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Imaging Research in Alzheimer’s and Other Neurodegenerative Diseases

Alzheimer's Association

Imaging is an important tool to better understand brain related changes in Alzheimer’s and other neurodegenerative diseases and to develop opportunities for early and accurate diagnosis. With ongoing and planned clinical studies to advance our understanding as well as to evaluate potential future treatments, it is important to incorporate imaging biomarkers into these trials as well as continuing to improve the diagnostic and prognostic power of these techniques.

The purpose of this partnership between the Alzheimer’s Association and the American Society of
Neuroradiology is to provide support for the advancement of the field of imaging of Alzheimer’s disease and other neurodegenerative diseases by providing support for early stage pilot projects that will advance research to support the development of new novel imaging tools, to advance imaging-based research and to provide funding for novel and innovative imaging data analysis.

This mechanism highly encourages investigators to include within an explicit plan for overcoming barriers to the enrollment of individuals from health disparity populations in their study.

The evaluation of causative factors including environmental and genetic factors contributing to disease development and progression, identifying potential new treatment strategies and information to improve care for people with dementia, and advancing our knowledge of risk reduction and disease prevention are long-term goals. The goal of this program is to translate research into strategies to increase our understanding of the pathogenesis of Alzheimer’s and other neurodegenerative diseases, and to help stratify populations and possible treatments.

Three awards, each having a maximum budget of $200,000 (including no more than 10% indirect costs), are available for one-year award.

Funding and award period

AASNR and the Alzheimer’s Association anticipates funding up to three proposals through this joint initiative. Each award is limited to $200,000 total funding (direct and indirect costs, indirect costs are restricted to no more than 10% including subcontracts) over a period of one year. Additional details on allowable costs are outlined in the budget section.

Key dates and deadlines:

Letter of Intent Launch: Sept. 19, 2025
Letter of Intent Deadline: Oct. 30, 2025
Letter of Intent Notification: Week of Dec. 16, 2025
Application Deadline: Jan. 28, 2026
Application Review: Jan. 26 - May 2026
Award Notifications: By May 15, 2026

The Letter of Intent and application must be received by 5 p.m. ET on their respective deadlines via ProposalCentral (instructions below). They will not be accepted after these dates – no exceptions will be made. Hard copies or emails will not be accepted.

AI Based Application Success Predictor

1️⃣ Clear Alzheimer’s- or Dementia-Focused Impact

Strongest proposals:

Directly address Alzheimer’s disease or related dementias (AD/ADRD)

Have clear potential for clinical relevance

Create new tools or mechanistic insight into disease processes

Target early detection, biomarkers, or disease modification

What weakens applications: peripheral neuroscience not clearly tied to AD/ADRD.

2️⃣ Innovation + High Scientific Merit

Reviewers value:

Novel concepts, new therapeutic or diagnostic approaches

Advances beyond incremental science

Unique data or methodologies that shift current paradigms

Follow the “So what?” rule — why does this matter for patients?

3️⃣ Strong Preliminary Evidence (Appropriate to Career Stage)

For AARG: Pilot data required to show feasibility

For early-career awards: data expectations are lower, but feasibility still must be credible

Clear hypotheses backed by prior work

Red flags: risk without rationale or missing feasibility.

4️⃣ Rigorous, Feasible Study Design

Robust statistical and methodological plans

Realistic timeline and budgets

Clearly defined milestones and deliverables

Alzheimer’s Association favors attainable outcomes within 2–3 years.

5️⃣ Early-Career / Diversification Focus (for Many Mechanisms)

Programs like AARG emphasize:

Rising investigators and those new to AD

Demonstrated commitment to an AD/ADRD career

Mentorship and appropriate training environment

Explicitly articulate career development goals.

6️⃣ Diversity, Equity, Inclusion + Underrepresented Populations

Major priority in current cycles:

Research addressing health disparities

Recruitment strategies for diverse populations

Investigators from underrepresented groups

Global and community-engaged research encouraged

DEI sections are scored, not optional.

7️⃣ Team Strength + Environment

Reviewers assess whether:

The institution can support completion of the proposed work

Team roles are clear and experienced

Core resources (e.g. imaging, analytics) are available

For early-career grants: strong mentoring plans matter.

8️⃣ Clear Path to Next-Phase Funding

Highly valued:

Plans to obtain future NIH/major funding

Preliminary aims designed to enable R01-level proposals

Translational or scalable trajectory

Review panels ask:
“Will this investment unlock larger progress?”

9️⃣ Well-Written, Persuasive Narrative

Concise rationale, strong significance

Clear linkage from aims → methods → outcomes → impact

Professional presentation (no sloppiness!)

Applications are competitive — solid storytelling matters.

🚫 Common Pitfalls

Weak Aspect	Reviewer Concern
Alzheimer’s connection is weak	“Not relevant enough”
Too ambitious for timeline	“Unlikely to complete”
No future funding plan	“Low return on investment”
Lack of diversity plan	Modern cycles require DEI strength
Poor writing/figures	“Unclear significance or feasibility”

🎯 Success Strategy: What to Emphasize

✔ AD-focused impact
✔ Innovation + rationale + pilot proof
✔ Feasibility and achievable milestones
✔ Strong mentoring/training (if early career)
✔ DEI plan with measurable actions
✔ Path to future NIH/large funding

Specialties

Cancer

Neurosciences

Eligibility Requirements

Awards made through this joining initiative support investigators at every professional stage and are also designed to help talented scientists establish careers in Alzheimer’s and other neurodegenerative imaging research.
Submissions from collaborative research that have experience across aging and neurodegenerative diseases are strongly encouraged. Novel and creative ideas are sought, and proposals should also demonstrate feasibility.
Neuroradiologists (MD, MD/PhD, DO) and scientists (PhD) with faculty appointments in radiology departments are encouraged to apply, including instructor, assistant, associate, and full professor levels.
Training or mentoring-only proposals will not be considered.
Multidisciplinary teams are encourage to apply.

Note: Alzheimer’s Association grants are generally open to scientists and researchers across the globe; however, as a U.S.-based charity, the Alzheimer’s Association is subject to, and complies with, U.S. law. As a result, the Alzheimer’s Association cannot award, and will not award, grants in violation of applicable U.S. statutes and regulations. This means, among other things, that the Alzheimer’s Association cannot, and will not, fund any individual or entity (i) that is subject to U.S. comprehensive or targeted sanctions or if awarding funding would result in a violation of such sanctions, (ii) that is on the U.S. List of Specially Designated Nationals or entities owned or controlled by such persons, or (iii) when doing so is otherwise prohibited by U.S. laws related to combating terrorism.

Sponsor Details

Sponsor Institute/Organizations: Alzheimer's Association

Sponsor Type: Corporate/Non-Profit

Address: 225 N Michigan Ave. Floor 17 Chicago, IL 60601 800.272.3900

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