applicant’s research trajectory toward independence. Default

Success predictor: Demonstrate how the funding will enable key steps toward independent research and future competitiveness for larger awards.

🤝 5. Multi-disciplinary Engagement & Collaborations

Collaborations with clinicians, scientists, statisticians, or community partners strengthen many proposals by showing breadth of expertise and support. Default

Success predictor: Identify co-investigators and their roles clearly, especially for complex clinical or translational work.

📋 6. Institutional Support & Environment

Especially in career development and larger grants, institutional support (protected research time, access to facilities, mentorship) signals feasibility and reviewer confidence. Default

Success predictor: Include letters or descriptions of commitments (space, time, co-investigators).

📊 7. Alignment With OREF’s Strategic Goals

OREF supports innovative research that improves clinical practice and patient outcomes. Projects that clearly tie to OREF’s mission — improving musculoskeletal health through science — tend to resonate better with reviewers. MTEC

Success predictor: Explicitly frame your work in terms of potential clinical impact, knowledge gaps in orthopaedics, and patient benefits.

📑 8. Prior Research Productivity

Especially for larger or career grants, applicants with a track record of publications, presentations, or research leadership are generally more competitive. Default

Success predictor: Clearly present past research contributions, including abstracts and manuscripts.

📌 9. Competitive Budget Design

Budgets should be justified, realistic, and focused on activities that directly enable the proposed aims; avoid inflated or poorly aligned costs. Default

Success predictor: Detail how each item is essential to achieving the project’s milestones.

🔎 Reviewer Mindset (What They Often Ask)

OREF reviewers — often orthopaedic clinician-scientists — tend to look for proposals that:

✔ Address a significant clinical gap or challenge
✔ Propose a clear, logical research strategy
✔ Are achievable within the resources and time available
✔ Will generate meaningful data or insights valuable to orthopaedic practice
✔ Advance the applicant’s research career (especially for career awards)

Specialties

Orthopedics

Eligibility Requirements

The PI must be a new investigator. A new investigator is classified as an individual who has not received an R01 National Institutes of Health (NIH) grant or its equivalent (e.g., VA, DOD, NSF) in the role of PI. An orthopaedic surgeon principal investigator (PI) must be licensed to practice in the U. S. and be working in an institution in the U.S. Multidisciplinary research activity is always encouraged. A PhD may serve as the principal investigator (PI) if they have a primary or secondary faculty appointment in an orthopaedic department. A letter from the department chair confirming this appointment is required. DVMs are also eligible to apply.

Sponsor Details

Sponsor Institute/Organizations: Orthopaedic Research & Education Foundation (OREF)

Sponsor Type: Corporate/Non-Profit

Address: 9400 W. Higgins Road, Suite 320, Rosemont, IL 60018

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