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Maximizing Investigators' Research Award (MIRA) (R35 - Clinical Trial Optional)

National Institutes of Health

The Maximizing Investigators' Research Award (MIRA) provides support for individual investigators for research within the scientific mission of NIGMS via a single grant to achieve the following:

Increase the stability of funding for NIGMS-supported investigators, which could enhance their ability to take on ambitious scientific projects and approach problems more creatively;
Increase flexibility for investigators to follow important new research directions within the NIGMS mission as opportunities arise, rather than being bound to specific aims proposed in advance of the studies;
More widely distribute funding among the nation's highly talented and promising investigators to increase overall scientific productivity and the chances for important breakthroughs;
Reduce the time spent by researchers writing and reviewing grant applications, allowing them to spend more time conducting research;
Reduce the administrative burden associated with a PD/PI managing multiple NIGMS research grants; and
Enable PD(s)/PI(s) to devote more time and energy to mentoring junior scientists in a more stable research environment.

This NOFO invites applications from eligible NIGMS-funded investigators and from New Investigators proposing research that is aligned with NIGMS' scientific mission. The NOFO also allows renewal applications from all current MIRA grantees (including those previously funded as Early-Stage Investigators). Current Early-Stage Investigators (ESIs) should apply through the ESI MIRA NOFO, not this NOFO.

Application Due Date(s): Jan 27, 2026; May 27, 2026; Jan 27, 2027; May 27, 2027; Jan 27, 2028; May 26, 2028

PAR-26-121 Expiration Date May 27, 2028

Specialties

Medical

Medical - Clinical Science

Medical - Basic Science

Medical - Translational

Eligibility Requirements

PDs/PIs whose only NIGMS research grant(s) is a multi-PD/PI grant(s) are not eligible to apply for a MIRA.

PDs/PIs with a funded NIGMS MIRA are eligible to submit a MIRA renewal application before the end of their eligibility time window. Successful renewal applications will generally be awarded in the fiscal year of Council review, with the current MIRA terminated upon the issuance of the MIRA renewal award. Resubmissions are not allowed. If a renewal MIRA application is unsuccessful, a new MIRA application may be submitted as long as the PD/PI remains eligible. The eligibility for investigators funded with a MIRA extends to the end of the second fiscal year following the one in which the funded MIRA was originally set to expire. For example, if the current MIRA expires in fiscal year 2025 (October 1, 2024 to September 30, 2025), a renewal MIRA application needs to be submitted before September 30, 2027.

PDs/PIs with at least one NIGMS single-PD/PI R01-equivalent award (defined here as R01, R37, DP1, DP2, and SC1) are eligible to submit a new MIRA application before the end of their eligibility time window. Successful MIRA applications will generally be awarded in the fiscal year of Council review. If a pending MIRA application is unsuccessful, a new MIRA application may be submitted as long as the PD/PI remains eligible. Resubmissions are not allowed. The eligibility for investigators funded with at least one single-PD/PI NIGMS R01 or equivalent award extends to the end of the fiscal year following the one in which the funded single-PD/PI R01 or equivalent award was originally set to expire. For example, if the qualifying R01-equivalent award ends in fiscal year 2025 (October 1, 2024 to September 30, 2025), a MIRA application needs to be submitted before September 30, 2026.

No-cost extensions (NCEs) cannot be used to extend the eligibility time window. NIGMS will consider requests to extend the eligibility time window to apply for a MIRA for life events (e.g., childbirth or adoption, military service, health-related issues, natural disasters) that impact research progress during the eligibility time window, as well as unanticipated administrative issues. Applicants seeking an extension of their eligibility status must contact a Scientific/Research Contact listed in this NOFO (in Section VII. Agency Contacts ) at least 8 weeks before submitting the application.

New Investigators proposing NIGMS mission- aligned research programs are eligible to apply for a MIRA if the PD/PI is not a project leader on any NIH multi- component awards from NIH, except for Research Project Leaders and Pilot Project Leaders of COBRE, IDeA-CTR or NARCH awards. Potential applicants are strongly encouraged to contact NIGMS program staff to discuss the possible alignment of their proposed research program to the NIGMS mission before applying. Applications that fall outside the NIGMS scientific mission will be withdrawn prior to peer review.

ESIs should apply for a MIRA through the ESI MIRA NOFO, not this NOFO.

The PD/PI is required to devote at least 45% of their total research effort to the MIRA. Total research effort includes the PD's/PI's combined research effort across all institutions where they hold an appointment, expressed in person-months, and excludes time spent on teaching and on administration unrelated to the PD's/PI's research or clinical duties. NIGMS staff will verify compliance with the MIRA research effort requirement using the Just-in-Time (JIT) Other Support documentation.

Sponsor Details

Sponsor Institute/Organizations: National Institutes of Health

Sponsor Type: Government/Federal

Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA

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