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ISSCD-Beyond Celiac Translational Research Award

Beyond Celiac

The International Society of the Study of Celiac Disease (ISSCD) and Beyond Celiac are seeking applications for the ISSCD-Beyond Celiac Translational Research Award. The Award is a three-year grant of up to $100,000 USD annually, which includes up to 8% in indirect costs*.

The objective of the award is to encourage scientists to continue studying celiac disease or turn their focus on celiac disease if they work in a related field. Ultimately, the grant aims to secure a commitment and to keep celiac disease research on the long-term agenda of scientists.

The award is intended to support a translational research project, with the potential to advance disease knowledge and accelerate discovery and/or development of treatments for celiac disease. The funding period covers October 1, 2026, through September 30, 2029.

Phased Approach

The proposed project should be conducted using a three-phase approach in which the first phase, Phase 1, is intended for establishing the model and preliminary testing, for example: obtaining specimens, breeding animals, or establishing cell cultures.

The starts of Phase 2 and Phase 3 activities are contingent upon the completion of established milestones for Phase 1 and Phase 2, respectively.

Phase 1 activities will be conducted during Year 1 (months 1–12). Unless it can be accomplished more quickly or there is reason for delay, Phase 2 activities will be conducted during Year 2 (months 13–24), and Phase 3 activities will be conducted during Year 3 (months 25-36)

Submission Requirements

Candidates must submit a complete application through the ProposalCentral platform. In addition to the sections within the proposal, you must also upload the following documents in the Application Documents section:

Biosketch—use the template provided in the Download Templates & Instructions section
- The candidate’s NIH-style bio sketch must be provided and cannot exceed five (5) pages.
Research Plan—use the template provided in the Download Templates & Instructions section
Letter of Institutional Support—a letter, signed by the Department Chair or appropriate organizational official, confirming institutional support of the project.
Letter(s) of Collaboration (if applicable)—a signed letter from the collaborating individual(s) or organization(s) that demonstrates sufficient support and resources for the proposed project
Other Support—use the template provided in the Download Templates & Instructions section

Proposals will be completed within the ProposalCentral platform. Fill out each section as required.

To start your application, visit ProposalCentral, then click “Apply Now.”

Budget

A budget must be provided. You will enter your budget in the Budget Detail section of the application.

Funding requests may include:

Personnel (e.g., research assistant and/or faculty salary support; this should include a percentage of effort for the proposed study with appropriate justification)
Supplies and reagents
Expenses associated with research involving animals or human subjects
Travel expenses for conference presentations to present data during the grant period

Funding will not be provided for:

Travel after the completion of the grant period

Awards made in response to proposals involving research on vertebrate animals and/or human subjects will be contingent upon receipt of copies of approval letters from the requisite regulatory and ethics bodies.

Duration of funding

Three years. Unexpended funds must be returned to Beyond Celiac at the end of the research period.

Interim progress reports must be submitted to the ISSCD and Beyond Celiac after six months, one year, 18 months, two years, and 30 months of support, within 5 business days of each of these deadlines. A final progress report must be submitted to the ISSCD and Beyond Celiac within 30 days of conclusion of the project and a financial statement from the institutional grants or accounting office must be received for final payment.

All publications arising from this award must include the following statement “This research was supported by “ISSCD-Beyond Celiac Translational Research Award (ISSCD-global.org) (BeyondCeliac.org).”

Selection Criteria

The primary criteria for the Award include the scientific merit of the proposal and the investigator’s qualifications. Additional criteria include the environment of the host institution and the availability of resources judged essential for the success of the proposed research

Submission Deadline

The application deadline is 6:00 PM ET on July 1, 2026. The application and all supporting materials must be submitted electronically in the requested format on ProposalCentral.

Technical questions about the grant submission process can be addressed online by Proposal Central Customer Service (pcsupport@altum.com). Other questions can be directed to Kate Avery at kavery@beyondceliac.org and Info@isscd-global.org

Grant Award Announcement

The grant recipient will be announced in October 2026. Awardees will be notified via email.

