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Endeavour Project Grant

Epilepsy Research Institute UK

Scope

Applications are invited for awards of up to £175,000, for up to three years.

Endeavour Project Grant awards provide research funding for fundamental, data, and clinical projects investigating the causes, diagnosis, or treatment of epilepsy and associated conditions. Project grant proposals should investigate a hypothesis that has been based on pilot data, with the aim of substantially contributing to furthering knowledg

Applications permitted per grant round

During any Epilepsy Research Institute grant round, an applicant can submit one application per award type (e.g., Endeavour Project Grant). For Fellowships, an individual researcher may be named as a supervisor on a maximum of two applications.

There is no limit on the number of times an individual researcher can be named as a co-applicant on submitted applications. However, co-applicants’ roles should be clearly defined within the application.

Active awards permitted

At any time, an individual researcher may be named as the principal investigator or supervisor on a maximum of two active grants. This includes Endeavour Project Grants, Explore Pilot Grants, all Fellowships, and co-funded PhD studentships. Being a PhD supervisor within our Doctoral Training Centres does not count towards this limit.

Please note that existing Epilepsy Research Institute grant holders are not eligible for funding unless the reporting of outcomes from their existing funded grants is up to date.

AI Based Application Success Predictor

1️⃣ Clear Relevance to Transforming Outcomes in Epilepsy (Most Important)

Proposals must demonstrate:

Direct relevance to epilepsy mechanisms, diagnosis, treatment, or care

Benefit to people living with epilepsy in the near-to-medium term

Contribution to high-burden, high-need areas (drug-resistant epilepsy, SUDEP, comorbidities)

Predictor: Strong epilepsy-specific focus and patient benefit.

2️⃣ Strong Innovation with Realistic Feasibility

ERI UK supports innovative, bold ideas, but only when backed by rigor.

High-scoring applications show:

Conceptual novelty

New technologies, biomarkers, or therapeutic strategies

Innovative data science or systems approaches

Use of cutting-edge models (iPSC, organoids, chronic recordings, computational models)

Predictor: Innovation must be paired with a feasible plan.

3️⃣ High-Quality, Rigorous Methodology

Reviewers expect:

Robust experimental design

Appropriate controls, sample sizes, statistics

Clear milestones and timelines

Risk mitigation strategies

Use of validated models of epilepsy (in vitro, in vivo, human data)

Predictor: Methodological excellence is essential.

4️⃣ Strong Translational Pathway

One of ERI UK's strongest criteria.

Winning proposals demonstrate:

A credible path from discovery to improved diagnosis, treatment, or monitoring

Potential clinical application within a reasonable timeframe

Partnerships between basic scientists and clinicians

Early evidence of target engagement, biomarker potential, or device feasibility

Predictor: Clear clinical relevance and translational momentum.

5️⃣ Meaningful Patient & Public Involvement (PPI)

A major differentiator in UK-based health funding.

Competitive applications:

Demonstrate co-production with people living with epilepsy

Involve patients in shaping research questions, outcomes, dissemination

Describe PPI activities clearly and authentically

Predictor: Strong PPI is often a deciding factor between similar proposals.

6️⃣ Strong Team Expertise & Interdisciplinary Collaboration

Successful proposals involve teams with:

Complementary expertise (neurology, genetics, engineering, psychiatry, imaging, statistics)

Track record in epilepsy research

Feasible access to patient cohorts, biobanks, EEG/MEG/SEEG, imaging infrastructure

Engagement with UK epilepsy research networks

Predictor: Credible, collaborative teams score highest.

7️⃣ Focus on Areas of Strategic Priority

ERI UK explicitly prioritizes:

✔ Drug-resistant epilepsy

✔ SUDEP mechanisms & prevention

✔ Precision medicine (genetic epilepsies, targeted therapies)

✔ Big data, artificial intelligence, digital biomarkers

✔ Epilepsy in children and vulnerable groups

✔ Neuroinflammation and epileptogenesis

✔ Mental health, cognition, and quality-of-life research

Predictor: Alignment with these priorities strengthens competitiveness.

8️⃣ Access to Data, Patients, Models, or Clinical Partners

Reviewers examine feasibility through:

Confirmed access to patient datasets or clinical populations

Letters of support from NHS trusts or epilepsy centers

Availability of experimental models and infrastructure

Ethical and governance readiness

Predictor: Feasibility enhances confidence in deliverability.

9️⃣ Clear Plan for Pathway to Future Funding (NIHR, MRC, Wellcome)

ERI UK wants to invest in research that can grow.

High-performing proposals:

Clearly describe how ERI funding will generate preliminary data

Outline next steps for national funding leverage (MRC Development Pathway, NIHR HTA, Wellcome Discovery)

Predictor: Strong scalability plan.

🔟 Strong, Justified Budget

Budgets must be:

Realistic

Proportional to the aims

Well explained

Efficient, especially in pilot awards

Predictor: Lean, transparent budgeting → stronger proposal.

🚫 COMMON PITFALLS (Reasons ERI UK Applications Are Not Funded)

Pitfall	Why It Fails
Weak link to epilepsy	Immediate disqualification
Overly ambitious scope	Feasibility concerns
Poor statistical planning	Lack of rigor
No patient involvement	Major weakness
Insufficient clinical relevance	Low impact
Weak preliminary data	High-risk without justification
No clear translational pathway	Not aligned with ERI strategy
Lack of interdisciplinarity	Reduces chances of success

Specialties

Neurosciences

Eligibility Requirements

Applicants should be graduates in medicine, one of the sciences allied to medicine, neuroscience, engineering, or mathematics. We advise applicants who are external to the epilepsy field to include a senior expert in epilepsy as a supervisor or collaborator on their proposal. Applicants must be a resident in the UK and affiliated with an academic institution in the UK.

Sponsor Details

Sponsor Institute/Organizations: Epilepsy Research Institute UK

Sponsor Type: Corporate/Non-Profit

Address: Churchill House 35 Red Lion Square London WC1R 4SG

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