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NPF Bridge Grants

National Psoriasis Foundation

The National Psoriasis Foundation (NPF) is offering Bridge Grants to support researchers who have submitted meritorious but unfunded K-type (career development) and R-type (investigator-initiated) applications to the National Institutes of Health (NIH), or similar funding body, with a focus on psoriatic disease or its comorbidities. Through this opportunity, NPF provides a critical year of additional support until additional funding can be secured. In line with NPF’s mission, Bridge Grants will help support those with a long-term commitment to psoriatic disease research, and who will go on to make discoveries that bring us closer to a cure for psoriatic disease and improve patients’ lives.

Budget and Project Period

Applicants may request up to $50,000 (direct costs only) for a K-type bridge or up to $100,000 (direct costs only) for an R-type bridge per year. The total project period for the application submitted is one year, from October 1st to September 30th.

Application

Applications for the 2026 funding cycle are due Friday, January 30, 2026, at 5:00 p.m. ET. Award notifications are anticipated by June 30.

AI Based Application Success Predictor

1. Explicit Focus on Psoriasis / Psoriatic Arthritis

The strongest predictor is that the proposal directly advances understanding or treatment of:

Psoriasis (plaque, guttate, erythrodermic, pustular forms)

Psoriatic arthritis (lining up with GRAPPA/ACR priorities)

Immune pathways central to psoriatic disease:

IL-17 / IL-23 / Th17 axis

TNF pathways

JAK/STAT signaling

Skin barrier & keratinocyte biology

Itch, pain, fatigue, comorbidities (CV disease, metabolic syndrome, IBD, depression)

❗ Generic dermatology or immunology grants rarely succeed unless strongly tied to psoriasis/PsA pathogenesis or outcomes.

2. Perfect Fit With the NPF Funding Mechanism

Each mechanism has specific expectations:

Mechanism	Ideal Candidate	Key Emphasis
Discovery Grants	Early ideas	Novelty + feasibility
Translational Grants	Mid-career	Human relevance + clinical trajectory
Early Career Research Awards	New faculty	Mentorship + trajectory + preliminary data
Milestones to a Cure Awards	Established teams	High-impact, patient-centered advances
Health Outcomes Research Grants	Clinicians & population scientists	Real-world impact, QI, disparities
Psoriatic Arthritis Grants	Rheumatology focus	Patient involvement + biomarker/therapy relevance

Predictor: Matching career stage + aim + impact to the mechanism substantially increases scoring.

3. Innovation + Clear Impact on Patients

NPF loves fresh, bold ideas with visible clinical importance:

Novel targets or pathways

Treatment optimization & combination strategies

New biomarkers of response/remission

Digital health / remote monitoring

Understanding early PsA development (transition from skin → joint)

Tools reducing treatment burden or disparities

Predictor: Innovation that leads to better outcomes or quality of life is highly rewarded.

4. Relevant Human Data or Models

Even for Discovery grants, competitive proposals typically include:

PsO/PsA patient samples (blood, skin biopsies, synovial tissue)

Established mouse/complementary models (e.g., imiquimod-induced)

scRNA-seq or spatial data from psoriatic lesions

Real-world clinical cohorts

Predictor: Strong human relevance significantly increases feasibility and impact.

5. Preliminary Data That Supports Hypothesis & Feasibility

Not always required — but highly correlated with success.

Examples:

Cytokine expression differences in lesional samples

Pilot omics or bioinformatics signals

Early proof-of-concept treatment responses

Recruitment feasibility (for clinical studies)

Predictor: Preliminary data is a top differentiator for funding.

6. Alignment with NPF Priorities

High-priority areas include:

Treat-to-target in psoriasis/PsA

Disease prevention (esp. PsA prevention)

Health equity and access to biologics

Comorbidity burden reduction

Pediatric psoriasis

Early treatment to prevent joint damage

Quality of life improvements

Predictor: Strong alignment with strategic priorities improves scores.

7. Strong PI Trajectory, Especially for Early Career Awards

Reviewers consider:

First or co-first author publications in psoriatic disease or related fields

Clear independence from mentors

Long-term research vision in PsO/PsA

Evidence of productivity and grant-writing ability

Predictor: Demonstrated commitment to psoriatic disease science is key.

8. Effective Mentorship & Environment

Critical for early-stage mechanisms:

Mentor(s) with strong psoriasis/PsA expertise

Protected research time

Access to patient population & immunology cores

Institutional support letters with explicit commitments

Predictor: Strong environment = high confidence in success.

9. Patient-Centered Outcomes & Community Engagement

Especially valued in outcomes research:

Involving patients in study design or advisory roles

Real-world endpoints: fatigue, itch, QoL, flares, satisfaction

Cost-effectiveness & adherence strategies

Reducing disparities in treatment access

Predictor: Demonstrated patient benefit strengthens impact scoring.

10. Clear, Focused, Milestone-Driven Aims

Funded proposals are:

Well-scoped for a 1–2 year project

2–3 testable and hypothesis-driven aims

Include go/no-go checkpoints

Have contingency plans and measurable deliverables

Predictor: Clean structure and feasibility are essential to approval.

🏆 Summary Table — NPF Success Predictors

Predictor	Why It Matters
Psoriasis/PsA relevance	Core mission requirement
Mechanism alignment	Ensures appropriate expectations
Innovation with patient impact	Central scoring category
Human relevance	Boosts translational value
Preliminary data	Demonstrates feasibility
Strategic priority alignment	Improves competitiveness
Strong PI/mentorship	Increases reviewer confidence
Patient-centered design	Adds meaningful clinical impact
Focused Aims & milestones	Fits NPF timeline and scope
Strong writing & analysis plan	Boosts reviewer enthusiasm

Specialties

Dermatology

Eligibility Requirements

The principal investigator must be personally and actively responsible for the conduct of the proposed research, and eligible to apply for research grants under the guidelines of the applicant’s host institution. The project proposed must have been submitted as an unfunded application for either a K-type or R-type (or equivalent) award focused on psoriasis, psoriatic arthritis, or related comorbidities.

Sponsor Details

Sponsor Institute/Organizations: National Psoriasis Foundation

Sponsor Type: Corporate/Non-Profit

Address: 1800 Diagonal Rd., #360 Alexandria, VA 22314

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