*Indirect/Facilities and Administration costs: Defined as laboratory costs, utilities costs and compliance costs.

AI Based Application Success Predictor

🌾 1. Strong Focus on Celiac Disease (Non-Negotiable)

Projects must directly address:
- Celiac disease pathogenesis, diagnosis, or treatment
Includes:
- Gluten-triggered immune mechanisms
- Biomarkers
- Therapeutic development

👉 Non-celiac or loosely related GI research is rarely funded

🔬 2. High Scientific Innovation (Top Predictor)

Beyond Celiac prioritizes:
- Novel, breakthrough ideas
- High-risk / high-reward research
Especially:
- Projects that challenge current paradigms

👉 Incremental studies have low competitiveness

💊 3. Clear Path to Treatment or Cure (Critical)

A defining feature:

Strong emphasis on:
- Drug development or therapeutic strategies
Projects should:
- Move toward non-dietary treatments

👉 Key question:
“Will this help move us closer to a cure?”

🔄 4. Translational Focus (Bench → Patient)

Preference for:
- Research that can be applied clinically
- Biomarkers, diagnostics, or therapies

👉 Pure basic research must show clear translational trajectory

🧬 5. Mechanistic Understanding of Disease

Successful proposals often explore:

Immune response to gluten
Intestinal damage pathways
Genetic susceptibility (e.g., HLA-DQ2/DQ8)

👉 Mechanism-driven research strengthens proposals

⚡ 6. Urgency & Acceleration Potential

Beyond Celiac is mission-driven and patient-led
Projects must:
- Show potential for rapid progress
- Have clear milestones

👉 Speed toward impact is valued

👩‍🔬 7. Investigator Expertise & Commitment

Experience in:
- Gastroenterology
- Immunology
- Autoimmune diseases
Demonstrated commitment to celiac research

👉 Early-career applicants succeed with strong mentorship

🤝 8. Collaboration & Multidisciplinary Approach

Strong proposals often involve:
- Clinicians + immunologists + translational scientists
Collaboration with:
- Clinical centers or patient cohorts

🧪 9. Feasible Study Design

Clearly defined:
- Hypothesis
- Methods
- Timeline
Realistic within grant duration

👉 Overly ambitious proposals are frequently rejected

📊 10. Patient-Centered Impact

Emphasis on:
- Improving quality of life
- Reducing gluten burden
- Addressing unmet needs

👉 Patient benefit must be explicit and measurable

📊 Summary: Key Predictors (Ranked)

Highest impact factors:

Strong celiac disease focus
Innovation (high-risk/high-reward)
Clear path to treatment/cure

Moderate predictors:
4. Translational relevance
5. Mechanistic insight
6. Acceleration potential

Supporting factors:
7. Investigator expertise
8. Collaboration
9. Feasibility

💡 Insider Insight

Compared to other disease foundations:

Beyond Celiac is:
👉 highly mission-driven (toward a cure)
👉 innovation + speed focused

👉 Key evaluation question:
“Will this research meaningfully accelerate a cure or new treatment for celiac disease?”

Strong science ✔️
Clear therapeutic pathway ✔️
Patient impact ✔️
→ Highest success probability

Specialties

Clinical Trials

Others

Gastroenterology

Eligibility Requirements

Applicants must have a PhD or MD (or equivalent) and hold a full-time position at an academic institution. Individuals holding other research funding are eligible for this award. However, the proposed research should be an extension of our departure from the aims proposed in other awards. The research is to be conducted at an academic institution with all the appropriate facilities and policies in place to undertake the proposed research.

Sponsor Details

Sponsor Institute/Organizations: Beyond Celiac

Sponsor Type: Corporate/Non-Profit

Address: PO Box 544, Ambler, PA 19002

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