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Drug Discovery Predoctoral Fellowship

PhRMA Foundation

Drug discovery involves the innovative application and integration of multiple scientific disciplines to create efficacious, safe, and differentiated treatment options for patients. The PhRMA Foundation seeks to fund novel, early-stage, drug discovery research with a clear potential for translation to humans.

Scope of Research

Research areas could include, but are not limited to:

Target identification and validation using genetic engineering (e.g., CRISPR-Cas9) and phenotypic screens (e.g., 3-D cell culture)
Mapping disease mechanisms using single-cell and spatial multi-omics approaches to identify disease-relevant targets (e.g., scRNA-seq, spatial transcriptomics, spatial proteomics)
Hit and lead identification with validation and molecular modeling (including structure-enabled discovery of novel drug modalities)
Protein biochemistry and structural biology, including computational approaches
Cellular and molecular biology approaches to elucidate therapeutically relevant pathways and mechanisms
In vitro (cell-based) and in vivo (animal) studies that assess drug candidate pharmacological profiles (e.g., mechanism of action, effectiveness, safety and toxicity)
Applications of advanced biomedical imaging in vitro (e.g., cellular high-content screening for target identification and validation) and in vivo (e.g., PET, MRI/CT for drug target engagement and biodistribution)
Artificial intelligence (AI) and computational approaches that directly advance a therapeutic hypothesis

Specialties

Drug Development

Pharmaceuticals

Eligibility Requirements

Applicants (U.S. and non-U.S. citizens) must attend an accredited U.S. university as full-time, in-residence students.
Individuals just beginning graduate school should not apply. Applicants must have completed most of their pre-thesis requirements (at least two years of coursework) and be engaged in thesis research as PhD candidates by the time the award is activated. Award activation can begin as early as January 1, 2027, or as late as August 1, 2027.
Applicants who expect to complete their PhD before December 1, 2027, are ineligible.
Applicants enrolled in MD/PhD programs should not be engaged in required clinical coursework or clerkships while the fellowship is active. Fellows are expected to devote full time (including summers) to their research.
Applicants who have not authored a publication or presented a poster are ineligible.
Applicants currently funded on an institutional training grant (e.g., NIH TL1, T32, T90, or T35 awards or a nonprofit/professional society equivalent) may apply if they state they will forgo the institutional training slot if funded by a PhRMA Foundation predoctoral award.
Applicants are ineligible if they are the recipient of an NIH-F award.
An individual may not simultaneously hold another funding mechanism providing stipend support while the PhRMA Foundation predoctoral fellowship is active. If necessary, the university may supplement the Foundation’s award to a level that is consistent with other predoctoral fellowships it offers.
The predoctoral fellowship is not intended to fund work already supported by a principal investigator’s active grants.
Only one applicant per lab may apply in the Drug Discovery Program. Labs must select either a predoc, a postdoc, or a faculty member.

Sponsor Details

Sponsor Institute/Organizations: PhRMA Foundation

Sponsor Type: Corporate/Non-Profit

Address: 670 Maine Avenue SW, Suite 1000 Washington DC

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