Annual Investigator Initiated Research (IIR) Grants: This program’s objective is to stimulate and fund studies that will clearly improve patient safety and lead to prevention of mortality and morbidity resulting from anesthesia mishaps. Potential areas of research include a wide variety of safety topics.
| Research Areas: | Clinical and educational research and development in anesthesia patient safety. See Areas of Research for more details. |
| Eligibility: | Awards are made to a sponsoring institution, not to individuals or departments. Any qualified member of a sponsoring institution (hospital, university, clinic, etc) in the United States or Canada may apply. |
| Amount: | Maximum award of $200,000, and with waiver up to $300,000. The maximum indirect cost rate is 15% of total direct costs and must be included in the total maximum award. |
| Duration: | Up to two years |
| Research Time: | The amount of time devoted to different projects is variable, but in most instances, 10-30% effort (research time) is appropriate. |
| Application Dates: | LOIs will be accepted electronically beginning: January 1, 2026 Letter of Intent due: February 15, 2026 at 5PM CST Full proposal (invitation only): August 15, 2026 |
The maximum award amount is $200,000, and with waiver* up to $300,000, for the entire term of the project. The maximum indirect cost rate is 15% of total direct costs and must be included in the total maximum award. The number of grants to be awarded will depend on the nature and quality of applications received and the total amount of funds available.
*To request a waiver, submit by email to the Administrator (grants@apsf.org) by Feb 5th (10 days before the due date). The request should contain a brief statement (up to 250 words) to justify for a waiver, such as conducting a multi-site clinical trial. Approval email must be included in the application if the requested budget is more than the maximum of $200,000.
Projects may be for up to 2 years in duration.
The amount of PI’s time devoted to the project is variable, but in most instances, 10-30% effort (research time) is appropriate.
APSF explicitly states that proposals are first evaluated for their potential contribution to anesthesia patient safety and prevention of morbidity and mortality. Applications lacking a clear connection to patient safety are commonly downgraded.
Successful projects typically address:
2. Clear Clinical Impact
Funded studies usually show how findings will:
Projects with a direct path from research findings to patient care implementation are specifically encouraged.
3. Rigorous Study Design
APSF identifies poor methodology and insufficient scientific rigor as common reasons for rejection.
Successful applications generally include:
4. Clear Hypothesis
According to APSF guidance, failure to present a clear hypothesis and rigorous research plan is among the most frequent reasons proposals receive low priority scores.
5. Near-Term Implementation Potential
A recurring characteristic of funded projects is a defined path toward implementation into clinical practice.
Examples from funded projects include:
6. Alignment with APSF Research Priorities
Projects aligned with APSF priorities tend to perform well, including:
7. Innovation
APSF strongly encourages innovative and creative approaches.
Recent funded examples include:
8. Multidisciplinary Teams
The Scientific Evaluation Committee frequently funds projects combining expertise from:
Cross-disciplinary teams are specifically encouraged.
9. Strong Mentorship for Early Investigators
For the APSF/FAER Mentored Research Training Grant, mentor quality and career-development environment are major considerations. APSF explicitly encourages junior investigators with strong mentorship structures.
10. Focus on Problems with Limited Alternative Funding
APSF notes that, because resources are limited, priority may be given to important patient-safety questions that are less likely to receive support from larger funding agencies.
Recent APSF-funded projects have focused on:
Funding Strategy
For APSF, the most competitive proposal usually demonstrates:
Awards are made to a sponsoring institution, not to individuals or departments. Any qualified member of a sponsoring institution (hospital, university, clinic, etc) in the United States or Canada may apply.
Eligible Countries:
Sponsor Institute/Organizations: Anesthesia Patient Safety Foundation
Sponsor Type: Corporate/Non-Profit
Address: P.O. Box 6668 Rochester, MN 55903
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Aug 15, 2026
Aug 15, 2026
$200,000
Affiliation: Anesthesia Patient Safety Foundation
Address: P.O. Box 6668 Rochester, MN 55903
Website URL: https://www.apsf.org/grants-and-awards/investigator-initiated-research-iir-grants/
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