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HESI THRIVE Grants

Health and Environmental Sciences Institute (HESI)

PURPOSE

The THRIVE grant program is designed to provide seed funding to investigators for the testing of initial hypotheses and collecting of preliminary data to help secure long-term funding by the National Institutes of Health and/or other major granting institutions.

FUNDING

Funding awards are $50,000 USD per awardee for up to 24 months of direct costs.

Submissions must include a proposed timeline for initiation and completion of the experimental work. All experimental work is to be completed within a maximum of 24 months.
Awardees will be required to provide a written study update at the 12 month mark and at completion of the study.
Upon receipt of a signed notification and agreement to THRIVE award terms (including IRB or IACUC approval) THRIVE will disburse 75% of the funds. The remaining 25% of the award is provided upon completion of the study milestones. Exceptions may be made.
If funding permits, awardees may also receive additional travel funds to support their participation in the HESI THRIVE annual research meeting and networking event.

APPLICATION PROCESS

All letters of intent and grant applications are to be submitted through the ProposalCentral website at https://proposalcentral.com/.

AI Based Application Success Predictor

HESI does not operate like traditional grant agencies; success is based on collaborative project participation and proposal alignment:

🥇 1. Strong Alignment with Risk Assessment & Safety Science (Top Predictor)

Must relate to:
- Toxicology
- Environmental health
- Chemical safety

✔ Core focus: human health risk assessment

🥈 2. Multisector Collaboration (Critical)

One of the strongest predictors

✔ Successful projects involve:

Academia + industry + regulators

🥉 3. Regulatory Relevance

Preference for:
- Research influencing policy or guidelines

✔ High success:

Projects with regulatory application

4. Translational & Applied Science

Focus on:
- Real-world applicability

✔ Not purely basic research

5. Methodological Innovation

Competitive proposals include:
- New testing approaches
- Alternative methods (non-animal models)
- Advanced analytics

6. Consensus-Building Potential

Unique to HESI:
- Ability to generate scientific consensus

✔ Projects that unify stakeholders score higher

7. Feasibility & Practical Impact

Must demonstrate:
- Clear outcomes
- Applicability

8. Global Health & Environmental Impact

Preference for:
- Broad, scalable impact

🧪 Common Research Areas

Toxicology and safety assessment
Environmental exposure science
Biomarkers of toxicity
Alternative testing methods
Risk assessment frameworks
Chemical safety and regulation

⚠️ Common Reasons for Rejection

Lack of regulatory relevance
No collaboration across sectors
Purely academic/basic research
Limited real-world application

🧠 Bottom Line (Key Predictors Ranked)

Alignment with risk assessment/toxicology
Multisector collaboration (critical)
Regulatory relevance
Applied/translational science
Consensus-building potential
Feasible, impactful outcomes

Specialties

Environmental Health

Eligibility Requirements

Principal investigator(s) must hold an M.D., Ph.D., D.V.M., or equivalent degree. Candidates for these degrees along with their Principal Investigator may apply. All candidates must have an accredited faculty, medical institution, or other research institute appointment and have the ability to conduct independent research with publications in established peer-reviewed medical and scientific journals. This funding opportunity is open internationally. Awardees must be willing to participate in the annual HESI THRIVE research forum – an opportunity to share results and build a network of experts.

Sponsor Details

Sponsor Institute/Organizations: Health and Environmental Sciences Institute (HESI)

Sponsor Type: Corporate/Non-Profit

Address: 740 15th Street NW, Suite 600 Washington, DC 20005

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